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ACTH-producing pituitary gland carcinoma

MedGen UID:
233657
•Concept ID:
C1334556
•
Neoplastic Process
Synonyms: ACTH Producing Pituitary Gland Carcinoma; ACTH producing pituitary gland carcinoma; Malignant ACTH Producing Neoplasm of Pituitary; malignant ACTH producing neoplasm of pituitary; Malignant ACTH Producing Neoplasm of Pituitary Gland; malignant ACTH producing neoplasm of pituitary gland; Malignant ACTH Producing Neoplasm of the Pituitary; malignant ACTH producing neoplasm of the pituitary; Malignant ACTH Producing Neoplasm of the Pituitary Gland; malignant ACTH producing neoplasm of the pituitary gland; Malignant ACTH Producing Pituitary Gland Neoplasm; malignant ACTH producing pituitary gland neoplasm; Malignant ACTH Producing Pituitary Gland Tumor; malignant ACTH producing pituitary gland tumor; malignant ACTH producing pituitary gland tumour; Malignant ACTH Producing Pituitary Neoplasm; malignant ACTH producing pituitary neoplasm; Malignant ACTH Producing Pituitary Tumor; malignant ACTH producing pituitary tumor; malignant ACTH producing pituitary tumour; Malignant ACTH Producing Tumor of Pituitary; malignant ACTH producing tumor of pituitary; Malignant ACTH Producing Tumor of Pituitary Gland; malignant ACTH producing tumor of pituitary gland; Malignant ACTH Producing Tumor of the Pituitary; malignant ACTH producing tumor of the pituitary; Malignant ACTH Producing Tumor of the Pituitary Gland; malignant ACTH producing tumor of the pituitary gland; malignant ACTH producing tumour of pituitary; malignant ACTH producing tumour of pituitary gland; malignant ACTH producing tumour of the pituitary; malignant ACTH producing tumour of the pituitary gland; Malignant ACTH Secreting Neoplasm of Pituitary; malignant ACTH secreting neoplasm of pituitary; Malignant ACTH Secreting Neoplasm of Pituitary Gland; malignant ACTH secreting neoplasm of pituitary gland; Malignant ACTH Secreting Neoplasm of the Pituitary; malignant ACTH secreting neoplasm of the pituitary; Malignant ACTH Secreting Neoplasm of the Pituitary Gland; malignant ACTH secreting neoplasm of the pituitary gland; Malignant ACTH Secreting Pituitary Gland Tumor; malignant ACTH secreting pituitary gland tumor; malignant ACTH secreting pituitary gland tumour; Malignant ACTH Secreting Pituitary Neoplasm; malignant ACTH secreting pituitary neoplasm; Malignant ACTH Secreting Pituitary Tumor; malignant ACTH secreting pituitary tumor; malignant ACTH secreting pituitary tumour; Malignant ACTH Secreting Tumor of Pituitary; malignant ACTH secreting tumor of pituitary; Malignant ACTH Secreting Tumor of Pituitary Gland; malignant ACTH secreting tumor of pituitary gland; Malignant ACTH Secreting Tumor of the Pituitary; malignant ACTH secreting tumor of the pituitary; Malignant ACTH Secreting Tumor of the Pituitary Gland; malignant ACTH secreting tumor of the pituitary gland; malignant ACTH secreting tumour of pituitary; malignant ACTH secreting tumour of pituitary gland; malignant ACTH secreting tumour of the pituitary; malignant ACTH secreting tumour of the pituitary gland; Malignant Adrenocorticotropin Producing Neoplasm of Pituitary; malignant adrenocorticotropin producing neoplasm of pituitary; Malignant Adrenocorticotropin Producing Neoplasm of Pituitary Gland; malignant adrenocorticotropin producing neoplasm of pituitary gland; Malignant Adrenocorticotropin Producing Neoplasm of the Pituitary; malignant adrenocorticotropin producing neoplasm of the pituitary; Malignant Adrenocorticotropin Producing Neoplasm of the Pituitary Gland; malignant adrenocorticotropin producing neoplasm of the pituitary gland; Malignant Adrenocorticotropin Producing Pituitary Gland Neoplasm; malignant adrenocorticotropin producing pituitary gland neoplasm; Malignant Adrenocorticotropin Producing Pituitary Gland Tumor; malignant adrenocorticotropin producing pituitary gland tumor; malignant adrenocorticotropin producing pituitary gland tumour; Malignant Adrenocorticotropin Producing Pituitary Neoplasm; malignant adrenocorticotropin producing pituitary neoplasm; Malignant Adrenocorticotropin Producing Pituitary Tumor; malignant adrenocorticotropin producing pituitary tumor; malignant adrenocorticotropin producing pituitary tumour; Malignant Adrenocorticotropin Producing Tumor of Pituitary; malignant adrenocorticotropin producing tumor of pituitary; Malignant Adrenocorticotropin Producing Tumor of Pituitary Gland; malignant adrenocorticotropin producing tumor of pituitary gland; Malignant Adrenocorticotropin Producing Tumor of the Pituitary; malignant adrenocorticotropin producing tumor of the pituitary; Malignant Adrenocorticotropin Producing Tumor of the Pituitary Gland; malignant adrenocorticotropin producing tumor of the pituitary gland; malignant adrenocorticotropin producing tumour of pituitary; malignant adrenocorticotropin producing tumour of pituitary gland; malignant adrenocorticotropin producing tumour of the pituitary; malignant adrenocorticotropin producing tumour of the pituitary gland; Malignant Adrenocorticotropin Secreting Pituitary Gland Neoplasm; malignant adrenocorticotropin secreting pituitary gland neoplasm; Malignant Adrenocorticotropin Secreting Pituitary Gland Tumor; malignant adrenocorticotropin secreting pituitary gland tumor; malignant adrenocorticotropin secreting pituitary gland tumour; Malignant Adrenocorticotropin Secreting Pituitary Neoplasm; malignant adrenocorticotropin secreting pituitary neoplasm; Malignant Adrenocorticotropin Secreting Pituitary Tumor; malignant adrenocorticotropin secreting pituitary tumor; malignant adrenocorticotropin secreting pituitary tumour; Malignant Corticotropin Secreting Pituitary Gland Neoplasm; malignant corticotropin secreting pituitary gland neoplasm; Malignant Corticotropinoma of Pituitary; malignant Corticotropinoma of pituitary; Malignant Corticotropinoma of Pituitary Gland; malignant Corticotropinoma of pituitary gland; Malignant Corticotropinoma of the Pituitary; malignant Corticotropinoma of the pituitary; Malignant Corticotropinoma of the Pituitary Gland; malignant Corticotropinoma of the pituitary gland; Malignant Pituitary Corticotropinoma; malignant pituitary Corticotropinoma; Malignant Pituitary Gland Corticotropinoma; malignant pituitary gland Corticotropinoma; Metastatic ACTH-Producing PitNET; Metastatic Corticotroph Pituitary Neuroendocrine Tumor
 
