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Spinal cord sarcoma

MedGen UID:
233459
•Concept ID:
C1336049
•
Neoplastic Process
Synonyms: Sarcoma of Spinal Cord; sarcoma of spinal cord; Sarcoma of the Spinal Cord; sarcoma of the spinal cord; Spinal Cord Sarcoma; spinal cord sarcoma
 
Monarch Initiative: MONDO:0001894

Definition

A sarcoma that arises from the spinal cord. [from NCI]

Professional guidelines

PubMed

ACR Appropriateness Criteria® Malignant or Aggressive Primary Musculoskeletal Tumor-Staging and Surveillance: 2022 Update.
Expert Panel on Musculoskeletal Imaging, Stanborough R, Demertzis JL, Wessell DE, Lenchik L, Ahlawat S, Baker JC, Banks J, Caracciolo JT, Garner HW, Hentz C, Lewis VO, Lu Y, Maynard JR, Pierce JL, Scott JA, Sharma A, Beaman FD
J Am Coll Radiol 2022 Nov;19(11S):S374-S389. doi: 10.1016/j.jacr.2022.09.015. PMID: 36436964
Multimodality treatment of intradural extramedullary Ewing's sarcomas. A systematic review.
Paterakis KN, Brotis A, Dardiotis E, Giannis T, Tzerefos C, Fountas KN
Clin Neurol Neurosurg 2018 Jan;164:169-181. Epub 2017 Dec 7 doi: 10.1016/j.clineuro.2017.11.014. PMID: 29247908
Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature.
Sharafuddin MJ, Haddad FS, Hitchon PW, Haddad SF, el-Khoury GY
Neurosurgery 1992 Apr;30(4):610-8; discussion 618-9. PMID: 1374853

Recent clinical studies

Etiology

Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis.
Lv Y, Wu L, Jian H, Zhang C, Lou Y, Kang Y, Hou M, Li Z, Li X, Sun B, Zhou H
Front Immunol 2022;13:997765. Epub 2022 Oct 5 doi: 10.3389/fimmu.2022.997765. PMID: 36275664Free PMC Article
Modern Therapy for Spinal and Paraspinal Ewing Sarcoma: An Update of the University of Florida Experience.
Indelicato DJ, Vega RBM, Viviers E, Morris CG, Bradfield SM, Ranalli NJ, Bradley JA
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):161-165. Epub 2022 Jan 13 doi: 10.1016/j.ijrobp.2022.01.007. PMID: 35033584
Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms.
Sloan EA, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Raffel C, Berger MS, Chang SM, Reddy A, Ramani B, Ferris SP, Lee JC, Hofmann JW, Cho SJ, Horvai AE, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, Solomon DA
Brain Pathol 2021 Jul;31(4):e12918. Epub 2021 Jan 28 doi: 10.1111/bpa.12918. PMID: 33141488Free PMC Article
The prion-like nature of amyotrophic lateral sclerosis.
McAlary L, Yerbury JJ, Cashman NR
Prog Mol Biol Transl Sci 2020;175:261-296. Epub 2020 Sep 1 doi: 10.1016/bs.pmbts.2020.07.002. PMID: 32958236
Spinal Ewing Sarcoma Debuting with Cord Compression: Have We Discovered the Thread of Ariadne?
Boussios S, Hayward C, Cooke D, Zakynthinakis-Kyriakou N, Tsiouris AK, Chatziantoniou AA, Kanellos FS, Karathanasi A
Anticancer Res 2018 Oct;38(10):5589-5597. doi: 10.21873/anticanres.12893. PMID: 30275176

Diagnosis

Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis.
Lv Y, Wu L, Jian H, Zhang C, Lou Y, Kang Y, Hou M, Li Z, Li X, Sun B, Zhou H
Front Immunol 2022;13:997765. Epub 2022 Oct 5 doi: 10.3389/fimmu.2022.997765. PMID: 36275664Free PMC Article
ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases.
Oldenburger E, Brown S, Willmann J, van der Velden JM, Spałek M, van der Linden YM, Kazmierska J, Menten J, Andratschke N, Hoskin P
Radiother Oncol 2022 Aug;173:240-253. Epub 2022 Jun 7 doi: 10.1016/j.radonc.2022.06.002. PMID: 35688398
ESTRO ACROP guidelines for external beam radiotherapy of patients with uncomplicated bone metastases.
van der Velden J, Willmann J, Spałek M, Oldenburger E, Brown S, Kazmierska J, Andratschke N, Menten J, van der Linden Y, Hoskin P
Radiother Oncol 2022 Aug;173:197-206. Epub 2022 May 31 doi: 10.1016/j.radonc.2022.05.024. PMID: 35661676
Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms.
Sloan EA, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Raffel C, Berger MS, Chang SM, Reddy A, Ramani B, Ferris SP, Lee JC, Hofmann JW, Cho SJ, Horvai AE, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, Solomon DA
Brain Pathol 2021 Jul;31(4):e12918. Epub 2021 Jan 28 doi: 10.1111/bpa.12918. PMID: 33141488Free PMC Article
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Therapy

