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Mediastinal germ cell tumor

MedGen UID:
233678
•Concept ID:
C1334655
•
Neoplastic Process
Synonyms: Germ Cell Neoplasm of Mediastinum; germ cell neoplasm of mediastinum; Germ Cell Neoplasm of the Mediastinum; germ cell neoplasm of the mediastinum; Germ Cell Tumor of Mediastinum; germ cell tumor of mediastinum; Germ Cell Tumor of the Mediastinum; germ cell tumor of the mediastinum; germ cell tumour of mediastinum; germ cell tumour of the mediastinum; Mediastinal Germ Cell Neoplasm; mediastinal germ cell neoplasm; Mediastinal Germ Cell Tumor; mediastinal germ cell tumor; mediastinum germ cell tumor; mediastinum germ cell tumour; Thymic Germ Cell Tumor; thymic germ cell tumor; thymic germ cell tumour
 
Monarch Initiative: MONDO:0021067

Definition

A germ cell tumor that arises from the mediastinum. Representative examples include seminoma, embryonal carcinoma, yolk sac tumor, teratoma, and mixed germ cell tumor. [from NCI]

Professional guidelines

PubMed

Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults.
Biswas B, Dabkara D, Sengupta M, Ganguly S, Ghosh J, Arunsingh S M, Sen S
Cancer Rep (Hoboken) 2021 Feb;4(1):e1306. Epub 2020 Oct 8 doi: 10.1002/cnr2.1306. PMID: 33029924Free PMC Article
Management of the primary malignant mediastinal germ cell tumors: experience with 54 patients.
Liu Y, Wang Z, Peng ZM, Yu Y
Diagn Pathol 2014 Feb 19;9:33. doi: 10.1186/1746-1596-9-33. PMID: 24552239Free PMC Article
Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum.
Liu TZ, Zhang DS, Liang Y, Zhou NN, Gao HF, Liu KJ, Wu HY
J Cancer Res Clin Oncol 2011 Nov;137(11):1607-12. Epub 2011 Aug 18 doi: 10.1007/s00432-011-1028-7. PMID: 21850383Free PMC Article

Recent clinical studies

Etiology

Assessment of Resectability of Mediastinal Germ Cell Tumor Using Preoperative Computed Tomography.
Kawakubo N, Okubo Y, Yotsukura M, Yoshida Y, Nakagawa K, Yonemori K, Watanabe H, Yatabe Y, Watanabe SI
J Surg Res 2022 Apr;272:61-68. Epub 2021 Dec 20 doi: 10.1016/j.jss.2021.11.002. PMID: 34936913
Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults.
Biswas B, Dabkara D, Sengupta M, Ganguly S, Ghosh J, Arunsingh S M, Sen S
Cancer Rep (Hoboken) 2021 Feb;4(1):e1306. Epub 2020 Oct 8 doi: 10.1002/cnr2.1306. PMID: 33029924Free PMC Article
Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience.
Sachdeva AK, Penumadu P, Kohli P, Dubashi B, Munuswamy H
Asian Cardiovasc Thorac Ann 2019 Feb;27(2):98-104. Epub 2019 Jan 15 doi: 10.1177/0218492318823345. PMID: 30646758
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Mediastinal germ cell tumors: clinical aspects and outcomes in 7 children.
De Backer A, Madern GC, Hakvoort-Cammel FG, Oosterhuis JW, Hazebroek FW
Eur J Pediatr Surg 2006 Oct;16(5):318-22. doi: 10.1055/s-2006-924647. PMID: 17160775

Diagnosis

Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature.
Matsumoto NP, Yuan J, Wang J, Shen Q, Chen X, Kim Y, Zuppan CW, Chang CC, Cui W, Chen D, Shi M, Gisriel SD, Chen M, Xu ML, Pan Z
Mod Pathol 2022 Jul;35(7):865-874. Epub 2022 Feb 1 doi: 10.1038/s41379-022-01014-w. PMID: 35105959
Primary Mediastinal Germ Cell Tumors-The University of Western Ontario Experience.
Lavi A, Winquist E, Nair SM, Chin JL, Izawa J, Fernandes R, Ernst S, Power NE
Curr Oncol 2020 Dec 8;28(1):78-85. doi: 10.3390/curroncol28010010. PMID: 33704177Free PMC Article
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Acute Leukemia and Concurrent Mediastinal Germ Cell Tumor: Case Report and Literature Review.
Maese L, Li KD, Xu X, Afify Z, Paxton CN, Putnam A
Fetal Pediatr Pathol 2017 Apr;36(2):168-176. Epub 2017 Jan 19 doi: 10.1080/15513815.2016.1273983. PMID: 28103116
Diagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinoma.
Hainsworth JD
Chest Surg Clin N Am 2002 Nov;12(4):665-72. doi: 10.1016/s1052-3359(02)00031-5. PMID: 12471870

