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Metastatic Malignant Peripheral Nerve Sheath Tumor

MedGen UID:
233182
•Concept ID:
C1334720
•
Neoplastic Process
Synonym: Metastatic MPNST

Definition

The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Peripheral Nerve Sheath Tumor

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Treatment of malignant peripheral nerve sheath tumors in pediatric NF1 disease.
Martin E, Flucke UE, Coert JH, van Noesel MM
Childs Nerv Syst 2020 Oct;36(10):2453-2462. Epub 2020 Jun 3 doi: 10.1007/s00381-020-04687-3. PMID: 32494969Free PMC Article

Recent clinical studies

Etiology

Clinical and Neuroimaging Features of Magnetic Resonance-Guided Stereotactic Laser Ablation for Newly Diagnosed and Recurrent Pediatric Brain Tumors: A Single Institutional Series.
Pehlivan KC, Khanna PC, Elster JD, Paul MR, Levy ML, Crawford JR, Gonda DD
World Neurosurg 2021 Jun;150:e378-e387. Epub 2021 Mar 17 doi: 10.1016/j.wneu.2021.03.027. PMID: 33722713

Diagnosis

Metastatic malignant peripheral nerve sheath tumor. A diagnostic surprise.
Bai M, Govindaraj V, Chauhan AS, Srinivas BH, Sree Rekha J, Narenchandra V
Monaldi Arch Chest Dis 2021 May 6;91(2) doi: 10.4081/monaldi.2021.1658. PMID: 34256542
Metastatic Malignant Peripheral Nerve Sheath Tumor.
Soares do Brito J, Almeida P, Portela J
Acta Med Port 2016 Apr;29(4):290. Epub 2016 Apr 29 doi: 10.20344/amp.6912. PMID: 27349784
Metastatic malignant peripheral nerve sheath tumor in neurofibromatosis type 1: a geriatric patient report.
Firat C, Aytekin AH, Erbatur S
Eur Rev Med Pharmacol Sci 2012 Sep;16(9):1301-4. PMID: 23047517
Metastatic malignant peripheral nerve sheath tumor of the cauda equina.
Than KD, Ghori AK, Wang AC, Pandey AS
J Clin Neurosci 2011 Jun;18(6):844-6. Epub 2011 Mar 29 doi: 10.1016/j.jocn.2010.08.039. PMID: 21450470
Metastatic malignant peripheral nerve sheath tumor in a newborn.
Lisowski LA, Bramer JA, de Jonge MC, Bras J, Van der Horst CM, de Kraker J
J Pediatr Hematol Oncol 2008 Dec;30(12):891-5. doi: 10.1097/MPH.0b013e31818b3572. PMID: 19131773

Therapy

Clinical and Neuroimaging Features of Magnetic Resonance-Guided Stereotactic Laser Ablation for Newly Diagnosed and Recurrent Pediatric Brain Tumors: A Single Institutional Series.
Pehlivan KC, Khanna PC, Elster JD, Paul MR, Levy ML, Crawford JR, Gonda DD
World Neurosurg 2021 Jun;150:e378-e387. Epub 2021 Mar 17 doi: 10.1016/j.wneu.2021.03.027. PMID: 33722713
Metastatic Malignant Peripheral Nerve Sheath Tumor With NF1 Successfully Treated With 'Gradual Subtraction' ICE Chemotherapy.
Wang Y, Katagiri H, Murata H, Wasa J, Miyagi M, Kakuda Y, Takahashi M
Anticancer Res 2020 Mar;40(3):1619-1624. doi: 10.21873/anticanres.14110. PMID: 32132065

Prognosis

Metastatic Malignant Peripheral Nerve Sheath Tumor With NF1 Successfully Treated With 'Gradual Subtraction' ICE Chemotherapy.
Wang Y, Katagiri H, Murata H, Wasa J, Miyagi M, Kakuda Y, Takahashi M
Anticancer Res 2020 Mar;40(3):1619-1624. doi: 10.21873/anticanres.14110. PMID: 32132065
Metastatic malignant peripheral nerve sheath tumor in a newborn.
Lisowski LA, Bramer JA, de Jonge MC, Bras J, Van der Horst CM, de Kraker J
J Pediatr Hematol Oncol 2008 Dec;30(12):891-5. doi: 10.1097/MPH.0b013e31818b3572. PMID: 19131773

Supplemental Content

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