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Non-Neoplastic Gonadal Disorder

MedGen UID:: 233774
•Concept ID:: C1335012
•: Disease or Syndrome

Definition

A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNon-Neoplastic Gonadal Disorder

Phenotypic abnormality
- Abnormality of prenatal development or birth
  - Fetal anomaly
    - Congenital Systemic Disorder
      - Abnormality of the genitourinary system
        Congenital Reproductive System Abnormality
        Non-Neoplastic Gonadal Disorder
        Gonadal agenesis
        Gonadal dysgenesis
        Gonadal dysgenesis with female appearance, male
        Gonadal dysgenesis, male
        Gonadoblastoma
        Infantilism, Sexual
        Mixed gonadal dysgenesis
        Ovarian dysgenesis 1
        Turner syndrome
        Monosomy X
        Mosaic Turner syndrome
        Turner syndrome due to structural X chromosome anomalies
        Hypogonadism
        Eunuchism
        Hypergonadotropic hypogonadism
        Congenital Hypergonadotropic Hypogonadism
        Follicle Stimulating Hormone Receptor Deficiency
        Hypogonadism with anosmia
        Hypogonadotropic hypogonadism 1 with or without anosmia
        Hypogonadotropic hypogonadism 2 with or without anosmia
        Hypogonadotropic hypogonadism 3 with or without anosmia
        Hypogonadotropic hypogonadism 4 with or without anosmia
        Hypogonadotropic hypogonadism 5 with or without anosmia
        Hypogonadotropic hypogonadism 6 with or without anosmia
        Hypogonadotropic hypogonadism
        Acquired Hypogonadotropic Hypogonadism
        Congenital hypogonadotropic hypogonadism
        Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita
        Isolated Hypogonadotropic Hypogonadism
        Klinefelter syndrome
        Male hypogonadism
        Acquired testicular failure
        Congenital Testicular Failure
        Primary testicular failure

Professional guidelines

PubMed

Non-invasive Resolution of Pathological Ovarian Masses with Homeopathic Treatment-A Case Series.

Ramanan VE, Radhakrishnan R
Homeopathy 2022 Aug;111(3):194-201. Epub 2021 Dec 27 doi: 10.1055/s-0041-1735849. PMID: 34959245

Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non-palpable testicular lesions.

Pozza C, Gianfrilli D, Fattorini G, Giannetta E, Barbagallo F, Nicolai E, Cristini C, Di Pierro GB, Franco G, Lenzi A, Sidhu PS, Cantisani V, Isidori AM
Andrology 2016 Nov;4(6):1193-1203. Epub 2016 Aug 27 doi: 10.1111/andr.12260. PMID: 27565451 Free PMC Article

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.

Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

See all (7)

Recent clinical studies

Etiology

The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults.

Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425 Free PMC Article

Gonadoblastoma: origin and outcome.

Roth LM, Cheng L
Hum Pathol 2020 Jun;100:47-53. Epub 2019 Dec 2 doi: 10.1016/j.humpath.2019.11.005. PMID: 31805291

Cytokines in peritoneal fluid of ovarian neoplasms.

de Lima CA, Silva Rodrigues IS, Martins-Filho A, Côbo Micheli D, Martins Tavares-Murta B, Candido Murta EF, Simões Nomelini R
J Obstet Gynaecol 2020 Apr;40(3):401-405. Epub 2019 Sep 3 doi: 10.1080/01443615.2019.1633516. PMID: 31476946

Imaging of non-neoplastic intratesticular masses.

Bhatt S, Jafri SZ, Wasserman N, Dogra VS
Diagn Interv Radiol 2011 Mar;17(1):52-63. Epub 2010 Jun 30 doi: 10.4261/1305-3825.DIR.3116-09.0. PMID: 20677130

Pathology of ovarian cancer precursors.

Scully RE
J Cell Biochem Suppl 1995;23:208-18. doi: 10.1002/jcb.240590928. PMID: 8747398

See all (130)

Diagnosis

Ultrasonographic diagnosis and surgical outcomes of adnexal masses in children and adolescents.

Kang GG, So KA, Hwang JY, Kim NR, Yang EJ, Shim SH, Lee SJ, Kim TJ
Sci Rep 2022 Mar 10;12(1):3949. doi: 10.1038/s41598-022-08015-4. PMID: 35273292 Free PMC Article

Imaging of scrotal masses.

