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Pre-Malignant Skin Epithelial Lesion

MedGen UID:
233338
•Concept ID:
C1335463
•
Neoplastic Process

Definition

A term that refers to precancerous epithelial pathologic processes that affect the skin. [from NCI]

Recent clinical studies

Etiology

Retrospective clinicopathological study of 129 cancerous and 18 precancerous lesions of the eyelids in North-Western Greece.
Tzoutzos K, Batistatou A, Kitsos G, Liasko R, Stefanou D
Int Ophthalmol 2017 Feb;37(1):203-208. Epub 2016 May 21 doi: 10.1007/s10792-016-0258-8. PMID: 27209420
Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy.
Szeimies RM, Torezan L, Niwa A, Valente N, Unger P, Kohl E, Schreml S, Babilas P, Karrer S, Festa-Neto C
Br J Dermatol 2012 Jul;167(1):150-9. Epub 2012 Jun 1 doi: 10.1111/j.1365-2133.2012.10887.x. PMID: 22329784
Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients.
Dréno B, Euvrard S, Frances C, Moyse D, Nandeuil A
Eur J Dermatol 2007 Mar-Apr;17(2):140-5. Epub 2007 Mar 2 doi: 10.1684/ejd.2007.0127. PMID: 17337398

Diagnosis

Optical biopsy of epithelial cancers by optical coherence tomography (OCT).
Wessels R, De Bruin DM, Faber DJ, Van Leeuwen TG, Van Beurden M, Ruers TJ
Lasers Med Sci 2014 May;29(3):1297-305. Epub 2013 Mar 16 doi: 10.1007/s10103-013-1291-8. PMID: 23504262Free PMC Article
Non-melanocytic mimics of melanoma: part I: intraepidermal mimics.
Kamil ZS, Tong LC, Habeeb AA, Ghazarian D
J Clin Pathol 2009 Feb;62(2):120-7. Epub 2008 Oct 17 doi: 10.1136/jcp.2008.060863. PMID: 18930985
The enigmatic nature of apocrine breast lesions.
Zagorianakou P, Zagorianakou N, Stefanou D, Makrydimas G, Agnantis NJ
Virchows Arch 2006 May;448(5):525-31. Epub 2006 Mar 29 doi: 10.1007/s00428-005-0095-z. PMID: 16570182

Therapy

Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy.
Szeimies RM, Torezan L, Niwa A, Valente N, Unger P, Kohl E, Schreml S, Babilas P, Karrer S, Festa-Neto C
Br J Dermatol 2012 Jul;167(1):150-9. Epub 2012 Jun 1 doi: 10.1111/j.1365-2133.2012.10887.x. PMID: 22329784
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.
Serrels B, Serrels A, Mason SM, Baldeschi C, Ashton GH, Canel M, Mackintosh LJ, Doyle B, Green TP, Frame MC, Sansom OJ, Brunton VG
Carcinogenesis 2009 Feb;30(2):249-57. Epub 2008 Dec 5 doi: 10.1093/carcin/bgn278. PMID: 19060248
Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients.
Dréno B, Euvrard S, Frances C, Moyse D, Nandeuil A
Eur J Dermatol 2007 Mar-Apr;17(2):140-5. Epub 2007 Mar 2 doi: 10.1684/ejd.2007.0127. PMID: 17337398

Prognosis

Photodynamic therapy for treatment of usual-type vulvar intraepithelial neoplasia: a case report and literature review.
Zhang R, Wang L
J Int Med Res 2019 Aug;47(8):4019-4026. Epub 2019 Jul 31 doi: 10.1177/0300060519862940. PMID: 31364444Free PMC Article

Clinical prediction guides

A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.
Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH, Tuong ZK
EBioMedicine 2016 Jul;9:314-323. Epub 2016 Jun 7 doi: 10.1016/j.ebiom.2016.06.011. PMID: 27333029Free PMC Article
Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy.
Szeimies RM, Torezan L, Niwa A, Valente N, Unger P, Kohl E, Schreml S, Babilas P, Karrer S, Festa-Neto C
Br J Dermatol 2012 Jul;167(1):150-9. Epub 2012 Jun 1 doi: 10.1111/j.1365-2133.2012.10887.x. PMID: 22329784
HPV-DNA is not detectable in outgrowing cells from explant cultures of skin lesions established at the air-liquid-interface.
Boxman IL, Mulder LH, Vermeer BJ, Bavinck JN, ter Schegget J, Ponec M
J Med Virol 2000 Jul;61(3):281-8. doi: 10.1002/1096-9071(200007)61:3<281::aid-jmv1>3.0.co;2-p. PMID: 10861634

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