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Central Nervous System Inflammatory Myofibroblastic Tumor

MedGen UID:
233555
Concept ID:
C1334183
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm affecting the central nervous system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Sreenivasan S, Agarwal N, Bharath Raju, Kandregula S, Narayan V, Chen CC, Sharma M
World Neurosurg 2023 Dec;180:194-202.e11. Epub 2023 Sep 13 doi: 10.1016/j.wneu.2023.09.026. PMID: 37708970

Recent clinical studies

Etiology

Nishadham V, Rao S, Saravanan A, Kulanthaivelu K, Vengalil S, Venkatappa HA, Valasani RK, Bardhan M, Pruti N, Nalini A, Mahadevan A
Clin Neuropathol 2023 May-Jun;42(3):100-111. doi: 10.5414/NP301540. PMID: 37051870
Tauziède-Espariat A, Pierre T, Wassef M, Castel D, Riant F, Grill J, Roux A, Pallud J, Dezamis E, Bresson D, Benichi S, Blauwblomme T, Benzohra D, Gauchotte G, Pouget C, Colnat-Coulbois S, Mokhtari K, Balleyguier C, Larousserie F, Dangouloff-Ros V, Boddaert N, Debily MA, Hasty L, Polivka M, Adle-Biassette H, Métais A, Lechapt E, Chrétien F, Sahm F, Sievers P, Varlet P; RENOCLIP-LOC
Acta Neuropathol Commun 2022 May 31;10(1):81. doi: 10.1186/s40478-022-01384-x. PMID: 35642047Free PMC Article
Kaneva K, Wadhwani N, DiPatri AJ Jr, Palasis S, Goldman S, Aw-Zoretic J
Childs Nerv Syst 2021 Feb;37(2):359-366. Epub 2020 Sep 2 doi: 10.1007/s00381-020-04874-2. PMID: 32876801
Wen JB, Huang WY, Xu WX, Wu G, Geng DY, Yin B
J Comput Assist Tomogr 2017 Nov/Dec;41(6):904-909. doi: 10.1097/RCT.0000000000000636. PMID: 28708728
Swain RS, Tihan T, Horvai AE, Di Vizio D, Loda M, Burger PC, Scheithauer BW, Kim GE
Hum Pathol 2008 Mar;39(3):410-9. doi: 10.1016/j.humpath.2007.07.012. PMID: 18261625

Diagnosis

Ramos JG, Ochoa A, Cicutti S, Del Rio R, Lubienieki F
Childs Nerv Syst 2023 May;39(5):1137-1145. Epub 2023 Apr 5 doi: 10.1007/s00381-023-05925-0. PMID: 37017800
Zemmoura I, Hamlat A, Morandi X
Eur Spine J 2011 Jul;20 Suppl 2(Suppl 2):S330-5. Epub 2011 Apr 6 doi: 10.1007/s00586-011-1783-9. PMID: 21465290Free PMC Article
Donev K, Scheithauer BW
Arch Pathol Lab Med 2010 Mar;134(3):404-16. doi: 10.5858/134.3.404. PMID: 20196668
Narla LD, Newman B, Spottswood SS, Narla S, Kolli R
Radiographics 2003 May-Jun;23(3):719-29. doi: 10.1148/rg.233025073. PMID: 12740472
Sitton JE, Harkin JC, Gerber MA
Clin Neuropathol 1992 Jan-Feb;11(1):36-40. PMID: 1547580

Therapy

Carcamo B, Bista R, Wilson H, Reddy P, Pacheco J
J Pediatr Hematol Oncol 2021 Jul 1;43(5):e718-e722. doi: 10.1097/MPH.0000000000002185. PMID: 34157012
Ward A, Konya C, Mark EJ, Rosen S
Am J Surg Pathol 2014 Oct;38(10):1444-8. doi: 10.1097/PAS.0000000000000294. PMID: 25025447
Moss HE, Mejico LJ, de la Roza G, Coyne TM, Galetta SL, Liu GT
J Neurol Sci 2012 Jul 15;318(1-2):31-5. Epub 2012 Apr 28 doi: 10.1016/j.jns.2012.04.010. PMID: 22546342Free PMC Article
Lui PC, Fan YS, Wong SS, Chan AN, Wong G, Chau TK, Tse GM, Cheng Y, Poon WS, Ng HK
Hum Pathol 2009 Nov;40(11):1611-7. Epub 2009 Aug 5 doi: 10.1016/j.humpath.2009.04.016. PMID: 19656549
Gilliard C, De Coene B, Lahdou JB, Boutsen Y, Noël H, Godfraind C
J Neurosurg 2000 Jul;93(1 Suppl):152-6. doi: 10.3171/spi.2000.93.1.0152. PMID: 10879775

Prognosis

Ramos JG, Ochoa A, Cicutti S, Del Rio R, Lubienieki F
Childs Nerv Syst 2023 May;39(5):1137-1145. Epub 2023 Apr 5 doi: 10.1007/s00381-023-05925-0. PMID: 37017800
Vidrine DW, Berry JF, Garbuzov A, Falcon C, Tubbs RS, Bui CJ
Childs Nerv Syst 2021 Jul;37(7):2147-2151. Epub 2021 May 20 doi: 10.1007/s00381-021-05219-3. PMID: 34014367
Kanagaraju V, Rai D, Alluri RV, Prasanna C, Shyam Sundar V, Arvind Kumar SM, Venkatesh Kumar N
Eur Spine J 2016 May;25 Suppl 1:75-9. Epub 2015 Jul 9 doi: 10.1007/s00586-015-4106-8. PMID: 26155896
Pascual-Gallego M, Yus-Fuertes M, Jorquera M, Gonzalez-Mat A, Ortega L, Martinez-Martinez A, Zimman H
Neurol India 2013 Nov-Dec;61(6):644-9. doi: 10.4103/0028-3886.125273. PMID: 24441334
Lin YJ, Yang TM, Lin JW, Song MZ, Lee TC
Surg Neurol 2009 Dec;72(6):712-6; discussion 716. Epub 2009 Jul 15 doi: 10.1016/j.surneu.2009.01.029. PMID: 19608242

Clinical prediction guides

Tang XL, Huang WJ, Ma Q, Yi KM
BMC Neurol 2022 Dec 2;22(1):448. doi: 10.1186/s12883-022-02993-8. PMID: 36460992Free PMC Article
Wang X, Chen Y, Wu X, Zhang H
World Neurosurg 2019 May;125:117-122. Epub 2019 Feb 5 doi: 10.1016/j.wneu.2019.01.155. PMID: 30735872
Yavuzer D, Dalbayrak S, Oz B, Yilmaz M, Akansel G
Clin Neuropathol 2010 May-Jun;29(3):151-5. doi: 10.5414/npp29151. PMID: 20423689
Häusler M, Schaade L, Ramaekers VT, Doenges M, Heimann G, Sellhaus B
Hum Pathol 2003 Mar;34(3):253-62. doi: 10.1053/hupa.2003.35. PMID: 12673560
Pimentel J, Costa A, Távora L
J Neurosurg 1993 Dec;79(6):939-42. doi: 10.3171/jns.1993.79.6.0939. PMID: 8246063

Recent systematic reviews

Sreenivasan S, Agarwal N, Bharath Raju, Kandregula S, Narayan V, Chen CC, Sharma M
World Neurosurg 2023 Dec;180:194-202.e11. Epub 2023 Sep 13 doi: 10.1016/j.wneu.2023.09.026. PMID: 37708970

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