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Sporadic breast cancer

MedGen UID:
233463
•Concept ID:
C1336076
•
Neoplastic Process
Synonyms: Sporadic Breast Cancer; sporadic breast cancer; Sporadic Breast Carcinoma; sporadic breast carcinoma
 
Monarch Initiative: MONDO:0004438

Definition

A carcinoma that arises from the breast and is not caused by inherited genetic mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSporadic breast cancer

Professional guidelines

PubMed

BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
Breast cancer in BRCA mutation carriers: medical treatment.
Milani A, Geuna E, Zucchini G, Aversa C, Martinello R, Montemurro F
Minerva Ginecol 2016 Oct;68(5):557-65. Epub 2016 Jan 22 PMID: 26799758

Recent clinical studies

Etiology

Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy.
Ali RMM, McIntosh SA, Savage KI
Genes Chromosomes Cancer 2021 May;60(5):358-372. Epub 2020 Dec 9 doi: 10.1002/gcc.22921. PMID: 33247475
Preneoplasia of the Breast and Molecular Landscape.
Alvarado-Cabrero I, Valencia-Cedillo R, Estevez-Castro R
Arch Med Res 2020 Nov;51(8):845-850. Epub 2020 Sep 21 doi: 10.1016/j.arcmed.2020.09.011. PMID: 32972772
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
BRCA1 as target for breast cancer prevention and therapy.
Romagnolo AP, Romagnolo DF, Selmin OI
Anticancer Agents Med Chem 2015;15(1):4-14. doi: 10.2174/1871520614666141020153543. PMID: 25329591

Diagnosis

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
Sporadic and Hereditary Breast Cancer Genetics.
Zehr KR
Radiol Technol 2018 Sep;90(1):51M-64M. PMID: 30352929
Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
Genotoxins and the initiation of sporadic breast cancer.
Martin FL
Mutagenesis 2001 Mar;16(2):155-61. doi: 10.1093/mutage/16.2.155. PMID: 11230559
Maternal and prepubertal diet, mammary development and breast cancer risk.
Hilakivi-Clarke L, Cho E, deAssis S, Olivo S, Ealley E, Bouker KB, Welch JN, Khan G, Clarke R, Cabanes A
J Nutr 2001 Jan;131(1):154S-157S. doi: 10.1093/jn/131.1.154S. PMID: 11208953

Therapy

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds.
Romagnolo DF, Daniels KD, Grunwald JT, Ramos SA, Propper CR, Selmin OI
Mol Nutr Food Res 2016 Jun;60(6):1310-29. doi: 10.1002/mnfr.201501063. PMID: 27144894Free PMC Article
BRCA1 as target for breast cancer prevention and therapy.
Romagnolo AP, Romagnolo DF, Selmin OI
Anticancer Agents Med Chem 2015;15(1):4-14. doi: 10.2174/1871520614666141020153543. PMID: 25329591

Prognosis

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
Tumor characteristics and prognosis in familial breast cancer.
Arpino G, Pensabene M, Condello C, Ruocco R, Cerillo I, Lauria R, Forestieri V, Giuliano M, De Angelis C, Montella M, Crispo A, De Placido S
BMC Cancer 2016 Nov 29;16(1):924. doi: 10.1186/s12885-016-2962-1. PMID: 27899083Free PMC Article
MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency.
Ren J, Jin F, Yu Z, Zhao L, Wang L, Bai X, Zhao H, Yao W, Mi X, Wang E, Olopade OI, Wei M
Tumour Biol 2013 Dec;34(6):3945-58. Epub 2013 Jul 17 doi: 10.1007/s13277-013-0983-9. PMID: 23860775

Clinical prediction guides

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis.
Pietrasik S, Zajac G, Morawiec J, Soszynski M, Fila M, Blasiak J
Int J Mol Sci 2020 Jan 29;21(3) doi: 10.3390/ijms21030870. PMID: 32013256Free PMC Article
Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds.
Romagnolo DF, Daniels KD, Grunwald JT, Ramos SA, Propper CR, Selmin OI
Mol Nutr Food Res 2016 Jun;60(6):1310-29. doi: 10.1002/mnfr.201501063. PMID: 27144894Free PMC Article
Genotoxins and the initiation of sporadic breast cancer.
Martin FL
Mutagenesis 2001 Mar;16(2):155-61. doi: 10.1093/mutage/16.2.155. PMID: 11230559
The ATM gene and breast cancer: is it really a risk factor?
Angèle S, Hall J
Mutat Res 2000 Apr;462(2-3):167-78. doi: 10.1016/s1383-5742(00)00034-x. PMID: 10767628

Recent systematic reviews

Does breast-conserving surgery with radiotherapy in BRCA-mutation carriers significantly increase ipsilateral breast tumor recurrence? A systematic review and meta-analysis.
Nara M, Ishihara S, Kitano A, Tamura N, Aruga T, Kobayashi D, Nakamura S, Yamauchi H
Breast Cancer 2022 May;29(3):394-401. Epub 2022 Feb 25 doi: 10.1007/s12282-022-01343-3. PMID: 35212965
Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - A systematic review and meta-analysis.
Davey MG, Davey CM, Ryan ÉJ, Lowery AJ, Kerin MJ
Breast 2021 Apr;56:26-34. Epub 2021 Feb 4 doi: 10.1016/j.breast.2021.02.001. PMID: 33582622Free PMC Article
Breast Conserving Surgery for BRCA Mutation Carriers-A Systematic Review.
Co M, Liu T, Leung J, Li CH, Tse T, Wong M, Kwong A
Clin Breast Cancer 2020 Jun;20(3):e244-e250. Epub 2019 Aug 22 doi: 10.1016/j.clbc.2019.07.014. PMID: 32144082
Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies.
Dashti S, Taherian-Esfahani Z, Keshtkar A, Ghafouri-Fard S
BMC Med Genet 2019 May 10;20(1):79. doi: 10.1186/s12881-019-0809-8. PMID: 31077156Free PMC Article
Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer.
Henderson TO, Amsterdam A, Bhatia S, Hudson MM, Meadows AT, Neglia JP, Diller LR, Constine LS, Smith RA, Mahoney MC, Morris EA, Montgomery LL, Landier W, Smith SM, Robison LL, Oeffinger KC
Ann Intern Med 2010 Apr 6;152(7):444-55; W144-54. doi: 10.7326/0003-4819-152-7-201004060-00009. PMID: 20368650Free PMC Article

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