Therapy

A primary mediastinal germ cell tumor of yolk sac type: case report.
Darif K, Benbrahim Z, Acharfi N, Khacha A, Maaroufi M, Amaadour L, Oualla K, Arifi S, Mellas N
Pan Afr Med J 2021;38:330. Epub 2021 Apr 6 doi: 10.11604/pamj.2021.38.330.23730. PMID: 34285753Free PMC Article
Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults.
Biswas B, Dabkara D, Sengupta M, Ganguly S, Ghosh J, Arunsingh S M, Sen S
Cancer Rep (Hoboken) 2021 Feb;4(1):e1306. Epub 2020 Oct 8 doi: 10.1002/cnr2.1306. PMID: 33029924Free PMC Article
Incidentally discovered primary mediastinal germ cell tumor.
Wong V, Geynisman DM
JAAPA 2020 Apr;33(4):35-37. doi: 10.1097/01.JAA.0000657172.30545.a3. PMID: 32217905Free PMC Article
Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience.
Sachdeva AK, Penumadu P, Kohli P, Dubashi B, Munuswamy H
Asian Cardiovasc Thorac Ann 2019 Feb;27(2):98-104. Epub 2019 Jan 15 doi: 10.1177/0218492318823345. PMID: 30646758
Extraskeletal osteosarcoma of the mediastinum after treatment of a mediastinal germ-cell tumor.
Ulusakarya A, Terrier P, Regnard JF, de Montpreville V, Munck JN
Am J Clin Oncol 1999 Dec;22(6):609-14. doi: 10.1097/00000421-199912000-00013. PMID: 10597747

Prognosis

Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature.
Matsumoto NP, Yuan J, Wang J, Shen Q, Chen X, Kim Y, Zuppan CW, Chang CC, Cui W, Chen D, Shi M, Gisriel SD, Chen M, Xu ML, Pan Z
Mod Pathol 2022 Jul;35(7):865-874. Epub 2022 Feb 1 doi: 10.1038/s41379-022-01014-w. PMID: 35105959
Assessment of Resectability of Mediastinal Germ Cell Tumor Using Preoperative Computed Tomography.
Kawakubo N, Okubo Y, Yotsukura M, Yoshida Y, Nakagawa K, Yonemori K, Watanabe H, Yatabe Y, Watanabe SI
J Surg Res 2022 Apr;272:61-68. Epub 2021 Dec 20 doi: 10.1016/j.jss.2021.11.002. PMID: 34936913
Primary Mediastinal Germ Cell Tumors-The University of Western Ontario Experience.
Lavi A, Winquist E, Nair SM, Chin JL, Izawa J, Fernandes R, Ernst S, Power NE
Curr Oncol 2020 Dec 8;28(1):78-85. doi: 10.3390/curroncol28010010. PMID: 33704177Free PMC Article
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Acute Leukemia and Concurrent Mediastinal Germ Cell Tumor: Case Report and Literature Review.
Maese L, Li KD, Xu X, Afify Z, Paxton CN, Putnam A
Fetal Pediatr Pathol 2017 Apr;36(2):168-176. Epub 2017 Jan 19 doi: 10.1080/15513815.2016.1273983. PMID: 28103116

Clinical prediction guides

Assessment of Resectability of Mediastinal Germ Cell Tumor Using Preoperative Computed Tomography.
Kawakubo N, Okubo Y, Yotsukura M, Yoshida Y, Nakagawa K, Yonemori K, Watanabe H, Yatabe Y, Watanabe SI
J Surg Res 2022 Apr;272:61-68. Epub 2021 Dec 20 doi: 10.1016/j.jss.2021.11.002. PMID: 34936913
Thoracoscopic Resection of a Nonseminomatous Primary Mediastinal Germ Cell Tumor.
Caso R, Marshall MB
Semin Thorac Cardiovasc Surg 2019 Winter;31(4):870-872. Epub 2019 Apr 11 doi: 10.1053/j.semtcvs.2019.04.004. PMID: 30981738
Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum.
Liu TZ, Zhang DS, Liang Y, Zhou NN, Gao HF, Liu KJ, Wu HY
J Cancer Res Clin Oncol 2011 Nov;137(11):1607-12. Epub 2011 Aug 18 doi: 10.1007/s00432-011-1028-7. PMID: 21850383Free PMC Article
Mediastinal germ cell tumors: clinical aspects and outcomes in 7 children.
De Backer A, Madern GC, Hakvoort-Cammel FG, Oosterhuis JW, Hazebroek FW
Eur J Pediatr Surg 2006 Oct;16(5):318-22. doi: 10.1055/s-2006-924647. PMID: 17160775
Hematologic neoplasia associated with primary mediastinal germ-cell tumors.
Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G
N Engl J Med 1990 May 17;322(20):1425-9. doi: 10.1056/NEJM199005173222004. PMID: 2158625

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