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Lymphomatous Adult T-Cell Leukemia/Lymphoma

MedGen UID:
233634
Concept ID:
C1334466
Neoplastic Process
Synonym: Lymphomatous Adult T-Cell Lymphoma/Leukemia

Definition

An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement. Most patients have advanced disease, however hypercalcemia is not frequently present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphomatous Adult T-Cell Leukemia/Lymphoma

Professional guidelines

PubMed

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Recent clinical studies

Etiology

Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Rodríguez-Zúñiga MJM, Cortez-Franco F, Qujiano-Gomero E
Actas Dermosifiliogr (Engl Ed) 2018 Jun;109(5):399-407. Epub 2018 Apr 21 doi: 10.1016/j.ad.2017.08.014. PMID: 29685460
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article

Diagnosis

Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Munakata W, Tobinai K
Cancer Treat Res 2019;176:145-161. doi: 10.1007/978-3-319-99716-2_7. PMID: 30596217
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051
Qayyum S, Choi JK
Arch Pathol Lab Med 2014 Feb;138(2):282-6. doi: 10.5858/arpa.2012-0379-RS. PMID: 24476526
Matutes E
J Clin Pathol 2007 Dec;60(12):1373-7. doi: 10.1136/jcp.2007.052456. PMID: 18042693Free PMC Article

Therapy

Katsuya H
Int J Hematol 2023 Apr;117(4):512-522. Epub 2023 Mar 2 doi: 10.1007/s12185-023-03572-4. PMID: 36862273
Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Tsukasaki K
Hematology 2012 Apr;17 Suppl 1:S32-5. doi: 10.1179/102453312X13336169155330. PMID: 22507774

Prognosis

Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y, McClure MB, Tabata M, Shingaki S, Yoshifuji K, Chiba K, Okada A, Kakiuchi N, Nannya Y, Kamiunten A, Tahira Y, Akizuki K, Sekine M, Shide K, Hidaka T, Kubuki Y, Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Ramos JC, Shibata T, Takeuchi K, Takaori-Kondo A, Miyazaki Y, Matsuoka M, Ishitsuka K, Shiraishi Y, Miyano S, Ogawa S, Ye BH, Shimoda K, Kataoka K
Blood 2022 Feb 17;139(7):967-982. doi: 10.1182/blood.2021013568. PMID: 34695199Free PMC Article
Munakata W, Tobinai K
Cancer Treat Res 2019;176:145-161. doi: 10.1007/978-3-319-99716-2_7. PMID: 30596217
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051

Clinical prediction guides

Nakashima M, Uchimaru K
Int J Mol Sci 2023 May 13;24(10) doi: 10.3390/ijms24108731. PMID: 37240076Free PMC Article
Ohmoto A, Fuji S
Expert Rev Hematol 2023 Jul-Dec;16(7):535-541. Epub 2023 May 18 doi: 10.1080/17474086.2023.2215424. PMID: 37191476
Tamaki T, Karube K, Sakihama S, Tsuruta Y, Awazawa R, Hayashi M, Nakada N, Matsumoto H, Yagi N, Ohshiro K, Nakazato I, Kitamura S, Nishi Y, Miyagi T, Yamaguchi S, Nakachi S, Morishima S, Masuzaki H, Takahashi K, Fukushima T, Wada N
Mod Pathol 2023 Aug;36(8):100169. Epub 2023 Mar 29 doi: 10.1016/j.modpat.2023.100169. PMID: 36997002
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753

Recent systematic reviews

Elsallab M, Ellithi M, Hempel S, Abdel-Azim H, Abou-El-Enein M
Cancer Gene Ther 2023 Jun;30(6):845-854. Epub 2023 Feb 7 doi: 10.1038/s41417-023-00593-3. PMID: 36750666Free PMC Article
Nosaka K, Crawford B, Yi J, Kuan W, Matsumoto T, Takahashi T
Eur J Haematol 2022 Mar;108(3):212-222. Epub 2021 Dec 8 doi: 10.1111/ejh.13728. PMID: 34862665Free PMC Article
Grover P, Veilleux O, Tian L, Sun R, Previtera M, Curran E, Muffly L
Blood Adv 2022 Mar 8;6(5):1608-1618. doi: 10.1182/bloodadvances.2020003482. PMID: 34610109Free PMC Article
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Oliveira PD, de Carvalho RF, Bittencourt AL
Int J STD AIDS 2017 Mar;28(3):217-228. Epub 2016 Dec 14 doi: 10.1177/0956462416684461. PMID: 28178905

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