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Malignant gastric granular cell tumor

MedGen UID:
233664
•Concept ID:
C1334585
•
Neoplastic Process
Synonyms: Malignant Gastric Granular Cell Neoplasm; malignant gastric granular cell neoplasm; Malignant Gastric Granular Cell Tumor; malignant gastric granular cell tumor; Malignant Granular Cell Neoplasm of Stomach; malignant granular cell neoplasm of stomach; Malignant Granular Cell Neoplasm of the Stomach; malignant granular cell neoplasm of the stomach; Malignant Granular Cell Stomach Neoplasm; malignant granular cell stomach neoplasm; Malignant Granular Cell Stomach Tumor; malignant granular cell stomach tumor; malignant granular cell stomach tumour; Malignant Granular Cell Tumor of Stomach; malignant granular cell tumor of stomach; Malignant Granular Cell Tumor of the Stomach; malignant granular cell tumor of the stomach; malignant granular cell tumour of stomach; malignant granular cell tumour of the stomach
 
Monarch Initiative: MONDO:0001057

Definition

A metastasizing granular cell tumor that arises from the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant gastric granular cell tumor

Professional guidelines

PubMed

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797

Recent clinical studies

Etiology

Underwater endoscopic mucosal resection of upper gastrointestinal subepithelial tumors: A case series pilot study (with video).
Kim SJ, Kim TU, Choi CW, Kim HW, Park SB, Ryu DG
Medicine (Baltimore) 2022 Oct 14;101(41):e31072. doi: 10.1097/MD.0000000000031072. PMID: 36254017Free PMC Article
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
GP73 is down-regulated in gastric cancer and associated with tumor differentiation.
Chen LG, Wang HJ, Yao HB, Guan TP, Wu F, He XJ, Ma YY, Tao HQ, Ye ZY
World J Surg Oncol 2013 Jun 7;11:132. doi: 10.1186/1477-7819-11-132. PMID: 23742050Free PMC Article
Four cases of patients with gastrointestinal granular cell tumors.
Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U
South Med J 2007 Mar;100(3):298-300. doi: 10.1097/SMJ.0b013e318030eeff. PMID: 17396735
Leiomyoma of the oral cavity: a light microscopic and immunohistochemical study with review of the literature from 1884 to 1992.
Baden E, Doyle JL, Lederman DA
Eur J Cancer B Oral Oncol 1994 Jan;30B(1):1-7. doi: 10.1016/0964-1955(94)90043-4. PMID: 9135966

Diagnosis

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital.
Jobrack AD, Goel S, Cotlar AM
Mil Med 2018 Sep 1;183(9-10):e589-e593. doi: 10.1093/milmed/usx237. PMID: 29548015
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation.
Lewis RB, Mehrotra AK, Rodriguez P, Levine MS
Radiographics 2013 Jul-Aug;33(4):1083-108. doi: 10.1148/rg.334135027. PMID: 23842973
Selected unusual tumors of the stomach: a review.
Wang LM, Chetty R
Int J Surg Pathol 2012 Feb;20(1):5-14. Epub 2011 Nov 30 doi: 10.1177/1066896911429300. PMID: 22134628

Therapy

Over-the-scope clip-assisted method for resection of full-thickness submucosal lesions of the gastrointestinal tract.
Sarker S, Gutierrez JP, Council L, Brazelton JD, Kyanam Kabir Baig KR, Mönkemüller K
Endoscopy 2014 Sep;46(9):758-61. Epub 2014 May 15 doi: 10.1055/s-0034-1365513. PMID: 24830398
Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video).
Li QL, Yao LQ, Zhou PH, Xu MD, Chen SY, Zhong YS, Zhang YQ, Chen WF, Ma LL, Qin WZ
Gastrointest Endosc 2012 Jun;75(6):1153-8. Epub 2012 Mar 28 doi: 10.1016/j.gie.2012.01.037. PMID: 22459663
Preliminary studies on anti-tumor activity of 2',4'-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells.
Lou C, Wang M, Yang G, Cai H, Li Y, Zhao F, Yang H, Tong L, Cai B
Toxicol In Vitro 2009 Aug;23(5):906-10. Epub 2009 May 18 doi: 10.1016/j.tiv.2009.05.002. PMID: 19457454
Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness.
Kuniyasu T, Nakamura T, Tabuchi Y, Kuroda Y
Cancer 1998 Oct 1;83(7):1300-6. doi: 10.1002/(sici)1097-0142(19981001)83:7<1300::aid-cncr5>3.0.co;2-m. PMID: 9762929
Regression of superficial gastric MALT lymphoma with unsuccessful eradication therapy for Helicobacter pylori infection.
Yoshikane H, Yokoi T, Hidano H, Sakakibara A, Niwa Y, Goto H
J Gastroenterol 1997 Dec;32(6):812-6. doi: 10.1007/BF02936960. PMID: 9430022

Prognosis

Recent developments in gastroesophageal mesenchymal tumours.
Papke DJ Jr, Hornick JL
Histopathology 2021 Jan;78(1):171-186. doi: 10.1111/his.14164. PMID: 33382494
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital.
Jobrack AD, Goel S, Cotlar AM
Mil Med 2018 Sep 1;183(9-10):e589-e593. doi: 10.1093/milmed/usx237. PMID: 29548015
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
GP73 is down-regulated in gastric cancer and associated with tumor differentiation.
Chen LG, Wang HJ, Yao HB, Guan TP, Wu F, He XJ, Ma YY, Tao HQ, Ye ZY
World J Surg Oncol 2013 Jun 7;11:132. doi: 10.1186/1477-7819-11-132. PMID: 23742050Free PMC Article
Granular cell tumors.
Morrison JG, Gray GF Jr, Dao AH, Adkins RB Jr
Am Surg 1987 Mar;53(3):156-60. PMID: 3030172

Clinical prediction guides

Underwater endoscopic mucosal resection of upper gastrointestinal subepithelial tumors: A case series pilot study (with video).
Kim SJ, Kim TU, Choi CW, Kim HW, Park SB, Ryu DG
Medicine (Baltimore) 2022 Oct 14;101(41):e31072. doi: 10.1097/MD.0000000000031072. PMID: 36254017Free PMC Article
Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases.
An S, Jang J, Min K, Kim MS, Park H, Park YS, Kim J, Lee JH, Song HJ, Kim KJ, Yu E, Hong SM
Hum Pathol 2015 Jun;46(6):813-9. Epub 2015 Feb 26 doi: 10.1016/j.humpath.2015.02.005. PMID: 25882927
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Primary advanced gastric small cell carcinoma: a case report and review of the literature.
Takaku H, Oka K, Naoi Y, Santoh N, Setsu Y, Mori N
Am J Gastroenterol 1999 May;94(5):1402-4. doi: 10.1111/j.1572-0241.1999.01095.x. PMID: 10235227
Combined granular cell tumour of the oesophagus and stomach: a case report and review of the literature.
Blandamura S, Altavilla G, Castoro C, Antonini C, Piazza M
Ital J Gastroenterol 1993 Jun;25(5):259-64. PMID: 8353300

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