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Pancreatic signet ring cell adenocarcinoma

MedGen UID:
233834
Concept ID:
C1335317
Neoplastic Process
Synonyms: pancreas signet ring cell carcinoma; pancreatic signet ring cell adenocarcinoma; Pancreatic Signet Ring Cell Carcinoma; pancreatic signet ring cell carcinoma; pancreatic signet Ring cell carcinoma; Pancreatic Signet-Ring Cell Carcinoma; Signet Ring Cell Carcinoma of Pancreas; signet Ring cell carcinoma of pancreas; Signet Ring Cell Carcinoma of the Pancreas; signet Ring cell carcinoma of the pancreas
 
Monarch Initiative: MONDO:0002666

Definition

A rare pancreatic ductal adenocarcinoma with poor prognosis. It is characterized by the presence of malignant signet ring cells infiltrating the pancreatic parenchyma in an individual cell pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic signet ring cell adenocarcinoma

Professional guidelines

PubMed

Patel M, Hans HS, Pan K, Khan H, Donath E, Caldera H
Am J Clin Oncol 2018 Dec;41(12):1176-1184. doi: 10.1097/COC.0000000000000447. PMID: 29672365
Dursun N, Feng J, Basturk O, Bandyopadhyay S, Cheng JD, Adsay VN
Virchows Arch 2010 Dec;457(6):643-9. Epub 2010 Oct 8 doi: 10.1007/s00428-010-0978-5. PMID: 20931225Free PMC Article
Fan Z, van de Rijn M, Montgomery K, Rouse RV
Mod Pathol 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20. PMID: 12591966

Recent clinical studies

Etiology

Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Nie D, Yang J, Zheng H, Lai G, Wang F, Cao J, Gong C
BMC Gastroenterol 2023 Mar 9;23(1):62. doi: 10.1186/s12876-023-02650-5. PMID: 36894876Free PMC Article
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Li Y, Zhu Z, Ma F, Xue L, Tian Y
Cancer Med 2020 Sep;9(18):6617-6628. Epub 2020 Aug 3 doi: 10.1002/cam4.3342. PMID: 32744431Free PMC Article

Diagnosis

Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Luchini C, Grillo F, Fassan M, Vanoli A, Capelli P, Paolino G, Ingravallo G, Renzulli G, Doglioni C, D'Amuri A, Mattiolo P, Pecori S, Parente P, Florena AM, Zamboni G, Scarpa A
Pathologica 2020 Sep;112(3):210-226. doi: 10.32074/1591-951X-167. PMID: 33179623Free PMC Article
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
El Hussein S, Khader SN
Diagn Cytopathol 2019 Dec;47(12):1314-1320. Epub 2019 Oct 10 doi: 10.1002/dc.24324. PMID: 31599130

Therapy

Yang Y, Akashi Y, Shimomura O, Tateno H, Saito S, Hiemori K, Miyazaki Y, Furuta T, Kitaguchi D, Kuroda Y, Pakavarin L, Oda T
Gastric Cancer 2022 Sep;25(5):896-905. Epub 2022 Jun 17 doi: 10.1007/s10120-022-01312-x. PMID: 35715659
Li Y, Zhu Z, Ma F, Xue L, Tian Y
Cancer Med 2020 Sep;9(18):6617-6628. Epub 2020 Aug 3 doi: 10.1002/cam4.3342. PMID: 32744431Free PMC Article
Levinsky NC, Morris MC, Wima K, Sussman JJ, Ahmad SA, Cloyd JM, Kimbrough C, Fournier K, Lee A, Dineen S, Dessureault S, Veerapong J, Baumgartner JM, Clarke C, Zaidi MY, Staley CA, Maithel SK, Leiting J, Grotz T, Lambert L, Hendrix RJ, Ronnekleiv-Kelly S, Pokrzywa C, Raoof M, Eng OS, Johnston FM, Greer J, Patel SH
J Gastrointest Surg 2020 Jan;24(1):155-164. Epub 2019 Aug 19 doi: 10.1007/s11605-019-04336-4. PMID: 31428960
Radojkovic M, Ilic D, Ilic I
Tumori 2017 Nov 15;103(Suppl. 1):e50-e52. doi: 10.5301/tj.5000671. PMID: 28708232
de Steur WO, Dikken JL, Hartgrink HH
Dig Surg 2013;30(2):96-103. Epub 2013 Jul 18 doi: 10.1159/000350873. PMID: 23867585

Prognosis

Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Nie D, Lan Q, Huang Y, Fang C, Cao Y, Chen Y
BMC Gastroenterol 2022 Nov 16;22(1):458. doi: 10.1186/s12876-022-02543-z. PMID: 36384527Free PMC Article
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682

Clinical prediction guides

Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Nakamura M, Inagaki F, Takemura N, Yoshizaki Y, Ito K, Mihara F, Kokudo N
Clin J Gastroenterol 2023 Jun;16(3):482-487. Epub 2023 Mar 20 doi: 10.1007/s12328-023-01783-0. PMID: 36939986
Nie D, Lan Q, Huang Y, Fang C, Cao Y, Chen Y
BMC Gastroenterol 2022 Nov 16;22(1):458. doi: 10.1186/s12876-022-02543-z. PMID: 36384527Free PMC Article
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682

Recent systematic reviews

Rossi C, Gallotti A, Messina A, Cobianchi L, Inzani F, Lucioni M, Vanoli A
Pathol Res Pract 2024 Jan;253:155049. Epub 2023 Dec 21 doi: 10.1016/j.prp.2023.155049. PMID: 38176311

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