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Infectious mononucleosis-like post-transplant lymphoproliferative disorder

MedGen UID:
233551
•Concept ID:
C1334174
•
Disease or Syndrome
Synonyms: Infectious Mononucleosis-Like Post-Transplant Lymphoproliferative Disorder; Infectious Mononucleosis-like PTLD
SNOMED CT: Infectious mononucleosis-like post-transplant lymphoproliferative disorder (722958008)

Definition

An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis. There is architectural preservation of the involved tissues. Oligoclonal or monoclonal cellular populations have been detected in a small number of cases. In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious mononucleosis-like post-transplant lymphoproliferative disorder

Recent clinical studies

Etiology

Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399
Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease.
Campe H, Jaeger G, Abou-Ajram C, Nitschko H, Griebel M, Montoya C, Klare B, Koszinowski U
Pediatr Transplant 2003 Feb;7(1):46-52. doi: 10.1034/j.1399-3046.2003.02051.x. PMID: 12581328
Posttransplantation lymphoproliferative disorder in a renal allograft recipient.
Goral S, Felgar R, Shappell S
Am J Kidney Dis 1997 Aug;30(2):301-7. doi: 10.1016/s0272-6386(97)90071-8. PMID: 9261047

Diagnosis

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.
Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A
Int J Infect Dis 2019 Nov;88:31-33. Epub 2019 Aug 6 doi: 10.1016/j.ijid.2019.07.039. PMID: 31398454
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399
Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease.
Campe H, Jaeger G, Abou-Ajram C, Nitschko H, Griebel M, Montoya C, Klare B, Koszinowski U
Pediatr Transplant 2003 Feb;7(1):46-52. doi: 10.1034/j.1399-3046.2003.02051.x. PMID: 12581328
Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity?
Nelson BP, Nalesnik MA, Bahler DW, Locker J, Fung JJ, Swerdlow SH
Am J Surg Pathol 2000 Mar;24(3):375-85. doi: 10.1097/00000478-200003000-00006. PMID: 10716151

Therapy

Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399
Post-transplant multiple myeloma in a pediatric renal transplant patient.
Tcheng WY, Said J, Hall T, Al-Akash S, Malogolowkin M, Feig SA
Pediatr Blood Cancer 2006 Aug;47(2):218-23. doi: 10.1002/pbc.20482. PMID: 16086426
Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease.
Campe H, Jaeger G, Abou-Ajram C, Nitschko H, Griebel M, Montoya C, Klare B, Koszinowski U
Pediatr Transplant 2003 Feb;7(1):46-52. doi: 10.1034/j.1399-3046.2003.02051.x. PMID: 12581328
Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity?
Nelson BP, Nalesnik MA, Bahler DW, Locker J, Fung JJ, Swerdlow SH
Am J Surg Pathol 2000 Mar;24(3):375-85. doi: 10.1097/00000478-200003000-00006. PMID: 10716151

Prognosis

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.
Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A
Int J Infect Dis 2019 Nov;88:31-33. Epub 2019 Aug 6 doi: 10.1016/j.ijid.2019.07.039. PMID: 31398454
Development of an Epstein-Barr virus-associated lymphoproliferative disorder in a patient treated with azacitidine for chronic myelomonocytic leukaemia.
Menter T, Schlageter M, Bastian L, Haberthür R, Rätz Bravo AE, Tzankov A
Hematol Oncol 2014 Mar;32(1):47-51. Epub 2013 Apr 29 doi: 10.1002/hon.2054. PMID: 23625339
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant multiple myeloma in a pediatric renal transplant patient.
Tcheng WY, Said J, Hall T, Al-Akash S, Malogolowkin M, Feig SA
Pediatr Blood Cancer 2006 Aug;47(2):218-23. doi: 10.1002/pbc.20482. PMID: 16086426

Clinical prediction guides

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.
Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H
Nat Microbiol 2019 Mar;4(3):404-413. Epub 2019 Jan 21 doi: 10.1038/s41564-018-0334-0. PMID: 30664667
Development of an Epstein-Barr virus-associated lymphoproliferative disorder in a patient treated with azacitidine for chronic myelomonocytic leukaemia.
Menter T, Schlageter M, Bastian L, Haberthür R, Rätz Bravo AE, Tzankov A
Hematol Oncol 2014 Mar;32(1):47-51. Epub 2013 Apr 29 doi: 10.1002/hon.2054. PMID: 23625339
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160

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