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Middle ear carcinoma

MedGen UID:
233189
•Concept ID:
C1334760
•
Neoplastic Process
Synonyms: Carcinoma of Middle Ear; carcinoma of middle Ear; carcinoma of middle ear; Carcinoma of the Middle Ear; carcinoma of the middle ear; carcinoma of the middle Ear; Middle Ear Carcinoma; middle ear carcinoma; middle Ear carcinoma
 
Monarch Initiative: MONDO:0003190

Definition

A carcinoma that arises from the middle ear. This category includes adenocarcinoma and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle ear carcinoma

Professional guidelines

PubMed

A Comprehensive Study on the Diagnosis and Management of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
Alzumaili BA, Krumeich LN, Collins R, Kravchenko T, Ababneh EI, Fisch AS, Faquin WC, Nosé V, Martinez-Lage M, Randolph GW, Gartland RM, Lubitz CC, Sadow PM
Thyroid 2023 May;33(5):566-577. Epub 2023 Mar 30 doi: 10.1089/thy.2023.0035. PMID: 36960710Free PMC Article
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome.
Coca-Pelaz A, Takes RP, Hutcheson K, Saba NF, Haigentz M Jr, Bradford CR, de Bree R, Strojan P, Lund VJ, Mendenhall WM, Nixon IJ, Quer M, Rinaldo A, Ferlito A
Adv Ther 2018 Feb;35(2):153-160. Epub 2018 Feb 2 doi: 10.1007/s12325-018-0663-7. PMID: 29396681

Recent clinical studies

Etiology

Temporal bone management in external and middle ear carcinoma.
Gowrishankar S, Borsetto D, Marinelli J, Panizza B
Curr Opin Otolaryngol Head Neck Surg 2024 Apr 1;32(2):138-142. Epub 2024 Jan 8 doi: 10.1097/MOO.0000000000000959. PMID: 38193562
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma.
Zhang F, Sha Y
J Laryngol Otol 2013 Jun;127(6):578-83. Epub 2013 May 2 doi: 10.1017/S0022215113000923. PMID: 23635547
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma.
Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L
ORL J Otorhinolaryngol Relat Spec 2012;74(1):16-21. Epub 2011 Dec 16 doi: 10.1159/000334243. PMID: 22178867
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882

Diagnosis

Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: an effective treatment modality case report.
Fong PY, Tan TY, Kiong KL
J Otolaryngol Head Neck Surg 2021 Jan 6;50(1):1. doi: 10.1186/s40463-020-00489-4. PMID: 33407879Free PMC Article
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma.
Zhang F, Sha Y
J Laryngol Otol 2013 Jun;127(6):578-83. Epub 2013 May 2 doi: 10.1017/S0022215113000923. PMID: 23635547
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882
Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report.
Takahashi K, Yamamoto Y, Sato K, Sato Y, Takahashi S
Otol Neurotol 2005 Jan;26(1):105-8. doi: 10.1097/00129492-200501000-00019. PMID: 15699729

Therapy

Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: an effective treatment modality case report.
Fong PY, Tan TY, Kiong KL
J Otolaryngol Head Neck Surg 2021 Jan 6;50(1):1. doi: 10.1186/s40463-020-00489-4. PMID: 33407879Free PMC Article

Prognosis

Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma.
Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L
ORL J Otorhinolaryngol Relat Spec 2012;74(1):16-21. Epub 2011 Dec 16 doi: 10.1159/000334243. PMID: 22178867
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882
Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report.
Takahashi K, Yamamoto Y, Sato K, Sato Y, Takahashi S
Otol Neurotol 2005 Jan;26(1):105-8. doi: 10.1097/00129492-200501000-00019. PMID: 15699729
Middle ear carcinoma.
Kulczyńskl B, Skonieczny J
Pol Tyg Lek 1976 Aug 2;31(31):1333-5. PMID: 967743

Clinical prediction guides

Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882

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