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Parotid Gland Sebaceous Lymphadenoma

MedGen UID:
233316
Concept ID:
C1335366
Neoplastic Process
Synonym: Sebaceous Lymphadenoma of the Parotid Gland

Definition

A rare, benign epithelial neoplasm that arises from the parotid gland. It is composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Patients present with a progressively enlarging and painless mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Sebaceous Lymphadenoma

Professional guidelines

PubMed

van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
ESMO Open 2022 Dec;7(6):100602. Epub 2022 Nov 2 doi: 10.1016/j.esmoop.2022.100602. PMID: 36567082Free PMC Article
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202

Recent clinical studies

Etiology

Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Moon PK, Tusty M, Megwalu UC
Am J Otolaryngol 2022 Mar-Apr;43(2):103296. Epub 2021 Dec 3 doi: 10.1016/j.amjoto.2021.103296. PMID: 34894452
Osborne RF
Oral Maxillofac Surg Clin North Am 2021 May;33(2):169-175. Epub 2021 Jan 19 doi: 10.1016/j.coms.2020.12.002. PMID: 33478916
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142

Diagnosis

Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266
Carlson ER, Schlieve T
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):125-144. doi: 10.1016/j.coms.2018.08.007. PMID: 30449524
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Kuan EC, Mallen-St Clair J, St John MA
Otolaryngol Clin North Am 2016 Apr;49(2):313-25. Epub 2016 Feb 20 doi: 10.1016/j.otc.2015.10.004. PMID: 26902978
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Castelli J, Thariat J, Benezery K, Hasbini A, Gery B, Berger A, Liem X, Guihard S, Chapet S, Thureau S, Auberdiac P, Pommier P, Ruffier A, Perrier L, Devillers A, Campillo-Gimenez B, de Crevoisier R
JAMA Oncol 2023 Aug 1;9(8):1056-1064. doi: 10.1001/jamaoncol.2023.1352. PMID: 37261806Free PMC Article
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Biau J, Nutting C, Langendijk JA, Frédéric-Moreau T, Thariat J, Piram L, Bellini R, Saroul N, Pham Dang N, O'Sullivan B, Giralt J, Blanchard P, Bourhis J, Lapeyre M
Radiother Oncol 2022 May;170:48-54. Epub 2022 Mar 11 doi: 10.1016/j.radonc.2022.03.005. PMID: 35288225
Moori PL, Rahman S
Br J Oral Maxillofac Surg 2021 Apr;59(3):272-280. Epub 2020 Aug 28 doi: 10.1016/j.bjoms.2020.08.103. PMID: 33280943
Komatsu H, Kumoi K, Inokuchi G, Hashimoto K, Nagao T, Otsuki N, Nibu KI
Auris Nasus Larynx 2020 Jun;47(3):481-484. Epub 2019 Jun 21 doi: 10.1016/j.anl.2019.05.006. PMID: 31230813

Prognosis

van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
ESMO Open 2022 Dec;7(6):100602. Epub 2022 Nov 2 doi: 10.1016/j.esmoop.2022.100602. PMID: 36567082Free PMC Article
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Košec A, Zurak K, Čupić H, Bedeković V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Oct;136(5):405-408. Epub 2019 Mar 12 doi: 10.1016/j.anorl.2018.01.013. PMID: 30876853
Gandolfi MM, Slattery W 3rd
Otolaryngol Clin North Am 2016 Apr;49(2):425-34. doi: 10.1016/j.otc.2015.12.001. PMID: 27040587
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article

Clinical prediction guides

Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Moon PK, Tusty M, Megwalu UC
Am J Otolaryngol 2022 Mar-Apr;43(2):103296. Epub 2021 Dec 3 doi: 10.1016/j.amjoto.2021.103296. PMID: 34894452
Komatsu H, Kumoi K, Inokuchi G, Hashimoto K, Nagao T, Otsuki N, Nibu KI
Auris Nasus Larynx 2020 Jun;47(3):481-484. Epub 2019 Jun 21 doi: 10.1016/j.anl.2019.05.006. PMID: 31230813
Gandolfi MM, Slattery W 3rd
Otolaryngol Clin North Am 2016 Apr;49(2):425-34. doi: 10.1016/j.otc.2015.12.001. PMID: 27040587
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article

Recent systematic reviews

Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Moori PL, Rahman S
Br J Oral Maxillofac Surg 2021 Apr;59(3):272-280. Epub 2020 Aug 28 doi: 10.1016/j.bjoms.2020.08.103. PMID: 33280943

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