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Non-Neoplastic Breast Disorder

MedGen UID:
233231
•Concept ID:
C1334998
•
Disease or Syndrome
Synonyms: Non-Neoplastic Breast Disease; Non-Neoplastic Disease of Breast; Non-Neoplastic Disease of the Breast

Definition

A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis. [from NCI]

Professional guidelines

PubMed

Evaluation of scoring system in cytological diagnosis and management of breast lesion with review of literature.
Nandini NM, Rekha TS, Manjunath GV
Indian J Cancer 2011 Apr-Jun;48(2):240-5. doi: 10.4103/0019-509X.82891. PMID: 21768674
Fertility treatment and risk of breast cancer.
Braga C, Negri E, La Vecchia C, Parazzini F, Dal Maso L, Franceschi S
Hum Reprod 1996 Feb;11(2):300-3. doi: 10.1093/humrep/11.2.300. PMID: 8671214
Hormone replacement treatment and breast cancer risk: a cooperative Italian study.
La Vecchia C, Negri E, Franceschi S, Favero A, Nanni O, Filiberti R, Conti E, Montella M, Veronesi A, Ferraroni M
Br J Cancer 1995 Jul;72(1):244-8. doi: 10.1038/bjc.1995.310. PMID: 7599060Free PMC Article

Recent clinical studies

Etiology

Ring Enhancement in Non-Neoplastic Breast Tissue on MRI During Neoadjuvant Chemotherapy for Breast Cancer: Incidence and Clinical Implications.
Oh J, Han BK, Ko EY, Ko ES, Choi JS, Kim H, Park YH, Kim JY
Acad Radiol 2023 Dec;30(12):2931-2939. Epub 2023 Apr 10 doi: 10.1016/j.acra.2023.03.008. PMID: 37045651
A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
Boni C, Laudanna C, Sorio C
Biomolecules 2022 Jan 6;12(1) doi: 10.3390/biom12010084. PMID: 35053232Free PMC Article
Metabolic pathways in obesity-related breast cancer.
Brown KA
Nat Rev Endocrinol 2021 Jun;17(6):350-363. Epub 2021 Apr 29 doi: 10.1038/s41574-021-00487-0. PMID: 33927368Free PMC Article
Mediterranean Diet and Breast Cancer Risk.
Turati F, Carioli G, Bravi F, Ferraroni M, Serraino D, Montella M, Giacosa A, Toffolutti F, Negri E, Levi F, La Vecchia C
Nutrients 2018 Mar 8;10(3) doi: 10.3390/nu10030326. PMID: 29518016Free PMC Article
How to approach breast lesions in children and adolescents.
Gao Y, Saksena MA, Brachtel EF, terMeulen DC, Rafferty EA
Eur J Radiol 2015 Jul;84(7):1350-64. Epub 2015 Apr 27 doi: 10.1016/j.ejrad.2015.04.011. PMID: 25958188

Diagnosis

Lipocalin-2: Structure, function, distribution and role in metabolic disorders.
Jaberi SA, Cohen A, D'Souza C, Abdulrazzaq YM, Ojha S, Bastaki S, Adeghate EA
Biomed Pharmacother 2021 Oct;142:112002. Epub 2021 Aug 27 doi: 10.1016/j.biopha.2021.112002. PMID: 34463264
microRNA-140: A miRNA with diverse roles in human diseases.
Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses.
Naeem M, Zulfiqar M, Ballard DH, Billadello L, Cao G, Winter A, Lowdermilk M
Clin Imaging 2020 Oct;66:111-120. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.039. PMID: 32470708Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
How to approach breast lesions in children and adolescents.
Gao Y, Saksena MA, Brachtel EF, terMeulen DC, Rafferty EA
Eur J Radiol 2015 Jul;84(7):1350-64. Epub 2015 Apr 27 doi: 10.1016/j.ejrad.2015.04.011. PMID: 25958188

