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Nodular lymphocyte predominant Hodgkin lymphoma

MedGen UID:
233758
•Concept ID:
C1334968
•
Neoplastic Process
Synonyms: Nodular Lymphocyte Predominant Hodgkin's Lymphoma; Nodular Lymphocyte-Predominant Hodgkin's Lymphoma; Nodular Sclerosing Hodgkin's Lymphoma
SNOMED CT: Hodgkin's disease, lymphocytic predominance, nodular (70600005); Hodgkin lymphoma, lymphocyte predominance, nodular (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (clinical) (118605002); Hodgkin lymphoma, nodular lymphocyte predominance (118605002)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0044778
Orphanet: ORPHA86893

Definition

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL; see this term) characterized histologically by malignant lymphocyte predominant (LP) cells and the absence of typical Hodgkin and Reed-Sternberg (HRS) cells. [from ORDO]

Professional guidelines

PubMed

Hodgkin Lymphoma and Its Differential Diagnosis: New Twists on an Old Challenge.
Sohani AR
Surg Pathol Clin 2023 Jun;16(2):287-346. Epub 2023 Mar 30 doi: 10.1016/j.path.2023.02.002. PMID: 37149361
Current treatment options for nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Recent clinical studies

Etiology

Current treatment options for nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Nodular lymphocyte-predominant Hodgkin lymphoma.
Savage KJ, Mottok A, Fanale M
Semin Hematol 2016 Jul;53(3):190-202. Epub 2016 May 13 doi: 10.1053/j.seminhematol.2016.05.009. PMID: 27496311
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Diagnosis

Molecular biology of Hodgkin lymphoma.
Weniger MA, Küppers R
Leukemia 2021 Apr;35(4):968-981. Epub 2021 Mar 8 doi: 10.1038/s41375-021-01204-6. PMID: 33686198Free PMC Article
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Diagnosis of Hodgkin lymphoma in the modern era.
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Therapy

Current treatment options for nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
Modern principles in the management of nodular lymphocyte-predominant Hodgkin lymphoma.
Spinner MA, Varma G, Advani RH
Br J Haematol 2019 Jan;184(1):17-29. Epub 2018 Nov 28 doi: 10.1111/bjh.15616. PMID: 30485408
Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management.
Eichenauer DA, Engert A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):324-328. doi: 10.1182/asheducation-2017.1.324. PMID: 29222274Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Modern management of lymphocyte-predominant Hodgkin lymphoma.
Xing KH, Savage KJ
Br J Haematol 2013 May;161(3):316-29. Epub 2013 Feb 8 doi: 10.1111/bjh.12244. PMID: 23398605

Prognosis

Lymphocyte predominant Hodgkin lymphoma, antigen-driven after all?
Poppema S
J Pathol 2021 Jan;253(1):1-10. Epub 2020 Nov 18 doi: 10.1002/path.5567. PMID: 33044742
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Diagnosis of Hodgkin lymphoma in the modern era.
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Clinical prediction guides

The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology.
Hartmann S, Dojcinov S, Dotlic S, Gibson SE, Hsi ED, Klapper W, Klimkowska M, Pinilla SMR, Richter J, Sabattini E, Tousseyn T, de Jong D
Virchows Arch 2023 Oct;483(4):451-463. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03554-1. PMID: 37530790Free PMC Article
B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L, Fadle N, Regitz E, Roth S, Cetin O, Kos IA, Hess SM, Bein J, Bohle RM, Vornanen M, Sundström C, De Leval L, Tiacci E, Borchmann P, Engert A, Poeschel V, Held G, Schwarz EC, Neumann F, Preuss KD, Hoth M, Küppers R, Lehman K, Hansmann ML, Becker SL, Bewarder M, Hartmann S
Haematologica 2023 Dec 1;108(12):3347-3358. doi: 10.3324/haematol.2023.282698. PMID: 37139600Free PMC Article
Individualized patient care in nodular lymphocyte-predominant Hodgkin lymphoma.
Borchmann S
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):717-722. doi: 10.1182/hematology.2022000364. PMID: 36485084Free PMC Article
Antibodies and antibody-drug conjugates in the treatment of Hodgkin lymphoma.
Eichenauer DA, Engert A
Eur J Haematol 2014 Jul;93(1):1-8. Epub 2014 May 9 doi: 10.1111/ejh.12347. PMID: 24750367
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

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