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Gastric T-Cell Non-Hodgkin Lymphoma

MedGen UID:
233872
•Concept ID:
C1335484
•
Neoplastic Process
Synonyms: Gastric T-Cell Non-Hodgkin's Lymphoma; Primary Gastric T-Cell Lymphoma; Primary Gastric T-Cell Non-Hodgkin's Lymphoma; Primary T-Cell Lymphoma of Stomach; Primary T-Cell Lymphoma of the Stomach

Definition

A rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric T-Cell Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Combination therapy of DKK1 inhibition and NKG2D chimeric antigen receptor T cells for the treatment of gastric cancer.
Zhang Y, Liang K, Zhou X, Zhang X, Xu H, Dai H, Song X, Yang X, Liu B, Shi T, Wei J
Cancer Sci 2023 Jul;114(7):2798-2809. Epub 2023 May 7 doi: 10.1111/cas.15828. PMID: 37151176Free PMC Article
Clinical Implications and Management of Non-BIA-ALCL Breast Implant Capsular Pathology.
Vorstenbosch J, Chu JJ, Ariyan CE, McCarthy CM, Disa JJ, Nelson JA
Plast Reconstr Surg 2023 Jan 1;151(1):20e-30e. Epub 2022 Oct 4 doi: 10.1097/PRS.0000000000009780. PMID: 36194076Free PMC Article
Gastrointestinal lymphomas: French Intergroup clinical practice recommendations for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFH).
Matysiak-Budnik T, Fabiani B, Hennequin C, Thieblemont C, Malamut G, Cadiot G, Bouché O, Ruskoné-Fourmestraux A
Dig Liver Dis 2018 Feb;50(2):124-131. Epub 2017 Dec 18 doi: 10.1016/j.dld.2017.12.006. PMID: 29301732

Recent clinical studies

Etiology

Gut inflammation and tumorigenesis: every site has a different tale to tell.
Vanoli A, Parente P, Fassan M, Mastracci L, Grillo F
Intern Emerg Med 2023 Nov;18(8):2169-2179. Epub 2023 May 30 doi: 10.1007/s11739-023-03320-w. PMID: 37249755Free PMC Article
Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Gastrointestinal non-Hodgkin lymphomas.
Olszewska-Szopa M, Wróbel T
Adv Clin Exp Med 2019 Aug;28(8):1119-1124. doi: 10.17219/acem/94068. PMID: 31414733
Enteropathy-type T-cell lymphoma.
Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK
Am J Clin Pathol 2007 May;127(5):701-6. doi: 10.1309/nw2bk1dxb0eqg55h. PMID: 17511112
Primary gastrointestinal lymphomas.
Cooper DL, Doria R, Salloum E
Gastroenterologist 1996 Mar;4(1):54-64. PMID: 8689146

Diagnosis

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Gastrointestinal non-Hodgkin lymphomas.
Olszewska-Szopa M, Wróbel T
Adv Clin Exp Med 2019 Aug;28(8):1119-1124. doi: 10.17219/acem/94068. PMID: 31414733
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Enteropathy-type T-cell lymphoma.
Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK
Am J Clin Pathol 2007 May;127(5):701-6. doi: 10.1309/nw2bk1dxb0eqg55h. PMID: 17511112

Therapy

Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial.
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
The BiTE (bispecific T-cell engager) platform: Development and future potential of a targeted immuno-oncology therapy across tumor types.
Einsele H, Borghaei H, Orlowski RZ, Subklewe M, Roboz GJ, Zugmaier G, Kufer P, Iskander K, Kantarjian HM
Cancer 2020 Jul 15;126(14):3192-3201. Epub 2020 May 13 doi: 10.1002/cncr.32909. PMID: 32401342
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M
Int J Mol Med 2020 Feb;45(2):279-297. Epub 2019 Dec 4 doi: 10.3892/ijmm.2019.4418. PMID: 31894255Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Prognosis

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group.
Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y, Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T, Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H, Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K
Lancet Haematol 2023 Jun;10(6):e419-e432. Epub 2023 May 8 doi: 10.1016/S2352-3026(23)00072-8. PMID: 37167992
The epidemiology and prognosis of patients with primary gastric T-cell lymphoma in the SEER program.
Zhang M, Xiao F, Lin M, Chen M, Hou J, Huang H
Cancer Med 2023 Jan;12(1):84-98. Epub 2022 Jun 13 doi: 10.1002/cam4.4936. PMID: 35698430Free PMC Article
Gastrointestinal lymphomas: French Intergroup clinical practice recommendations for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFH).
Matysiak-Budnik T, Fabiani B, Hennequin C, Thieblemont C, Malamut G, Cadiot G, Bouché O, Ruskoné-Fourmestraux A
Dig Liver Dis 2018 Feb;50(2):124-131. Epub 2017 Dec 18 doi: 10.1016/j.dld.2017.12.006. PMID: 29301732
Diagnosis and management of rare gastrointestinal lymphomas.
Hawkes EA, Wotherspoon A, Cunningham D
Leuk Lymphoma 2012 Dec;53(12):2341-50. Epub 2012 Jun 21 doi: 10.3109/10428194.2012.695780. PMID: 22616672
Gastrointestinal lymphoma.
Isaacson PG
Hum Pathol 1994 Oct;25(10):1020-9. doi: 10.1016/0046-8177(94)90060-4. PMID: 7927306

Clinical prediction guides

The epidemiology and prognosis of patients with primary gastric T-cell lymphoma in the SEER program.
Zhang M, Xiao F, Lin M, Chen M, Hou J, Huang H
Cancer Med 2023 Jan;12(1):84-98. Epub 2022 Jun 13 doi: 10.1002/cam4.4936. PMID: 35698430Free PMC Article
Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial.
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistance.
Olino K, Park T, Ahuja N
Semin Cancer Biol 2020 Oct;65:114-122. Epub 2020 Jan 3 doi: 10.1016/j.semcancer.2020.01.001. PMID: 31911188

Recent systematic reviews

Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies.
Schierhout G, McGregor S, Gessain A, Einsiedel L, Martinello M, Kaldor J
Lancet Infect Dis 2020 Jan;20(1):133-143. Epub 2019 Oct 21 doi: 10.1016/S1473-3099(19)30402-5. PMID: 31648940
Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma.
Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ
World J Gastroenterol 2017 Sep 21;23(35):6491-6499. doi: 10.3748/wjg.v23.i35.6491. PMID: 29085199Free PMC Article
Primary Gastrointestinal Lymphoma: A Retrospective Multicenter Clinical Study of 415 Cases in Chinese Province of Guangdong and a Systematic Review Containing 5075 Chinese Patients.
Chen Y, Chen Y, Chen S, Wu L, Xu L, Lian G, Yang K, Li Y, Zeng L, Huang K
Medicine (Baltimore) 2015 Nov;94(47):e2119. doi: 10.1097/MD.0000000000002119. PMID: 26632732Free PMC Article

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