Monarch Initiative: MONDO:0006069

Definition

ACTH-producing pituitary neuroendocrine tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVACTH-producing pituitary gland carcinoma

Professional guidelines

PubMed

Primary adrenal causes of Cushing's syndrome. Diagnosis and surgical management.
Perry RR, Nieman LK, Cutler GB Jr, Chrousos GP, Loriaux DL, Doppman JL, Travis WD, Norton JA
Ann Surg 1989 Jul;210(1):59-68. doi: 10.1097/00000658-198907000-00010. PMID: 2742414Free PMC Article

Recent clinical studies

Etiology

Effects of CAPTEM (Capecitabine and Temozolomide) on a Corticotroph Carcinoma and an Aggressive Corticotroph Tumor.
Nakano-Tateno T, Satou M, Inoshita N, van Landeghem FKH, Easaw J, Mehta V, Tateno T, Chik CL
Endocr Pathol 2021 Sep;32(3):418-426. Epub 2020 Aug 24 doi: 10.1007/s12022-020-09647-w. PMID: 32833164
In vivo imaging of chromogranin A-positive endocrine tumours by three-step monoclonal antibody targeting.
Siccardi AG, Paganelli G, Pontiroli AE, Pelagi M, Magnani P, Viale G, Faglia G, Fazio F
Eur J Nucl Med 1996 Nov;23(11):1455-9. doi: 10.1007/BF01254467. PMID: 8854841
Cushing's syndrome: problems in management.
Aron DC, Findling JW, Fitzgerald PA, Forsham PH, Wilson CB, Tyrrell JB
Endocr Rev 1982 Summer;3(3):229-44. doi: 10.1210/edrv-3-3-229. PMID: 6288366

Diagnosis

Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025
Pituitary carcinoma: a review of the literature.
Ragel BT, Couldwell WT
Neurosurg Focus 2004 Apr 15;16(4):E7. doi: 10.3171/foc.2004.16.4.8. PMID: 15191336
ACTH-producing pituitary cancer: experience at the King Faisal Specialist Hospital & Research Centre.
Ahmed M, Kanaan I, Alarifi A, Ba-Essa E, Saleem M, Tulbah A, McArthur P, Hessler R
Pituitary 2000 Oct;3(2):105-12. doi: 10.1023/a:1009957824871. PMID: 11141693
ACTH-producing pituitary tumors.
Grua JR, Nelson DH
Endocrinol Metab Clin North Am 1991 Jun;20(2):319-62. PMID: 1652434
Cushing's syndrome: problems in management.
Aron DC, Findling JW, Fitzgerald PA, Forsham PH, Wilson CB, Tyrrell JB
Endocr Rev 1982 Summer;3(3):229-44. doi: 10.1210/edrv-3-3-229. PMID: 6288366

