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Malignant cutaneous granular cell skin tumor

MedGen UID:
233658
•Concept ID:
C1334575
•
Neoplastic Process
Synonyms: Cutaneous Malignant Granular Cell Tumor; malignant cutaneous granular cell skin tumor; Malignant Cutaneous Granular Cell Tumor; malignant cutaneous granular cell tumor; malignant cutaneous granular cell tumour; Malignant Granular Cell Neoplasm of Skin; malignant granular cell neoplasm of skin; Malignant Granular Cell Neoplasm of the Skin; malignant granular cell neoplasm of the skin; Malignant Granular Cell Skin Neoplasm; malignant granular cell skin neoplasm; Malignant Granular Cell Skin Tumor; malignant granular cell skin tumor; malignant granular cell skin tumour; Malignant Granular Cell Tumor of Skin; malignant granular cell tumor of skin; Malignant Granular Cell Tumor of the Skin; malignant granular cell tumor of the skin; malignant granular cell tumour of skin; malignant granular cell tumour of the skin
 
Monarch Initiative: MONDO:0004314

Definition

A malignant granular cell tumor that arises from the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant cutaneous granular cell skin tumor

Professional guidelines

PubMed

Newly Diagnosed Sellar Tumors in Patients with Cancer: A Diagnostic Challenge and Management Dilemma.
Goulart CR, Upadhyay S, Ditzel Filho LFS, Beer-Furlan A, Carrau RL, Prevedello LM, Prevedello DM
World Neurosurg 2017 Oct;106:254-265. Epub 2017 Jun 30 doi: 10.1016/j.wneu.2017.06.139. PMID: 28673886
Differential diagnosis of squamous cell carcinoma in situ using skin histopathological images.
Noroozi N, Zakerolhosseini A
Comput Biol Med 2016 Mar 1;70:23-39. Epub 2016 Jan 7 doi: 10.1016/j.compbiomed.2015.12.024. PMID: 26780250
HMB-45 and Melan-A are useful in the differential diagnosis between granular cell tumor and malignant melanoma.
Gleason BC, Nascimento AF
Am J Dermatopathol 2007 Feb;29(1):22-7. doi: 10.1097/01.dad.0000249888.41884.6c. PMID: 17284958

Recent clinical studies

Etiology

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity.
El-Khalawany M, Rageh MA, Hassab-El-Naby HMM
Am J Dermatopathol 2022 Jan 1;44(1):7-16. doi: 10.1097/DAD.0000000000002088. PMID: 34783707
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Granular Cell Tumor: A Clinical Study of 81 Patients.
Marcoval J, Bauer-Alonso A, Llobera-Ris C, Moreno-Vilchez C, Penín RM, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2021 May;112(5):441-446. Epub 2020 Nov 27 doi: 10.1016/j.ad.2020.11.012. PMID: 33253647
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Atypical fibroxanthoma: a selective review.
Gru AA, Santa Cruz DJ
Semin Diagn Pathol 2013 Feb;30(1):4-12. doi: 10.1053/j.semdp.2012.01.001. PMID: 23327726

Diagnosis

The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Fischer GM, Papke DJ Jr
Semin Diagn Pathol 2023 Jul;40(4):246-257. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.014. PMID: 37156707
An update on cutaneous granular cell tumours for dermatologists and dermatopathologists.
Amphlett A
Clin Exp Dermatol 2022 Nov;47(11):1916-1922. Epub 2022 Sep 6 doi: 10.1111/ced.15309. PMID: 35727729
Recent advances in the diagnosis, classification and molecular pathogenesis of cutaneous mesenchymal neoplasms.
Papke DJ Jr, Hornick JL
Histopathology 2022 Jan;80(1):216-232. doi: 10.1111/his.14450. PMID: 34958499
Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity.
El-Khalawany M, Rageh MA, Hassab-El-Naby HMM
Am J Dermatopathol 2022 Jan 1;44(1):7-16. doi: 10.1097/DAD.0000000000002088. PMID: 34783707

