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Premalignant Neoplasm

MedGen UID:
233343
•Concept ID:
C1335472
•
Neoplastic Process

Definition

A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPremalignant Neoplasm

Professional guidelines

PubMed

Analysis of apoptosis-associated molecules Erythroid differentiation regulator 1, bcl-2 and p53 in actinic keratosis after treatment with ingenol mebutate.
Woo YR, Lim JH, Jeong SW, Cho DH, Park HJ
Exp Dermatol 2017 Nov;26(11):1012-1017. Epub 2017 Jul 3 doi: 10.1111/exd.13349. PMID: 28370377

Recent clinical studies

Etiology

Clinicopathologic characteristics and long-term prognosis of intraductal papillary neoplasm of the bile duct: a retrospective study.
Wu X, Li B, Zheng C
Eur J Med Res 2023 Mar 21;28(1):132. doi: 10.1186/s40001-023-01102-w. PMID: 36945047Free PMC Article
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Intraductal oncocytic papillary neoplasm arising in Peutz-Jeghers Syndrome bile duct: a unique case report.
Liu Q, Wang Z, Yu C, Zhu J, Liu C, Li X, Ren L, Li T
Diagn Pathol 2022 Dec 28;17(1):96. doi: 10.1186/s13000-022-01275-8. PMID: 36578081Free PMC Article
Parenchyma-sparing, local pancreatic head resection for premalignant and low-malignant neoplasms - A systematic review and meta-analysis.
Beger HG, Mayer B, Poch B
Am J Surg 2018 Dec;216(6):1182-1191. Epub 2018 Oct 16 doi: 10.1016/j.amjsurg.2018.10.003. PMID: 30366596
Gallbladder Polypoid-Lesions: What Are They and How Should They be Treated? A Single-Center Experience Based on 1446 Cholecystectomy Patients.
Xu A, Zhang Y, Hu H, Zhao G, Cai J, Huang A
J Gastrointest Surg 2017 Nov;21(11):1804-1812. Epub 2017 Jul 10 doi: 10.1007/s11605-017-3476-0. PMID: 28695432

Diagnosis

Clinicopathologic characteristics and long-term prognosis of intraductal papillary neoplasm of the bile duct: a retrospective study.
Wu X, Li B, Zheng C
Eur J Med Res 2023 Mar 21;28(1):132. doi: 10.1186/s40001-023-01102-w. PMID: 36945047Free PMC Article
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Intraductal oncocytic papillary neoplasm arising in Peutz-Jeghers Syndrome bile duct: a unique case report.
Liu Q, Wang Z, Yu C, Zhu J, Liu C, Li X, Ren L, Li T
Diagn Pathol 2022 Dec 28;17(1):96. doi: 10.1186/s13000-022-01275-8. PMID: 36578081Free PMC Article
Gallbladder Polypoid-Lesions: What Are They and How Should They be Treated? A Single-Center Experience Based on 1446 Cholecystectomy Patients.
Xu A, Zhang Y, Hu H, Zhao G, Cai J, Huang A
J Gastrointest Surg 2017 Nov;21(11):1804-1812. Epub 2017 Jul 10 doi: 10.1007/s11605-017-3476-0. PMID: 28695432
Cytogenetic response to G2-phase X irradiation in relation to DNA repair and radiosensitivity in a cancer-prone family with Li-Fraumeni syndrome.
Parshad R, Price FM, Pirollo KF, Chang EH, Sanford KK
Radiat Res 1993 Nov;136(2):236-40. PMID: 8248481

Therapy

The impact of adjunctive metformin to progesterone for the treatment of non-atypical endometrial hyperplasia in a randomized fashion, a placebo-controlled, double blind clinical trial.
Tehranian A, Ghahghaei-Nezamabadi A, Arab M, Khalagi K, Aghajani R, Sadeghi S
J Gynecol Obstet Hum Reprod 2021 Jun;50(6):101863. Epub 2020 Jul 8 doi: 10.1016/j.jogoh.2020.101863. PMID: 32652300
Analysis of apoptosis-associated molecules Erythroid differentiation regulator 1, bcl-2 and p53 in actinic keratosis after treatment with ingenol mebutate.
Woo YR, Lim JH, Jeong SW, Cho DH, Park HJ
Exp Dermatol 2017 Nov;26(11):1012-1017. Epub 2017 Jul 3 doi: 10.1111/exd.13349. PMID: 28370377

Prognosis

Clinicopathologic characteristics and long-term prognosis of intraductal papillary neoplasm of the bile duct: a retrospective study.
Wu X, Li B, Zheng C
Eur J Med Res 2023 Mar 21;28(1):132. doi: 10.1186/s40001-023-01102-w. PMID: 36945047Free PMC Article
Gallbladder Polypoid-Lesions: What Are They and How Should They be Treated? A Single-Center Experience Based on 1446 Cholecystectomy Patients.
Xu A, Zhang Y, Hu H, Zhao G, Cai J, Huang A
J Gastrointest Surg 2017 Nov;21(11):1804-1812. Epub 2017 Jul 10 doi: 10.1007/s11605-017-3476-0. PMID: 28695432
Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms.
Fang SY, Jin YT, Ohyama M
Anticancer Res 1997 Sep-Oct;17(5A):3691-6. PMID: 9413225

Clinical prediction guides

Parenchyma-sparing, local pancreatic head resection for premalignant and low-malignant neoplasms - A systematic review and meta-analysis.
Beger HG, Mayer B, Poch B
Am J Surg 2018 Dec;216(6):1182-1191. Epub 2018 Oct 16 doi: 10.1016/j.amjsurg.2018.10.003. PMID: 30366596
Gallbladder Polypoid-Lesions: What Are They and How Should They be Treated? A Single-Center Experience Based on 1446 Cholecystectomy Patients.
Xu A, Zhang Y, Hu H, Zhao G, Cai J, Huang A
J Gastrointest Surg 2017 Nov;21(11):1804-1812. Epub 2017 Jul 10 doi: 10.1007/s11605-017-3476-0. PMID: 28695432
Analysis of apoptosis-associated molecules Erythroid differentiation regulator 1, bcl-2 and p53 in actinic keratosis after treatment with ingenol mebutate.
Woo YR, Lim JH, Jeong SW, Cho DH, Park HJ
Exp Dermatol 2017 Nov;26(11):1012-1017. Epub 2017 Jul 3 doi: 10.1111/exd.13349. PMID: 28370377
Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms.
Fang SY, Jin YT, Ohyama M
Anticancer Res 1997 Sep-Oct;17(5A):3691-6. PMID: 9413225

Recent systematic reviews

Parenchyma-sparing, local pancreatic head resection for premalignant and low-malignant neoplasms - A systematic review and meta-analysis.
Beger HG, Mayer B, Poch B
Am J Surg 2018 Dec;216(6):1182-1191. Epub 2018 Oct 16 doi: 10.1016/j.amjsurg.2018.10.003. PMID: 30366596

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