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Papillary thymic adenocarcinoma

MedGen UID:: 233836
•Concept ID:: C1335327
•: Neoplastic Process

Synonyms:	Papillary Carcinoma of the Thymus; papillary carcinoma of the Thymus; Papillary Carcinoma of Thymus; papillary carcinoma of Thymus; papillary thymic adenocarcinoma; Thymic Low Grade Papillary Adenocarcinoma; Thymic Low-Grade Papillary Adenocarcinoma; Thymic Papillary Adenocarcinoma; thymic papillary adenocarcinoma; Thymic Papillary Carcinoma; thymic papillary carcinoma; thymus papillary adenocarcinoma; Thymus Papillary Carcinoma; Thymus papillary carcinoma

Monarch Initiative:	MONDO:0003534

Definition

A rare low-grade primary thymic adenocarcinoma characterized by a papillary growth pattern. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPapillary thymic adenocarcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Papillary adenocarcinoma
        Papillary thymic adenocarcinoma

Professional guidelines

PubMed

Mediastinal images resembling thymus following 131-I treatment for thyroid cancer.

Montella L, Caraglia M, Abbruzzese A, Soricelli A, Caputi M, Squame G, Salvatore M, Del Prete S, Palmieri G
Monaldi Arch Chest Dis 2005 Jun;63(2):114-7. doi: 10.4081/monaldi.2005.649. PMID: 16128228

See all (1)

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841

Ectopic Thyroid Tissue: Immunohistochemistry and Molecular Analysis.

Lin DM, Javidiparsijani S, Vardouniotis A, Buckingham L, Reddy SB, Gattuso P
Appl Immunohistochem Mol Morphol 2018 Nov/Dec;26(10):734-739. doi: 10.1097/PAI.0000000000000515. PMID: 28362711

In situ preservation of the inferior parathyroid gland during central neck dissection for papillary thyroid carcinoma.

Wang JB, Wu K, Shi LH, Sun YY, Li FB, Xie L
Br J Surg 2017 Oct;104(11):1514-1522. Epub 2017 Aug 7 doi: 10.1002/bjs.10581. PMID: 28782797

Development of prognostic signatures for intermediate-risk papillary thyroid cancer.

Brennan K, Holsinger C, Dosiou C, Sunwoo JB, Akatsu H, Haile R, Gevaert O
BMC Cancer 2016 Sep 15;16(1):736. doi: 10.1186/s12885-016-2771-6. PMID: 27633254 Free PMC Article

Spindle epithelial tumor with thymus-like differentiation: A case report and comprehensive review of the literature and treatment options.

Recondo G Jr, Busaidy N, Erasmus J, Williams MD, Johnson FM
Head Neck 2015 May;37(5):746-54. Epub 2014 May 5 doi: 10.1002/hed.23634. PMID: 24677409

See all (10)

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Thymic Adenocarcinoma with Positivity for Thyroid Transcription Factor-1 and a BRAF V600E Mutation.

Yorozuya T, Otsuka M, Ichihara S, Fujimori K, Kitamura C, Takahashi T, Mori M, Cho Y, Chiba H
Intern Med 2022 Feb 1;61(3):385-388. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7623-21. PMID: 34275983 Free PMC Article

Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis.

Boyraz B, Sadow PM, Asa SL, Dias-Santagata D, Nosé V, Mete O
Endocr Pathol 2021 Sep;32(3):327-335. Epub 2021 May 21 doi: 10.1007/s12022-021-09683-0. PMID: 34019236 Free PMC Article

Ectopic Thyroid Tissue: Immunohistochemistry and Molecular Analysis.

Lin DM, Javidiparsijani S, Vardouniotis A, Buckingham L, Reddy SB, Gattuso P
Appl Immunohistochem Mol Morphol 2018 Nov/Dec;26(10):734-739. doi: 10.1097/PAI.0000000000000515. PMID: 28362711

Primary carcinomas of the thymus gland.