Therapy

Mechanism-Based Sonodynamic-Chemo Combinations against Triple-Negative Breast Cancer.
Feng X, Wu C, Yang W, Wu J, Wang P
Int J Mol Sci 2022 Jul 20;23(14) doi: 10.3390/ijms23147981. PMID: 35887326Free PMC Article
Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update.
Roskoski R Jr
Pharmacol Res 2020 Feb;152:104609. Epub 2019 Dec 17 doi: 10.1016/j.phrs.2019.104609. PMID: 31862477
Achieving Reliable Diagnosis in Late Breast Implant Seromas: From Reactive to Anaplastic Large Cell Lymphoma.
Di Napoli A
Plast Reconstr Surg 2019 Mar;143(3S A Review of Breast Implant-Associated Anaplastic Large Cell Lymphoma):15S-22S. doi: 10.1097/PRS.0000000000005565. PMID: 30817552
Farnesyltransferase inhibitors: mechanism and applications.
Prendergast GC, Rane N
Expert Opin Investig Drugs 2001 Dec;10(12):2105-16. doi: 10.1517/13543784.10.12.2105. PMID: 11772308
Antiestrogens--tamoxifen, SERMs and beyond.
Dhingra K
Invest New Drugs 1999;17(3):285-311. doi: 10.1023/a:1006348907994. PMID: 10665480

Prognosis

Ring Enhancement in Non-Neoplastic Breast Tissue on MRI During Neoadjuvant Chemotherapy for Breast Cancer: Incidence and Clinical Implications.
Oh J, Han BK, Ko EY, Ko ES, Choi JS, Kim H, Park YH, Kim JY
Acad Radiol 2023 Dec;30(12):2931-2939. Epub 2023 Apr 10 doi: 10.1016/j.acra.2023.03.008. PMID: 37045651
microRNA-140: A miRNA with diverse roles in human diseases.
Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
MicroRNAs as biomarkers in pituitary tumors.
Di Ieva A, Butz H, Niamah M, Rotondo F, De Rosa S, Sav A, Yousef GM, Kovacs K, Cusimano MD
Neurosurgery 2014 Aug;75(2):181-9; discussion 188-9. doi: 10.1227/NEU.0000000000000369. PMID: 24739366
Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.
Mukhopadhyay P, Chakraborty S, Ponnusamy MP, Lakshmanan I, Jain M, Batra SK
Biochim Biophys Acta 2011 Apr;1815(2):224-40. Epub 2011 Jan 26 doi: 10.1016/j.bbcan.2011.01.001. PMID: 21277939Free PMC Article

Clinical prediction guides

Ring Enhancement in Non-Neoplastic Breast Tissue on MRI During Neoadjuvant Chemotherapy for Breast Cancer: Incidence and Clinical Implications.
Oh J, Han BK, Ko EY, Ko ES, Choi JS, Kim H, Park YH, Kim JY
Acad Radiol 2023 Dec;30(12):2931-2939. Epub 2023 Apr 10 doi: 10.1016/j.acra.2023.03.008. PMID: 37045651
microRNA-140: A miRNA with diverse roles in human diseases.
Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855
Mediterranean Diet and Breast Cancer Risk.
Turati F, Carioli G, Bravi F, Ferraroni M, Serraino D, Montella M, Giacosa A, Toffolutti F, Negri E, Levi F, La Vecchia C
Nutrients 2018 Mar 8;10(3) doi: 10.3390/nu10030326. PMID: 29518016Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
MicroRNAs as biomarkers in pituitary tumors.
Di Ieva A, Butz H, Niamah M, Rotondo F, De Rosa S, Sav A, Yousef GM, Kovacs K, Cusimano MD
Neurosurgery 2014 Aug;75(2):181-9; discussion 188-9. doi: 10.1227/NEU.0000000000000369. PMID: 24739366

Recent systematic reviews

Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring.
Luchini C, Pantanowitz L, Adsay V, Asa SL, Antonini P, Girolami I, Veronese N, Nottegar A, Cingarlini S, Landoni L, Brosens LA, Verschuur AV, Mattiolo P, Pea A, Mafficini A, Milella M, Niazi MK, Gurcan MN, Eccher A, Cree IA, Scarpa A
Mod Pathol 2022 Jun;35(6):712-720. Epub 2022 Mar 5 doi: 10.1038/s41379-022-01055-1. PMID: 35249100Free PMC Article

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