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Non-Neoplastic Adrenal Gland Disorder

MedGen UID:: 233768
•Concept ID:: C1334993
•: Disease or Syndrome

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNon-Neoplastic Adrenal Gland Disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of endocrine system
        Disorder of adrenal gland
        Non-Neoplastic Adrenal Gland Disorder
        Abscess of adrenal gland
        Acute adrenal insufficiency
        Bilateral massive adrenal hemorrhage
        Waterhouse-Friderichsen syndrome
        Adrenal cortical hypofunction
        Central adrenal insufficiency
        Adrenocorticotropin deficient adrenal insufficiency
        Adrenocorticotropin receptor defect
        Corticotropin-releasing hormone deficient adrenal insufficiency
        Corticotropin-releasing hormone receptor defect
        Primary adrenal insufficiency
        Decreased circulating aldosterone level
        Primary adrenocortical insufficiency
        Congenital Adrenal Gland Disorder
        Congenital adrenal hyperplasia
        3 beta-Hydroxysteroid dehydrogenase deficiency
        Adrenal Gland Hyperplasia II
        Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis
        Classic congenital adrenal hyperplasia
        Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
        Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
        Congenital lipoid adrenal hyperplasia due to STAR deficency
        Deficiency of steroid 11-beta-monooxygenase
        Deficiency of steroid 17-alpha-monooxygenase
        Macronodular adrenal hyperplasia
        Micronodular adrenal hyperplasia
        Multinodular Adrenal Hyperplasia
        Non-classic congenital adrenal hyperplasia
        Congenital adrenal hypoplasia
        Congenital adrenal hypoplasia, X-linked
        Miniature Adult Form of AHC
        Tuberculosis of adrenal glands

Professional guidelines

PubMed

Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis.

Mondin A, Barbot M, Voltan G, Tizianel I, Vedolin CK, Mazzeo P, Lazzara M, Boscaro M, Scaroni C, Ceccato F
J Endocrinol Invest 2023 Oct;46(10):1947-1959. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02099-z. PMID: 37079177 Free PMC Article

The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging.

Gao X, Yamazaki Y, Tezuka Y, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H
Endocrinol Metab (Seoul) 2021 Feb;36(1):12-21. Epub 2021 Feb 24 doi: 10.3803/EnM.2021.101. PMID: 33677921 Free PMC Article

Neonatal adrenal masses: do we have reliable criteria for differential diagnosis and expectant management?

Calisti A, Oriolo L, Molle P, Miele V, Spagnol L
Minerva Pediatr 2012 Jun;64(3):313-8. PMID: 22555324

See all (4)

Recent clinical studies

Etiology

Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis.

Cystic lymphangiomatous lesions of the adrenal gland: A clinicopathological study of 37 cases including previously unreported cysts with papillary endothelial proliferation.

Koperski Ł, Pihowicz P, Anysz-Grodzicka A, Górnicka B
Pathol Res Pract 2019 Jun;215(6):152385. Epub 2019 Mar 6 doi: 10.1016/j.prp.2019.03.014. PMID: 30862368

Non-neoplastic adrenal pseudocysts: A clinicopathologic study of 44 cases with potential insights into pathogenesis.

Koperski Ł, Pihowicz P, Fus ŁP, Bogdańska M, Górnicka B
Ann Diagn Pathol 2018 Oct;36:5-11. Epub 2018 Jun 21 doi: 10.1016/j.anndiagpath.2018.06.006. PMID: 29966833

Revisiting adrenal mass size as an indication for adrenalectomy.

Ballian N, Adler JT, Sippel RS, Chen H
J Surg Res 2009 Sep;156(1):16-20. Epub 2009 May 3 doi: 10.1016/j.jss.2009.03.071. PMID: 19592028

Tumors of the testis in intersex syndromes.

Levin HS
Urol Clin North Am 2000 Aug;27(3):543-51, x. doi: 10.1016/s0094-0143(05)70101-4. PMID: 10985153

See all (9)

Diagnosis

Can we differentiate neoplastic and non-neoplastic spontaneous adrenal bleeding? Imaging findings with radiopathologic correlation.

Karaosmanoglu AD, Uysal A, Arslan S, Sokmensuer C, Leblebici CB, Akata D, Ozmen MN, Karcaaltincaba M
Abdom Radiol (NY) 2021 Mar;46(3):1091-1102. Epub 2020 Sep 17 doi: 10.1007/s00261-020-02750-w. PMID: 32940758

Bilateral adrenal abnormalities: imaging review of different entities.