Ritter JH, Wick MR
Semin Diagn Pathol 1999 Feb;16(1):18-31. PMID: 10355651

See all (30)

Therapy

I-131 false-positive uptake in a thymic cyst with expression of the sodium-iodide symporter: A case report.

Yano E, Nakajo M, Jinguji M, Tani A, Kitazono I, Yoshiura T
Medicine (Baltimore) 2022 Jul 1;101(26):e29282. doi: 10.1097/MD.0000000000029282. PMID: 35777066 Free PMC Article

Incidental radiologic finding of an anterior superior mediastinal mass masquerading as metastatic thyroid cancer in patients with treated thyroid cancer.

McCullen MK, Miller JL
Endocr Pract 2011 Jan-Feb;17(1):65-9. doi: 10.4158/EP10111.OR. PMID: 20713344

Papillary adenocarcinoma developed in a thymic cyst.

Morikawa H, Tanaka T, Hamaji M, Ueno Y, Hara A
Gen Thorac Cardiovasc Surg 2010 Jun;58(6):295-7. Epub 2010 Jun 13 doi: 10.1007/s11748-009-0518-x. PMID: 20549461

Mediastinal images resembling thymus following 131-I treatment for thyroid cancer.

Montella L, Caraglia M, Abbruzzese A, Soricelli A, Caputi M, Squame G, Salvatore M, Del Prete S, Palmieri G
Monaldi Arch Chest Dis 2005 Jun;63(2):114-7. doi: 10.4081/monaldi.2005.649. PMID: 16128228

Papillary adenocarcinoma in a thymic cyst: a pitfall of thoracoscopic excision.

Zaitlin N, Rozenman J, Yellin A
Ann Thorac Surg 2003 Oct;76(4):1279-81. doi: 10.1016/s0003-4975(03)00524-1. PMID: 14530028

See all (8)

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.

Thymic adenocarcinoma accompanied by type A thymoma and pulmonary minimally invasive adenocarcinoma and harboring distinct gene alterations: A case report.

Zheng YW, Bai LL, Jiang GY, Lin XY, Liu Y, Xu HT
Medicine (Baltimore) 2021 Apr 16;100(15):e25254. doi: 10.1097/MD.0000000000025254. PMID: 33847622 Free PMC Article

Primary spindle cell lesions of the thyroid gland; an overview.

Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961

Primary carcinomas of the thymus gland.

Ritter JH, Wick MR
Semin Diagn Pathol 1999 Feb;16(1):18-31. PMID: 10355651

Thymomas.

LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046

See all (16)

Clinical prediction guides

Cribriform Morular Thyroid Carcinoma - Ultimobranchial Pouch-Related? Deep Molecular Insights of a Unique Case.

Dettmer MS, Hürlimann S, Scheuble L, Vassella E, Perren A, Wicke C
Endocr Pathol 2023 Sep;34(3):342-348. Epub 2023 May 30 doi: 10.1007/s12022-023-09775-z. PMID: 37249797 Free PMC Article

Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis.

Boyraz B, Sadow PM, Asa SL, Dias-Santagata D, Nosé V, Mete O
Endocr Pathol 2021 Sep;32(3):327-335. Epub 2021 May 21 doi: 10.1007/s12022-021-09683-0. PMID: 34019236 Free PMC Article

Ectopic thymoma can mimic benign and malignant thyroid lesions on fine needle aspiration cytology: a case report and literature review.

Taweevisit M, Sampatanukul P, Thorner PS
Acta Cytol 2013;57(2):213-20. Epub 2013 Feb 28 doi: 10.1159/000346705. PMID: 23406665

Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?

Eloy C, Vinagre J, Cameselle-Teijeiro J, Paiva ME, Soares P, Sobrinho-Simões M
Int J Surg Pathol 2011 Apr;19(2):276-80. Epub 2011 Jan 6 doi: 10.1177/1066896910393506. PMID: 21216781

Thymomas.

LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046

See all (7)

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Papillary thymic adenocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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