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Papillary urothelial neoplasm

MedGen UID:
233837
•Concept ID:
C1335329
•
Neoplastic Process
Synonyms: inverted papilloma of urinary tract; Papillary Transitional Cell Neoplasm of the Urinary Tract; papillary transitional cell neoplasm of the urinary tract; Papillary Urothelial Neoplasm; papillary urothelial neoplasm; urinary tract papillary transitional cell benign neoplasm; Urinary Tract Papillary Transitional Cell Neoplasm; urinary tract papillary transitional cell neoplasm; urothelium papillary epithelial neoplasm
 
Monarch Initiative: MONDO:0003443

Definition

A benign or malignant neoplasm that arises from the urothelial lining of the urinary tract and is characterized by papillary formations. [from NCI]

Professional guidelines

PubMed

Evaluation of MUC1 and P53 expressions in noninvasive papillary urothelial neoplasms of bladder, their relationship with tumor grade and role in the differential diagnosis.
Kaymaz E, Ozer E, Unverdi H, Hucumenoglu S
Indian J Pathol Microbiol 2017 Oct-Dec;60(4):510-514. doi: 10.4103/IJPM.IJPM_204_16. PMID: 29323063
Cytomorphological characteristics of low-grade papillary urothelial carcinoma for differential diagnosis from benign papillary urothelial lesions: logistic regression analysis in SurePath(™) liquid-based voided urine cytology.
Chung YR, Won JK, Park IA, Moon KC, Chung SY, Lee K, Ryu HS
Cytopathology 2016 Apr;27(2):83-90. Epub 2015 Jan 12 doi: 10.1111/cyt.12230. PMID: 25580773
2-micrometer continuous wave laser treatment for multiple non-muscle-invasive bladder cancer with intravesical instillation of epirubicin.
Liu H, Xue S, Ruan Y, Sun X, Han B, Xia S
Lasers Surg Med 2011 Jan;43(1):15-20. doi: 10.1002/lsm.21014. PMID: 21254138

Recent clinical studies

Etiology

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article

Diagnosis

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Noninvasive papillary urothelial neoplasia (NIPUN): Renaming cancer.
Jones TD, Cheng L
Urol Oncol 2021 May;39(5):286-290. Epub 2021 Jan 1 doi: 10.1016/j.urolonc.2020.12.007. PMID: 35550107
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141
Variant hairy cell leukemia following papillary urothelial neoplasm of bladder.
Beyan C, Kaptan K
J Coll Physicians Surg Pak 2014 Mar;24 Suppl 1:S27-8. PMID: 24717996
Hexaminolevulinate-induced fluorescence versus white light during transurethral resection of noninvasive bladder tumor: does it reduce recurrences?
Karaolides T, Skolarikos A, Bourdoumis A, Konandreas A, Mygdalis V, Thanos A, Deliveliotis C
Urology 2012 Aug;80(2):354-9. doi: 10.1016/j.urology.2012.03.067. PMID: 22857752
2-micrometer continuous wave laser treatment for multiple non-muscle-invasive bladder cancer with intravesical instillation of epirubicin.
Liu H, Xue S, Ruan Y, Sun X, Han B, Xia S
Lasers Surg Med 2011 Jan;43(1):15-20. doi: 10.1002/lsm.21014. PMID: 21254138

Prognosis

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Noninvasive papillary urothelial neoplasia (NIPUN): Renaming cancer.
Jones TD, Cheng L
Urol Oncol 2021 May;39(5):286-290. Epub 2021 Jan 1 doi: 10.1016/j.urolonc.2020.12.007. PMID: 35550107
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article

Clinical prediction guides

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Grading of Urothelial Carcinoma and The New "World Health Organisation Classification of Tumours of the Urinary System and Male Genital Organs 2016".
Compérat EM, Burger M, Gontero P, Mostafid AH, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Sylvester RJ, Zigeuner R, Babjuk M
Eur Urol Focus 2019 May;5(3):457-466. Epub 2018 Jan 20 doi: 10.1016/j.euf.2018.01.003. PMID: 29366854
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

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