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Nodular lymphocyte predominant Hodgkin lymphoma

MedGen UID:
233758
•Concept ID:
C1334968
•
Neoplastic Process
Synonyms: Nodular Lymphocyte Predominant Hodgkin's Lymphoma; Nodular Lymphocyte-Predominant Hodgkin's Lymphoma; Nodular Sclerosing Hodgkin's Lymphoma
SNOMED CT: Hodgkin's disease, lymphocytic predominance, nodular (70600005); Hodgkin lymphoma, lymphocyte predominance, nodular (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (clinical) (118605002); Hodgkin lymphoma, nodular lymphocyte predominance (118605002)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0044778
Orphanet: ORPHA86893

Definition

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL; see this term) characterized histologically by malignant lymphocyte predominant (LP) cells and the absence of typical Hodgkin and Reed-Sternberg (HRS) cells. [from ORDO]

Professional guidelines

PubMed

Current treatment options for nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management.
Eichenauer DA, Engert A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):324-328. doi: 10.1182/asheducation-2017.1.324. PMID: 29222274Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Recent clinical studies

Etiology

How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma.
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Nodular lymphocyte-predominant Hodgkin lymphoma.
Savage KJ, Mottok A, Fanale M
Semin Hematol 2016 Jul;53(3):190-202. Epub 2016 May 13 doi: 10.1053/j.seminhematol.2016.05.009. PMID: 27496311
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Diagnosis

Evolution in the definition and diagnosis of the Hodgkin lymphomas and related entities.
Tousseyn TA, King RL, Fend F, Feldman AL, Brousset P, Jaffe ES
Virchows Arch 2023 Jan;482(1):207-226. Epub 2022 Oct 24 doi: 10.1007/s00428-022-03427-z. PMID: 36274093
Molecular biology of Hodgkin lymphoma.
Weniger MA, Küppers R
Leukemia 2021 Apr;35(4):968-981. Epub 2021 Mar 8 doi: 10.1038/s41375-021-01204-6. PMID: 33686198Free PMC Article
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Diagnosis of Hodgkin lymphoma in the modern era.
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Therapy

Variant histology of pediatric nodular lymphocyte-predominant Hodgkin lymphoma with IgD and CD30 expression.
Ali N, Moussa E, Khorshed E, Zaghloul MS, Elnashar A, Abdalla A
Pediatr Blood Cancer 2023 Nov;70(11):e30647. Epub 2023 Aug 28 doi: 10.1002/pbc.30647. PMID: 37638819
Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Review of Current Literature and Case Discussion.
Sidda A, Naleid NK, Manu G, Graffeo V, Jamil MO
J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221111767. doi: 10.1177/23247096221111767. PMID: 35861500Free PMC Article
How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management.
Eichenauer DA, Engert A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):324-328. doi: 10.1182/asheducation-2017.1.324. PMID: 29222274Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Prognosis

How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma.
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Diagnosis of Hodgkin lymphoma in the modern era.
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Hodgkin Lymphoma: Diagnosis and Treatment.
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Clinical prediction guides

Individualized patient care in nodular lymphocyte-predominant Hodgkin lymphoma.
Borchmann S
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):717-722. doi: 10.1182/hematology.2022000364. PMID: 36485084Free PMC Article
Nodular lymphocyte predominant Hodgkin lymphoma: Experience of Polish Pediatric Leukemia/Lymphoma Study Group.
Klekawka T, Balwierz W, Brozyna A, Chaber R, Dadela-Urbanek A, Koltan A, Kwasnicka J, Mitura-Lesiuk M, Muszynska-Roslan K, Przybyszewski B, Ruranska I, Smalisz K, Mizia-Malarz A, Stachowicz-Stencel T, Stolarska M, Wziatek A, Zielezinska K, Skoczen S
Pediatr Hematol Oncol 2021 Oct;38(7):609-619. Epub 2021 Mar 18 doi: 10.1080/08880018.2021.1894278. PMID: 33734010
Antibodies and antibody-drug conjugates in the treatment of Hodgkin lymphoma.
Eichenauer DA, Engert A
Eur J Haematol 2014 Jul;93(1):1-8. Epub 2014 May 9 doi: 10.1111/ejh.12347. PMID: 24750367
The unique entity of nodular lymphocyte-predominant Hodgkin lymphoma: current approaches to diagnosis and management.
Hawkes EA, Wotherspoon A, Cunningham D
Leuk Lymphoma 2012 Mar;53(3):354-61. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.608455. PMID: 21812538
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

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