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Reticulin Fibrosis of the Bone Marrow

MedGen UID:
233921
•Concept ID:
C1335762
•
Finding

Definition

Increased reticular fiber deposition within bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReticulin Fibrosis of the Bone Marrow

Professional guidelines

PubMed

HLH and TET2 Mutation Presenting after First Cycle of CLL Treatment.
Geiger AJ, Yasar DG, Sitwala KV
Clin Med Res 2023 Sep;21(3):155-158. doi: 10.3121/cmr.2023.1804. PMID: 37985171Free PMC Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Recent clinical studies

Etiology

Bone marrow fibrosis is associated with non-response to CD19 CAR T-cell therapy in B-acute lymphoblastic leukemia.
Anil J, Alnemri A, Lytle A, Lockhart B, Anil AE, Baumgartner M, Gebre K, McFerran J, Grupp SA, Rheingold SR, Pillai V
Am J Hematol 2023 Dec;98(12):1888-1897. Epub 2023 Sep 18 doi: 10.1002/ajh.27098. PMID: 37718626
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Zahr AA, Salama ME, Carreau N, Tremblay D, Verstovsek S, Mesa R, Hoffman R, Mascarenhas J
Haematologica 2016 Jun;101(6):660-71. doi: 10.3324/haematol.2015.141283. PMID: 27252511Free PMC Article

Diagnosis

Morphologic Characteristics of Myelodysplastic Syndromes.
Yuen LD, Hasserjian RP
Clin Lab Med 2023 Dec;43(4):577-596. Epub 2023 Aug 9 doi: 10.1016/j.cll.2023.06.003. PMID: 37865504
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
TAFRO syndrome: A disease that known is half cured.
Chen T, Feng C, Zhang X, Zhou J
Hematol Oncol 2023 Aug;41(3):310-322. Epub 2022 Oct 3 doi: 10.1002/hon.3075. PMID: 36148768
Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease.
Nishimura Y, Fajgenbaum DC, Pierson SK, Iwaki N, Nishikori A, Kawano M, Nakamura N, Izutsu K, Takeuchi K, Nishimura MF, Maeda Y, Otsuka F, Yoshizaki K, Oksenhendler E, van Rhee F, Sato Y
Am J Hematol 2021 Oct 1;96(10):1241-1252. Epub 2021 Jul 28 doi: 10.1002/ajh.26292. PMID: 34265103Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Therapy

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Pharmacotherapy of Myelofibrosis.
Tremblay D, Marcellino B, Mascarenhas J
Drugs 2017 Sep;77(14):1549-1563. doi: 10.1007/s40265-017-0797-y. PMID: 28791654
Impact of bone marrow pathology on the clinical management of Philadelphia chromosome-negative myeloproliferative neoplasms.
Pozdnyakova O, Hasserjian RP, Verstovsek S, Orazi A
Clin Lymphoma Myeloma Leuk 2015 May;15(5):253-61. Epub 2014 Nov 18 doi: 10.1016/j.clml.2014.11.002. PMID: 25515354
Therapy-related changes of the bone marrow in chronic idiopathic myelofibrosis.
Thiele J, Kvasnicka HM, Schmitt-Gräff A, Hülsemann R, Diehl V
Histol Histopathol 2004 Jan;19(1):239-50. doi: 10.14670/HH-19.239. PMID: 14702192

Prognosis

Morphologic Characteristics of Myelodysplastic Syndromes.
Yuen LD, Hasserjian RP
Clin Lab Med 2023 Dec;43(4):577-596. Epub 2023 Aug 9 doi: 10.1016/j.cll.2023.06.003. PMID: 37865504
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Zahr AA, Salama ME, Carreau N, Tremblay D, Verstovsek S, Mesa R, Hoffman R, Mascarenhas J
Haematologica 2016 Jun;101(6):660-71. doi: 10.3324/haematol.2015.141283. PMID: 27252511Free PMC Article

Clinical prediction guides

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Improved survival of patients with myelofibrosis in the last decade: Single-center experience.
Masarova L, Bose P, Pemmaraju N, Daver NG, Sasaki K, Chifotides HT, Zhou L, Kantarjian HM, Estrov Z, Verstovsek S
Cancer 2022 Apr 15;128(8):1658-1665. Epub 2022 Jan 25 doi: 10.1002/cncr.34103. PMID: 35077575
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Mastocytosis and fibrosis: role of cytokines.
Li CY, Baek JY
Int Arch Allergy Immunol 2002 Feb;127(2):123-6. doi: 10.1159/000048182. PMID: 11919421

Recent systematic reviews

TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review.
Belyaeva E, Rubenstein A, Pierson SK, Dalldorf D, Frank D, Lim MS, Fajgenbaum DC
Hematol Oncol 2022 Apr;40(2):191-201. Epub 2022 Feb 18 doi: 10.1002/hon.2969. PMID: 35104370Free PMC Article

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