Modern Therapy for Spinal and Paraspinal Ewing Sarcoma: An Update of the University of Florida Experience.
Indelicato DJ, Vega RBM, Viviers E, Morris CG, Bradfield SM, Ranalli NJ, Bradley JA
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):161-165. Epub 2022 Jan 13 doi: 10.1016/j.ijrobp.2022.01.007. PMID: 35033584
Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis.
Ito D
Ann Neurol 2022 Jan;91(1):13-20. Epub 2021 Nov 20 doi: 10.1002/ana.26259. PMID: 34704267
Spinal sarcomas and immunity: An undervalued relationship.
Moussalem CK, Massaad E, Baassiri W, Akhtar Anwar M, Kobeissy F, Eid A, Darwiche N, Omeis I
Semin Cancer Biol 2020 Aug;64:36-50. Epub 2019 Jun 26 doi: 10.1016/j.semcancer.2019.06.009. PMID: 31254615
Epidural spinal cord compression.
Spinazzé S, Caraceni A, Schrijvers D
Crit Rev Oncol Hematol 2005 Dec;56(3):397-406. doi: 10.1016/j.critrevonc.2005.04.005. PMID: 16310372
Pelvic cancer pain.
Rigor BM Sr
J Surg Oncol 2000 Dec;75(4):280-300. doi: 10.1002/1096-9098(200012)75:4<280::aid-jso13>3.0.co;2-q. PMID: 11135274

Prognosis

Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis.
Lv Y, Wu L, Jian H, Zhang C, Lou Y, Kang Y, Hou M, Li Z, Li X, Sun B, Zhou H
Front Immunol 2022;13:997765. Epub 2022 Oct 5 doi: 10.3389/fimmu.2022.997765. PMID: 36275664Free PMC Article
The basic characteristics of extracellular vesicles and their potential application in bone sarcomas.
Li S
J Nanobiotechnology 2021 Sep 17;19(1):277. doi: 10.1186/s12951-021-01028-7. PMID: 34535153Free PMC Article
Spinal sarcomas and immunity: An undervalued relationship.
Moussalem CK, Massaad E, Baassiri W, Akhtar Anwar M, Kobeissy F, Eid A, Darwiche N, Omeis I
Semin Cancer Biol 2020 Aug;64:36-50. Epub 2019 Jun 26 doi: 10.1016/j.semcancer.2019.06.009. PMID: 31254615
Spinal Ewing Sarcoma Debuting with Cord Compression: Have We Discovered the Thread of Ariadne?
Boussios S, Hayward C, Cooke D, Zakynthinakis-Kyriakou N, Tsiouris AK, Chatziantoniou AA, Kanellos FS, Karathanasi A
Anticancer Res 2018 Oct;38(10):5589-5597. doi: 10.21873/anticanres.12893. PMID: 30275176
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Clinical prediction guides

Other Nerve Sheath Tumors of Brain and Spinal Cord.
Petrov M, Sakelarova T, Gerganov V
Adv Exp Med Biol 2023;1405:363-376. doi: 10.1007/978-3-031-23705-8_13. PMID: 37452945
Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis.
Lv Y, Wu L, Jian H, Zhang C, Lou Y, Kang Y, Hou M, Li Z, Li X, Sun B, Zhou H
Front Immunol 2022;13:997765. Epub 2022 Oct 5 doi: 10.3389/fimmu.2022.997765. PMID: 36275664Free PMC Article
Imaging of Spinal Bone Tumors: Principles and Practice.
Tsukamoto S, Mavrogenis AF, Langevelde KV, Vucht NV, Kido A, Errani C
Curr Med Imaging 2022;18(2):142-161. doi: 10.2174/1573405617666210301110446. PMID: 33645487
Intramedullary spinal cord metastases: Report of three cases and review of the literature.
Hommadi M, Belemlih M, Marnouch E, Maghous A, Zaghba N, Hamidi FZ, Bazzine A, Saghir KA, Elmarjany M, Sifat H, Hadadi K, Mansouri H
Cancer Radiother 2021 Apr;25(2):169-174. Epub 2021 Jan 9 doi: 10.1016/j.canrad.2020.10.003. PMID: 33436284
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Recent systematic reviews

Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
Quraishi NA, Palliyil N, Hassanin MA, D'Aquino D, Shetaiwi A, Walker D
Eur Spine J 2023 Dec;32(12):4306-4313. Epub 2023 Jun 20 doi: 10.1007/s00586-023-07820-3. PMID: 37338630
Systematic Review of Published Cases of Primary Epithelioid Sarcoma of the Spine.
Hu W, Wu X, Ma H, Wang H, Shi X, Zhang K, Gao Y
Med Sci Monit 2023 Jan 6;29:e938416. doi: 10.12659/MSM.938416. PMID: 36604864Free PMC Article
Viral infection and glioma: a meta-analysis of prognosis.
Cai Z, Yang S, Li X, Chen F, Li W
BMC Cancer 2020 Jun 12;20(1):549. doi: 10.1186/s12885-020-06796-3. PMID: 32532243Free PMC Article
Primary intradural Ewing's sarcoma of the spine: a systematic review of the literature.
Lu VM, Goyal A, Alvi MA, Kerezoudis P, Haddock MG, Bydon M
Clin Neurol Neurosurg 2019 Feb;177:12-19. Epub 2018 Dec 14 doi: 10.1016/j.clineuro.2018.12.011. PMID: 30579048
Multimodality treatment of intradural extramedullary Ewing's sarcomas. A systematic review.
Paterakis KN, Brotis A, Dardiotis E, Giannis T, Tzerefos C, Fountas KN
Clin Neurol Neurosurg 2018 Jan;164:169-181. Epub 2017 Dec 7 doi: 10.1016/j.clineuro.2017.11.014. PMID: 29247908

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