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Mixed germ cell tumor of central nervous system

MedGen UID:
233713
•Concept ID:
C1334785
•
Neoplastic Process
Synonyms: Central Nervous System Mixed Germ Cell Tumor; central nervous system mixed germ cell tumor; central nervous system mixed germ cell tumour; CNS Mixed Germ Cell Tumor; CNS mixed germ cell tumor; CNS mixed germ cell tumour; Mixed germ cell neoplasm of central nervous system; Mixed Germ Cell Neoplasm of the Central Nervous System; mixed germ cell neoplasm of the central nervous system; mixed germ cell tumor of central nervous system; Mixed Germ Cell Tumor of CNS; Mixed germ cell tumor of CNS; mixed germ cell tumor of CNS; Mixed Germ Cell Tumor of the Central Nervous System; mixed germ cell tumor of the central nervous system; Mixed Germ Cell Tumor of the CNS; mixed germ cell tumor of the CNS; mixed germ cell tumour of CNS; mixed germ cell tumour of the central nervous system; mixed germ cell tumour of the CNS
SNOMED CT: Mixed germ cell neoplasm of central nervous system (866050001)
 
Monarch Initiative: MONDO:0016742
Orphanet: ORPHA252021

Definition

A malignant germ cell tumor of the central nervous system characterized by the presence of at least two types of germ cell neoplasia. [from NCI]

Professional guidelines

PubMed

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Diaph3 underlines tumor cell heterogeneity in glioblastoma with implications for treatment modalities resistance.
Stoyanov GS, Lyutfi E, Georgieva R, Georgiev R, Dzhenkov D, Petkova L, Ivanov BD, Kaprelyan A, Ghenev P
J Neurooncol 2022 May;157(3):523-531. Epub 2022 Apr 5 doi: 10.1007/s11060-022-03996-8. PMID: 35380294
Critical review of the management of primary central nervous nongerminomatous germ cell tumors.
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Recent clinical studies

Etiology

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Gliomas in Children.
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Diagnosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Low-grade developmental and epilepsy associated brain tumors: a critical update 2020.
Slegers RJ, Blumcke I
Acta Neuropathol Commun 2020 Mar 9;8(1):27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273Free PMC Article
Gliomas in Children.
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Therapy

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Re-induction chemotherapy regimens in patients with recurrent central nervous system mixed malignant germ cell tumors.
Abu Arja MH, Stanek JR, Finlay JL, AbdelBaki MS
Childs Nerv Syst 2018 Nov;34(11):2179-2186. Epub 2018 Aug 3 doi: 10.1007/s00381-018-3940-5. PMID: 30076436
Predictors of clinical outcome in pediatric oligodendroglioma: meta-analysis of individual patient data and multiple imputation.
Wang KY, Vankov ER, Lin DDM
J Neurosurg Pediatr 2018 Feb;21(2):153-163. Epub 2017 Dec 1 doi: 10.3171/2017.7.PEDS17133. PMID: 29192869
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB; EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council
Lancet 2005 Sep 17-23;366(9490):985-90. doi: 10.1016/S0140-6736(05)67070-5. PMID: 16168780
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Gliomas in Children.
Filbin MG, Sturm D
Semin Neurol 2018 Feb;38(1):121-130. Epub 2018 Mar 16 doi: 10.1055/s-0038-1635106. PMID: 29548059
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Clinical prediction guides

Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Predictors of clinical outcome in pediatric oligodendroglioma: meta-analysis of individual patient data and multiple imputation.
Wang KY, Vankov ER, Lin DDM
J Neurosurg Pediatr 2018 Feb;21(2):153-163. Epub 2017 Dec 1 doi: 10.3171/2017.7.PEDS17133. PMID: 29192869
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Recent systematic reviews

Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.
Lampros MG, Vlachos N, Voulgaris S, Alexiou GA
Childs Nerv Syst 2021 Aug;37(8):2465-2474. Epub 2021 Jun 17 doi: 10.1007/s00381-021-05257-x. PMID: 34137942
Space-time clustering of childhood cancers: a systematic review and pooled analysis.
Kreis C, Doessegger E, Lupatsch JE, Spycher BD
Eur J Epidemiol 2019 Jan;34(1):9-21. Epub 2018 Nov 16 doi: 10.1007/s10654-018-0456-y. PMID: 30446850Free PMC Article
Synchronous Tumors of the Cerebellopontine Angle.
Graffeo CS, Perry A, Copeland WR 3rd, Giannini C, Neff BA, Driscoll CL, Link MJ
World Neurosurg 2017 Feb;98:632-643. Epub 2016 Nov 12 doi: 10.1016/j.wneu.2016.11.002. PMID: 27836701

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