Sharbidre KG, Lockhart ME
Abdom Radiol (NY) 2020 Jul;45(7):2087-2108. doi: 10.1007/s00261-019-02395-4. PMID: 31919649

Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.

Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819

Pathology of the adnexal mass.

Bennett JA, Oliva E
Clin Obstet Gynecol 2015 Mar;58(1):3-27. doi: 10.1097/GRF.0000000000000082. PMID: 25608250

Paratesticular tumor-like lesions.

Oliva E, Young RH
Semin Diagn Pathol 2000 Nov;17(4):340-58. PMID: 11202549

See all (173)

Therapy

Dubious effects of methadone as an "anticancer" drug on ovarian cancer cell-lines and patient-derived tumor-spheroids.

Fiegl H, Hagenbuchner J, Kyvelidou C, Seeber B, Sopper S, Tsibulak I, Wieser V, Reiser E, Roessler J, Huhtinen K, Carpén O, Parson W, Sprung S, Marth C, Ausserlechner MJ, Zeimet AG
Gynecol Oncol 2022 Apr;165(1):129-136. Epub 2022 Jan 13 doi: 10.1016/j.ygyno.2022.01.008. PMID: 35033381

Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms.

Micheli DC, Jammal MP, Martins-Filho A, Côrtes JRXM, Souza CN, Nomelini RS, Murta EFC, Tavares-Murta BM
Biomarkers 2020 Sep;25(6):474-482. Epub 2020 Jun 28 doi: 10.1080/1354750X.2020.1783574. PMID: 32544350

Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.

Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819

Ovarian-Sparing Surgery in Pediatric Benign Ovarian Tumors.

Abbas PI, Dietrich JE, Francis JA, Brandt ML, Cass DL, Lopez ME
J Pediatr Adolesc Gynecol 2016 Oct;29(5):506-510. Epub 2016 Apr 11 doi: 10.1016/j.jpag.2016.03.009. PMID: 27079914

Ovarian masses in children and adolescents - an analysis of 521 clinical cases.

Zhang M, Jiang W, Li G, Xu C
J Pediatr Adolesc Gynecol 2014 Jun;27(3):e73-7. Epub 2013 Oct 21 doi: 10.1016/j.jpag.2013.07.007. PMID: 24157281

See all (30)

Prognosis

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.

Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887

The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults.

Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425 Free PMC Article

Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.

Diao B, Yang P
Pathol Oncol Res 2021;27:1609855. Epub 2021 Aug 25 doi: 10.3389/pore.2021.1609855. PMID: 34512203 Free PMC Article

Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.

Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256 Free PMC Article

Aspiration cytology of neoplastic and non-neoplastic ovarian cysts: is it accurate?

Ganjei P, Dickinson B, Harrison T, Nassiri M, Lu Y
Int J Gynecol Pathol 1996 Apr;15(2):94-101. doi: 10.1097/00004347-199604000-00002. PMID: 8786211

See all (71)

Clinical prediction guides

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.

Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887

The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults.

Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425 Free PMC Article

Ultrasonographic diagnosis and surgical outcomes of adnexal masses in children and adolescents.

Kang GG, So KA, Hwang JY, Kim NR, Yang EJ, Shim SH, Lee SJ, Kim TJ
Sci Rep 2022 Mar 10;12(1):3949. doi: 10.1038/s41598-022-08015-4. PMID: 35273292 Free PMC Article

Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.

Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256 Free PMC Article

Pathology of ovarian cancer precursors.

Scully RE
J Cell Biochem Suppl 1995;23:208-18. doi: 10.1002/jcb.240590928. PMID: 8747398

See all (74)

Recent systematic reviews

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.

Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887

Dexamethasone suppression test versus selective ovarian and adrenal vein catheterization in identifying virilizing tumors in postmenopausal hyperandrogenism - a systematic review and meta-analysis.

Tng EL, Tan JM
Gynecol Endocrinol 2021 Jul;37(7):600-608. Epub 2021 Mar 4 doi: 10.1080/09513590.2021.1897099. PMID: 33660585

A Systematic Review on the Use of Qualitative and Quantitative Contrast-enhanced Ultrasound in Diagnosing Testicular Abnormalities.

Pinto SPS, Huang DY, Dinesh AA, Sidhu PS, Ahmed K
Urology 2021 Aug;154:16-23. Epub 2021 Feb 20 doi: 10.1016/j.urology.2021.02.012. PMID: 33621585

See all (3)

MedGen

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Non-Neoplastic Gonadal Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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