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Metastatic Breast Signet Ring Cell Carcinoma

MedGen UID:
233187
•Concept ID:
C1334740
•
Neoplastic Process
Synonyms: Metastatic Breast Signet-Ring Cell Carcinoma; Metastatic Mammary Signet Ring Cell Carcinoma; Metastatic Signet Ring Cell Breast Carcinoma; Metastatic Signet Ring Cell Carcinoma of Breast; Metastatic Signet Ring Cell Carcinoma of the Breast; Metastatic SRC Breast Carcinoma; Metastatic SRC Carcinoma of Breast; Metastatic SRC Carcinoma of the Breast

Definition

A signet ring cell carcinoma that arises from the breast and has metastasized to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Breast Signet Ring Cell Carcinoma

Professional guidelines

PubMed

Signet-ring cell sinus histiocytosis: report of the clinicopathologic characteristics of 4 cases with emphasis on the differential diagnosis of signet-ring cell lesions.
Argyris PP, Koutlas IG, Wakely PE Jr
Hum Pathol 2023 Sep;139:47-54. Epub 2023 Jul 15 doi: 10.1016/j.humpath.2023.07.006. PMID: 37459900
Surgical treatment for patients with different origins of Krukenberg tumors: outcomes and prognostic factors.
Jiang R, Tang J, Cheng X, Zang RY
Eur J Surg Oncol 2009 Jan;35(1):92-7. Epub 2008 Jul 16 doi: 10.1016/j.ejso.2008.05.006. PMID: 18632244

Recent clinical studies

Etiology

Cytological and molecular characterization of secretory breast carcinoma.
Carretero-Barrio I, Santón A, Caniego Casas T, López Miranda E, Reguero-Callejas ME, Pérez-Mies B, Benito A, Palacios J
Diagn Cytopathol 2022 Jul;50(7):E174-E180. Epub 2022 Feb 14 doi: 10.1002/dc.24945. PMID: 35156343Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
SATB2 Is Superior to CDX2 in Distinguishing Signet Ring Cell Carcinoma of the Upper Gastrointestinal Tract and Lower Gastrointestinal Tract.
Ma C, Lowenthal BM, Pai RK
Am J Surg Pathol 2018 Dec;42(12):1715-1722. doi: 10.1097/PAS.0000000000001159. PMID: 30212392
Signet ring cell carcinoma of the eccrine sweat glands in the eyelid.
Wollensak G, Witschel H, Böhm N
Ophthalmology 1996 Nov;103(11):1788-93. doi: 10.1016/s0161-6420(96)30426-0. PMID: 8942871
Signet ring carcinoma of the female breast: a clinicopathologic analysis of 24 cases.
Merino MJ, Livolsi VA
Cancer 1981 Oct 15;48(8):1830-7. doi: 10.1002/1097-0142(19811015)48:8<1830::aid-cncr2820480821>3.0.co;2-h. PMID: 6269726

Diagnosis

Cytological and molecular characterization of secretory breast carcinoma.
Carretero-Barrio I, Santón A, Caniego Casas T, López Miranda E, Reguero-Callejas ME, Pérez-Mies B, Benito A, Palacios J
Diagn Cytopathol 2022 Jul;50(7):E174-E180. Epub 2022 Feb 14 doi: 10.1002/dc.24945. PMID: 35156343Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.
Turashvili G, Samore WR, Oliva E, Ioffe O, Riddell R, Park KJ, Horn LC
Am J Surg Pathol 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. PMID: 32910021Free PMC Article
Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He CL, Chen P, Xia BL, Xiao Q, Cai FL
World J Surg Oncol 2015 Mar 26;13:120. doi: 10.1186/s12957-015-0538-1. PMID: 25890325Free PMC Article

Therapy

Therapeutic plasma exchange in gastric signet ring cell carcinoma presenting as microangiopathic hemolytic anemia: A rare case report.
Candar O, Ekinci O, Merter M, Aslan M, Aras I
J Clin Apher 2022 Dec;37(6):606-610. Epub 2022 Sep 20 doi: 10.1002/jca.22013. PMID: 36125111
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He CL, Chen P, Xia BL, Xiao Q, Cai FL
World J Surg Oncol 2015 Mar 26;13:120. doi: 10.1186/s12957-015-0538-1. PMID: 25890325Free PMC Article
Metastatic signet-ring cell carcinoma of unknown primary origin.
Gregoire C, Muller G, Machiels JP, Goeminne JC
Acta Clin Belg 2014 Apr;69(2):135-8. doi: 10.1179/0001551213Z.0000000002. PMID: 24724758
Signet-ring cell carcinoma of the breast with uterine metastasis treated with extensive cytoreductive surgery: a case report and brief review of the literature.
Ertas IE, Sayhan S, Karagoz G, Yildirim Y
J Obstet Gynaecol Res 2012 Jun;38(6):948-52. Epub 2012 Apr 9 doi: 10.1111/j.1447-0756.2011.01807.x. PMID: 22486859

Prognosis

Lobular Carcinoma of the Breast Metastatic to the Ovary: A Clinicopathologic Study of 38 Cases.
Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.
Turashvili G, Samore WR, Oliva E, Ioffe O, Riddell R, Park KJ, Horn LC
Am J Surg Pathol 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. PMID: 32910021Free PMC Article
Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He CL, Chen P, Xia BL, Xiao Q, Cai FL
World J Surg Oncol 2015 Mar 26;13:120. doi: 10.1186/s12957-015-0538-1. PMID: 25890325Free PMC Article

Clinical prediction guides

Cytological and molecular characterization of secretory breast carcinoma.
Carretero-Barrio I, Santón A, Caniego Casas T, López Miranda E, Reguero-Callejas ME, Pérez-Mies B, Benito A, Palacios J
Diagn Cytopathol 2022 Jul;50(7):E174-E180. Epub 2022 Feb 14 doi: 10.1002/dc.24945. PMID: 35156343Free PMC Article
Lobular Carcinoma of the Breast Metastatic to the Ovary: A Clinicopathologic Study of 38 Cases.
Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.
Turashvili G, Samore WR, Oliva E, Ioffe O, Riddell R, Park KJ, Horn LC
Am J Surg Pathol 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. PMID: 32910021Free PMC Article
Differentiating breast carcinoma with signet ring features from gastrointestinal signet ring carcinoma: assessment of immunohistochemical markers.
Hui Y, Wang Y, Nam G, Fanion J, Sturtevant A, Lombardo KA, Resnick MB
Hum Pathol 2018 Jul;77:11-19. Epub 2018 Jan 6 doi: 10.1016/j.humpath.2018.01.002. PMID: 29317235Free PMC Article

Recent systematic reviews

Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524

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