Therapy

EBER in situ hybridization in subcutaneous aluminum granulomas/lymphoid hyperplasia: A diagnostic clue to differentiate injection-associated lymphoid hyperplasia from other forms of pseudolymphomas and cutaneous lymphomas.
Frings VG, Roth S, Rosenwald A, Goebeler M, Geissinger E, Wobser M
J Cutan Pathol 2021 May;48(5):625-631. Epub 2021 Feb 11 doi: 10.1111/cup.13972. PMID: 33496022
CD8-positive cutaneous lymphoproliferation associated with large granular lymphocyte leukemia in a patient with X-linked agammaglobulinemia.
Daou H, Hatch LA, Weinkle A, Morey GE, Messina J, Zhang X, Sokol L, Seminario-Vidal L
J Cutan Pathol 2021 Apr;48(4):567-571. Epub 2020 Sep 30 doi: 10.1111/cup.13860. PMID: 32885480
Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma.
Frankel AE, Woo JH, Ahn C, Foss FM, Duvic M, Neville PH, Neville DM
Haematologica 2015 Jun;100(6):794-800. Epub 2015 Mar 20 doi: 10.3324/haematol.2015.123711. PMID: 25795722Free PMC Article
Periocular cutaneous oncocytoma with signs of disrupted oxygen metabolism.
Wobser M, Haferkamp S, Roth S, Meyer-Ter-Vehn T, Pfister A, Giner T, Rütten A, Kneitz H, Goebeler M, Geissinger E
J Cutan Pathol 2013 Dec;40(12):1054-8. Epub 2013 Sep 20 doi: 10.1111/cup.12223. PMID: 24111916
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.
Sarangarajan R, Budev A, Zhao Y, Gahl WA, Boissy RE
J Invest Dermatol 2001 Sep;117(3):641-6. doi: 10.1046/j.0022-202x.2001.01435.x. PMID: 11564171

Prognosis

An update on cutaneous granular cell tumours for dermatologists and dermatopathologists.
Amphlett A
Clin Exp Dermatol 2022 Nov;47(11):1916-1922. Epub 2022 Sep 6 doi: 10.1111/ced.15309. PMID: 35727729
Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database.
Mirza FN, Tuggle CT, Zogg CK, Mirza HN, Narayan D
J Am Acad Dermatol 2018 Mar;78(3):490-497.e1. Epub 2017 Oct 5 doi: 10.1016/j.jaad.2017.09.062. PMID: 28989104Free PMC Article
Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature.
Pérez-González YC, Pagura L, Llamas-Velasco M, Cortes-Lambea L, Kutzner H, Requena L
Am J Dermatopathol 2015 Apr;37(4):334-40. doi: 10.1097/DAD.0000000000000106. PMID: 25794371
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
PEComas: a review with emphasis on cutaneous lesions.
Walsh SN, Sangüeza OP
Semin Diagn Pathol 2009 Aug;26(3):123-30. doi: 10.1053/j.semdp.2009.09.002. PMID: 20043511

Clinical prediction guides

Expression of Melan-A in cutaneous granular cell tumours: a diagnostic pitfall.
Van Winden VI, Wong DD, Wood BA, Filion P, Harvey NT
Pathology 2024 Feb;56(1):47-51. Epub 2023 Nov 1 doi: 10.1016/j.pathol.2023.09.009. PMID: 37989630
Measurement of Tumor Thickness in Cutaneous Squamous Cell Carcinomas: Do the Different Methods Provide Better Prognostic Data?
Yildiz P, Aung PP, Milton DR, Hruska C, Ivan D, Nagarajan P, Tetzlaff MT, Curry JL, Torres-Cabala C, Prieto VG
Am J Dermatopathol 2020 May;42(5):337-342. doi: 10.1097/DAD.0000000000001511. PMID: 31464719
Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature.
Pérez-González YC, Pagura L, Llamas-Velasco M, Cortes-Lambea L, Kutzner H, Requena L
Am J Dermatopathol 2015 Apr;37(4):334-40. doi: 10.1097/DAD.0000000000000106. PMID: 25794371
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

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