Therapy

Effects of CAPTEM (Capecitabine and Temozolomide) on a Corticotroph Carcinoma and an Aggressive Corticotroph Tumor.
Nakano-Tateno T, Satou M, Inoshita N, van Landeghem FKH, Easaw J, Mehta V, Tateno T, Chik CL
Endocr Pathol 2021 Sep;32(3):418-426. Epub 2020 Aug 24 doi: 10.1007/s12022-020-09647-w. PMID: 32833164
Diagnosis and surgical treatment of ectopic adrenocorticotropic hormone-producing pulmonary tumors accompanied by Cushing syndrome.
Sakuraba M, Murasugi M, Oyama K, Adachi T, Ikeda T, Onuki T
Jpn J Thorac Cardiovasc Surg 2003 Dec;51(12):656-9. doi: 10.1007/s11748-003-0004-9. PMID: 14717419
ACTH-producing pituitary cancer: experience at the King Faisal Specialist Hospital & Research Centre.
Ahmed M, Kanaan I, Alarifi A, Ba-Essa E, Saleem M, Tulbah A, McArthur P, Hessler R
Pituitary 2000 Oct;3(2):105-12. doi: 10.1023/a:1009957824871. PMID: 11141693
Pituitary hyperplasia after goserelin (LHRH-analogue) therapy.
Radner H, Pummer K, Lax S, Wandschneider G, Höfler H
Neuropathol Appl Neurobiol 1991 Feb;17(1):75-81. doi: 10.1111/j.1365-2990.1991.tb00696.x. PMID: 1647501
Cushing's syndrome: problems in management.
Aron DC, Findling JW, Fitzgerald PA, Forsham PH, Wilson CB, Tyrrell JB
Endocr Rev 1982 Summer;3(3):229-44. doi: 10.1210/edrv-3-3-229. PMID: 6288366

Prognosis

Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025
A case of corticotroph carcinoma that caused multiple cranial nerve palsies, destructive petrosal bone invasion, and liver metastasis.
Ono M, Miki N, Amano K, Hayashi M, Kawamata T, Seki T, Takano K, Katagiri S, Yamamoto M, Nishikawa T, Kubo O, Sano T, Hori T, Okada Y
Endocr Pathol 2011 Mar;22(1):10-7. doi: 10.1007/s12022-010-9144-5. PMID: 21234708Free PMC Article
ACTH-producing pituitary cancer: experience at the King Faisal Specialist Hospital & Research Centre.
Ahmed M, Kanaan I, Alarifi A, Ba-Essa E, Saleem M, Tulbah A, McArthur P, Hessler R
Pituitary 2000 Oct;3(2):105-12. doi: 10.1023/a:1009957824871. PMID: 11141693

Clinical prediction guides

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Prop-1 gene expression in human pituitary tumors.
Nakamura S, Ohtsuru A, Takamura N, Kitange G, Tokunaga Y, Yasunaga A, Shibata S, Yamashita S
J Clin Endocrinol Metab 1999 Jul;84(7):2581-4. doi: 10.1210/jcem.84.7.5974. PMID: 10404841
Expression of prohormone convertase, PC2, in adrenocorticotropin-producing thymic carcinoid with elevated plasma corticotropin-releasing hormone.
Kimura N, Ishikawa T, Sasaki Y, Sasano N, Onodera K, Shimizu Y, Kimura I, Steiner DF, Nagura H
J Clin Endocrinol Metab 1996 Jan;81(1):390-5. doi: 10.1210/jcem.81.1.8550783. PMID: 8550783
Light and electron microscopic localization of ACTH and pro-opiomelanocortin-derived peptides in human developmental and neoplastic cells.
Osamura RY, Tsutsumi Y, Watanabe K
J Histochem Cytochem 1984 Aug;32(8):885-93. doi: 10.1177/32.8.6086743. PMID: 6086743
Gamma-melanotrophin-like immunoreactivities in human pituitaries, ACTH-producing pituitary adenomas, and ectopic ACTH-producing tumours: evidence for an abnormality in glycosylation in ectopic ACTH-producing tumours.
Tanaka I, Nakai Y, Nakao K, Oki S, Fukata J, Imura H
Clin Endocrinol (Oxf) 1981 Oct;15(4):353-61. doi: 10.1111/j.1365-2265.1981.tb00675.x. PMID: 6274545

Recent systematic reviews

Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025

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