Alshahrani MA, Bin Saeedan M, Alkhunaizan T, Aljohani IM, Azzumeea FM
Abdom Radiol (NY) 2019 Jan;44(1):154-179. doi: 10.1007/s00261-018-1670-5. PMID: 29938331

The difficulties of pseudo-Cushing's syndrome (or "non-neoplastic hypercortisolism").

Chabre O
Ann Endocrinol (Paris) 2018 Jun;79(3):138-145. Epub 2018 Apr 30 doi: 10.1016/j.ando.2018.04.017. PMID: 29716734

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Endocrine and neuroendocrine cytopathology.

Bongiovanni M, La Rosa S, Sykiotis GP
Minerva Endocrinol 2018 Sep;43(3):294-304. Epub 2017 Sep 25 doi: 10.23736/S0391-1977.17.02744-4. PMID: 28949123

See all (39)

Therapy

The use of immunohistochemical expression of SF-1 and EMA in distinguishing adrenocortical tumors from renal neoplasms.

Enriquez ML, Lal P, Ziober A, Wang L, Tomaszewski JE, Bing Z
Appl Immunohistochem Mol Morphol 2012 Mar;20(2):141-5. doi: 10.1097/pai.0b013e31823605e7. PMID: 22553814

Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.

Ikoma A, Saito T, Murata M, Toyoshima H, Nakamura Y, Kawakami M, Sasano H, Ishikawa SE
Intern Med 2010;49(11):1017-21. Epub 2010 Jun 1 doi: 10.2169/internalmedicine.49.2808. PMID: 20519819

Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features.

Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H, Wakabayashi I
Intern Med 1997 Nov;36(11):804-9. doi: 10.2169/internalmedicine.36.804. PMID: 9392354

Medical management of non-neoplastic salivary gland disease.

Stuchell RN, Blitzer A, Mandel ID
Otolaryngol Clin North Am 1984 Nov;17(4):697-703. PMID: 6514360

See all (4)

Prognosis

Tumour microenvironment in pheochromocytoma and paraganglioma.

Martinelli S, Amore F, Canu L, Maggi M, Rapizzi E
Front Endocrinol (Lausanne) 2023;14:1137456. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1137456. PMID: 37033265 Free PMC Article

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas.

Tufton N, Hearnden RJ, Berney DM, Drake WM, Parvanta L, Chapple JP, Akker SA
Endocr Relat Cancer 2022 Nov 1;29(11):589-598. Epub 2022 Sep 19 doi: 10.1530/ERC-22-0020. PMID: 35975974 Free PMC Article

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome).

Findling JW, Raff H
Eur J Endocrinol 2017 May;176(5):R205-R216. Epub 2017 Feb 8 doi: 10.1530/EJE-16-0946. PMID: 28179447

Oncocytic lesions of the neuroendocrine system.

Canberk S, LiVolsi VA, Baloch Z
Adv Anat Pathol 2014 Mar;21(2):69-82. doi: 10.1097/PAP.0000000000000011. PMID: 24508690

See all (9)

Clinical prediction guides

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas.

Tufton N, Hearnden RJ, Berney DM, Drake WM, Parvanta L, Chapple JP, Akker SA
Endocr Relat Cancer 2022 Nov 1;29(11):589-598. Epub 2022 Sep 19 doi: 10.1530/ERC-22-0020. PMID: 35975974 Free PMC Article

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Findling JW, Raff H
Eur J Endocrinol 2017 May;176(5):R205-R216. Epub 2017 Feb 8 doi: 10.1530/EJE-16-0946. PMID: 28179447

IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis.

Peixoto Lira RC, Fedatto PF, Marco Antonio DS, Leal LF, Martinelli CE, de Castro M, Tucci S, Neder L, Ramalho L, Seidinger AL, Cardinalli I, Mastellaro MJ, Yunes JA, Brandalise SR, Tone LG, Rauber Antonini SR, Scrideli CA
Endocr Relat Cancer 2016 Jun;23(6):481-93. Epub 2016 May 16 doi: 10.1530/ERC-15-0426. PMID: 27185872

Increased expression of (pro)renin receptor in aldosterone-producing adenomas.

Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
Peptides 2013 Nov;49:68-73. Epub 2013 Sep 8 doi: 10.1016/j.peptides.2013.08.022. PMID: 24025599

See all (18)