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Nodular lymphocyte predominant Hodgkin lymphoma

MedGen UID:
233758
Concept ID:
C1334968
Neoplastic Process
Synonyms: Nodular Lymphocyte Predominant Hodgkin's Lymphoma; Nodular Lymphocyte-Predominant Hodgkin's Lymphoma; Nodular Sclerosing Hodgkin's Lymphoma
SNOMED CT: Hodgkin's disease, lymphocytic predominance, nodular (70600005); Hodgkin lymphoma, lymphocyte predominance, nodular (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (clinical) (118605002); Hodgkin lymphoma, nodular lymphocyte predominance (118605002)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0044778
Orphanet: ORPHA86893

Definition

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL; see this term) characterized histologically by malignant lymphocyte predominant (LP) cells and the absence of typical Hodgkin and Reed-Sternberg (HRS) cells. [from ORDO]

Professional guidelines

PubMed

Eichenauer DA, Hartmann S
Expert Rev Hematol 2023 Jul-Dec;16(8):607-615. Epub 2023 Jun 20 doi: 10.1080/17474086.2023.2226859. PMID: 37337881
Sohani AR
Surg Pathol Clin 2023 Jun;16(2):287-346. Epub 2023 Mar 30 doi: 10.1016/j.path.2023.02.002. PMID: 37149361
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024

Recent clinical studies

Etiology

Eichenauer DA, Hartmann S
Expert Rev Hematol 2023 Jul-Dec;16(8):607-615. Epub 2023 Jun 20 doi: 10.1080/17474086.2023.2226859. PMID: 37337881
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Savage KJ, Mottok A, Fanale M
Semin Hematol 2016 Jul;53(3):190-202. Epub 2016 May 13 doi: 10.1053/j.seminhematol.2016.05.009. PMID: 27496311
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Diagnosis

Weniger MA, Küppers R
Leukemia 2021 Apr;35(4):968-981. Epub 2021 Mar 8 doi: 10.1038/s41375-021-01204-6. PMID: 33686198Free PMC Article
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Therapy

Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
Spinner MA, Varma G, Advani RH
Br J Haematol 2019 Jan;184(1):17-29. Epub 2018 Nov 28 doi: 10.1111/bjh.15616. PMID: 30485408
Eichenauer DA, Engert A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):324-328. doi: 10.1182/asheducation-2017.1.324. PMID: 29222274Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Xing KH, Savage KJ
Br J Haematol 2013 May;161(3):316-29. Epub 2013 Feb 8 doi: 10.1111/bjh.12244. PMID: 23398605

Prognosis

Xia D, Sayed S, Moloo Z, Gakinya SM, Mutuiri A, Wawire J, Okiro P, Courville EL, Hasserjian RP, Sohani AR
Am J Clin Pathol 2022 Feb 3;157(2):231-243. doi: 10.1093/ajcp/aqab113. PMID: 34542569
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Clinical prediction guides

Hartmann S, Dojcinov S, Dotlic S, Gibson SE, Hsi ED, Klapper W, Klimkowska M, Pinilla SMR, Richter J, Sabattini E, Tousseyn T, de Jong D
Virchows Arch 2023 Oct;483(4):451-463. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03554-1. PMID: 37530790Free PMC Article
Thurner L, Fadle N, Regitz E, Roth S, Cetin O, Kos IA, Hess SM, Bein J, Bohle RM, Vornanen M, Sundström C, De Leval L, Tiacci E, Borchmann P, Engert A, Poeschel V, Held G, Schwarz EC, Neumann F, Preuss KD, Hoth M, Küppers R, Lehman K, Hansmann ML, Becker SL, Bewarder M, Hartmann S
Haematologica 2023 Dec 1;108(12):3347-3358. doi: 10.3324/haematol.2023.282698. PMID: 37139600Free PMC Article
Borchmann S
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):717-722. doi: 10.1182/hematology.2022000364. PMID: 36485084Free PMC Article
Klekawka T, Balwierz W, Brozyna A, Chaber R, Dadela-Urbanek A, Koltan A, Kwasnicka J, Mitura-Lesiuk M, Muszynska-Roslan K, Przybyszewski B, Ruranska I, Smalisz K, Mizia-Malarz A, Stachowicz-Stencel T, Stolarska M, Wziatek A, Zielezinska K, Skoczen S
Pediatr Hematol Oncol 2021 Oct;38(7):609-619. Epub 2021 Mar 18 doi: 10.1080/08880018.2021.1894278. PMID: 33734010
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024

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