U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Major salivary gland carcinoma ex pleomorphic adenoma

MedGen UID:
233655
Concept ID:
C1334550
Neoplastic Process
Synonyms: Carcinoma ex Pleomorphic Adenoma of Major Salivary Gland; carcinoma ex pleomorphic adenoma of Major salivary gland; Carcinoma ex Pleomorphic Adenoma of the Major Salivary Gland; carcinoma ex pleomorphic adenoma of the Major salivary gland; Major Salivary Gland Carcinoma ex Pleomorphic Adenoma; major salivary gland carcinoma ex pleomorphic adenoma; major salivary gland salivary gland carcinoma ex pleomorphic adenoma
 
Monarch Initiative: MONDO:0006285

Definition

A carcinoma that arises from a pleomorphic adenoma in the major salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive. [from NCI]

Professional guidelines

PubMed

Eppsteiner RW, Fowlkes JW, Anderson CM, Robinson RA, Pagedar NA
Ann Otol Rhinol Laryngol 2017 Jul;126(7):525-529. Epub 2017 May 5 doi: 10.1177/0003489417702655. PMID: 28474964

Recent clinical studies

Etiology

Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660

Diagnosis

Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337

Therapy

Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
Otsuka H, Graham MM, Kogame M, Nishitani H
Ann Nucl Med 2005 Dec;19(8):691-4. doi: 10.1007/BF02985118. PMID: 16444995

Prognosis

Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Patel EJ, Oliver JR, Liu C, Tam M, Givi B
J Surg Oncol 2021 Feb;123(2):446-455. Epub 2020 Nov 4 doi: 10.1002/jso.26289. PMID: 33145786
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337

Clinical prediction guides

Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2019 Nov-Dec;40(6):102279. Epub 2019 Aug 21 doi: 10.1016/j.amjoto.2019.102279. PMID: 31471126
Xu B, Mneimneh W, Torrence DE, Higgins K, Klimstra D, Ghossein R, Katabi N
Am J Surg Pathol 2019 May;43(5):601-609. doi: 10.1097/PAS.0000000000001218. PMID: 30789358Free PMC Article
von Holstein SL, Fehr A, Persson M, Nickelsen M, Therkildsen MH, Prause JU, Heegaard S, Stenman G
Ophthalmology 2014 May;121(5):1125-33. Epub 2014 Jan 24 doi: 10.1016/j.ophtha.2013.11.037. PMID: 24468654
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660

Recent systematic reviews

Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...