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Infectious Mononucleosis Post-Transplant Lymphoproliferative Disorder

MedGen UID:
233551
•Concept ID:
C1334174
•
Neoplastic Process
Synonyms: Infectious Mononucleosis PTLD; Infectious mononucleosis-like post-transplant lymphoproliferative disorder; Infectious Mononucleosis-Like Post-Transplant Lymphoproliferative Disorder; Infectious Mononucleosis-like PTLD
SNOMED CT: Infectious mononucleosis-like post-transplant lymphoproliferative disorder (722958008)

Definition

An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis. There is architectural preservation of the involved tissues. Oligoclonal or monoclonal cellular populations have been detected in a small number of cases. In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious Mononucleosis Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Treatment of Epstein-Barr Virus infection in immunocompromised patients.
Pociupany M, Snoeck R, Dierickx D, Andrei G
Biochem Pharmacol 2024 Jul;225:116270. Epub 2024 May 10 doi: 10.1016/j.bcp.2024.116270. PMID: 38734316

Recent clinical studies

Etiology

Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult.
Chen DB, Liu XY, Kong FZ, Jiang Q, Shen DH
J Clin Pathol 2021 Nov;74(11):697-703. Epub 2021 May 19 doi: 10.1136/jclinpath-2021-207492. PMID: 34011618
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399

Diagnosis

Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56(dim)NKG2A(+)KIR(-) NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder.
Lam JKP, Azzi T, Hui KF, Wong AMG, McHugh D, Caduff N, Chan KH, Münz C, Chiang AKS
Front Immunol 2020;11:1231. Epub 2020 Jun 17 doi: 10.3389/fimmu.2020.01231. PMID: 32625211Free PMC Article
Epstein-Barr Virus and Cytomegalovirus Infections of the Liver.
Bunchorntavakul C, Reddy KR
Gastroenterol Clin North Am 2020 Jun;49(2):331-346. doi: 10.1016/j.gtc.2020.01.008. PMID: 32389366
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399

Therapy

Treatment of Epstein-Barr Virus infection in immunocompromised patients.
Pociupany M, Snoeck R, Dierickx D, Andrei G
Biochem Pharmacol 2024 Jul;225:116270. Epub 2024 May 10 doi: 10.1016/j.bcp.2024.116270. PMID: 38734316
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases.
Cui X, Snapper CM
Front Immunol 2021;12:734471. Epub 2021 Oct 8 doi: 10.3389/fimmu.2021.734471. PMID: 34691042Free PMC Article
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Post-transplant lymphoproliferative disease in liver transplantation.
Dhillon MS, Rai JK, Gunson BK, Olliff S, Olliff J
Br J Radiol 2007 May;80(953):337-46. Epub 2007 Mar 28 doi: 10.1259/bjr/63272556. PMID: 17392399

Prognosis

Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult.
Chen DB, Liu XY, Kong FZ, Jiang Q, Shen DH
J Clin Pathol 2021 Nov;74(11):697-703. Epub 2021 May 19 doi: 10.1136/jclinpath-2021-207492. PMID: 34011618
Epstein-Barr virus latent gene EBNA-1 genetic diversity among transplant patients compared with patients with infectious mononucleosis.
Sullivan K, Isabel S, Khodai-Booran N, Paton TA, Abdulnoor M, Dipchand AI, Hébert D, Ng VL, Allen UD
Clin Transplant 2019 Apr;33(4):e13504. Epub 2019 Apr 1 doi: 10.1111/ctr.13504. PMID: 30790353
Interleukin 28B gene polymorphisms and Epstein-Barr virus-associated lymphoproliferative diseases.
Akay E, Patel M, Conibear T, Chaggar T, Haque T
Intervirology 2014;57(2):112-5. Epub 2014 Jan 25 doi: 10.1159/000357326. PMID: 24480970
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160
Post-transplant multiple myeloma in a pediatric renal transplant patient.
Tcheng WY, Said J, Hall T, Al-Akash S, Malogolowkin M, Feig SA
Pediatr Blood Cancer 2006 Aug;47(2):218-23. doi: 10.1002/pbc.20482. PMID: 16086426

Clinical prediction guides

Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult.
Chen DB, Liu XY, Kong FZ, Jiang Q, Shen DH
J Clin Pathol 2021 Nov;74(11):697-703. Epub 2021 May 19 doi: 10.1136/jclinpath-2021-207492. PMID: 34011618
Epstein-Barr virus latent gene EBNA-1 genetic diversity among transplant patients compared with patients with infectious mononucleosis.
Sullivan K, Isabel S, Khodai-Booran N, Paton TA, Abdulnoor M, Dipchand AI, Hébert D, Ng VL, Allen UD
Clin Transplant 2019 Apr;33(4):e13504. Epub 2019 Apr 1 doi: 10.1111/ctr.13504. PMID: 30790353
Defective Epstein-Barr virus in chronic active infection and haematological malignancy.
Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H
Nat Microbiol 2019 Mar;4(3):404-413. Epub 2019 Jan 21 doi: 10.1038/s41564-018-0334-0. PMID: 30664667
Plasma EBV microRNAs in paediatric renal transplant recipients.
Hassan J, Dean J, De Gascun CF, Riordan M, Sweeney C, Connell J, Awan A
J Nephrol 2018 Jun;31(3):445-451. Epub 2017 Nov 28 doi: 10.1007/s40620-017-0462-2. PMID: 29185211
Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
Chen DB, Song QJ, Chen YX, Chen YH, Shen DH
Int J Hematol 2013 Jan;97(1):117-24. Epub 2012 Dec 20 doi: 10.1007/s12185-012-1244-1. PMID: 23255160

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