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Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

MedGen UID:
233970
Concept ID:
C1332234
Neoplastic Process
Synonyms: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent; acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent; Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; AML and myelodysplastic syndromes related to alkylating agent
SNOMED CT: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent (766045006)
 
Monarch Initiative: MONDO:0015164
Orphanet: ORPHA102379

Definition

A subgroup of therapy-related myeloid neoplasms (t-MN), associated with a treatment of an unrelated neoplastic or autoimmune disease with cytotoxic agents, like cyclophosphamid, platins, melphalan and others. The neoplastic cells typically harbour unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. It usually presents with multilineage dysplasia and cytopenias 5-10 years after exposure, with symptoms related to the degree of bone marrow failure and the corresponding cytopenia (fatigue, bleeding and bruising, recurrent infections, bone pain). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

Professional guidelines

PubMed

Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S
J Clin Oncol 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. PMID: 12610191
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Beelen DW, Trenschel R, Stelljes M, Groth C, Masszi T, Reményi P, Wagner-Drouet EM, Hauptrock B, Dreger P, Luft T, Bethge W, Vogel W, Ciceri F, Peccatori J, Stölzel F, Schetelig J, Junghanß C, Grosse-Thie C, Michallet M, Labussiere-Wallet H, Schaefer-Eckart K, Dressler S, Grigoleit GU, Mielke S, Scheid C, Holtick U, Patriarca F, Medeot M, Rambaldi A, Micò MC, Niederwieser D, Franke GN, Hilgendorf I, Winkelmann NR, Russo D, Socié G, Peffault de Latour R, Holler E, Wolff D, Glass B, Casper J, Wulf G, Menzel H, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, Grass S, Iori AP, Finke J, Benedetti F, Pichlmeier U, Hemmelmann C, Tribanek M, Klein A, Mylius HA, Baumgart J, Dzierzak-Mietla M, Markiewicz M
Lancet Haematol 2020 Jan;7(1):e28-e39. Epub 2019 Oct 9 doi: 10.1016/S2352-3026(19)30157-7. PMID: 31606445
Boddu PC, Zeidan AM
Best Pract Res Clin Haematol 2019 Mar;32(1):74-88. Epub 2019 Feb 7 doi: 10.1016/j.beha.2019.02.002. PMID: 30927978Free PMC Article
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article

Diagnosis

Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Larson RA
Best Pract Res Clin Haematol 2007 Mar;20(1):29-37. doi: 10.1016/j.beha.2006.10.006. PMID: 17336252
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S
J Clin Oncol 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. PMID: 12610191
Giles FJ, Koeffler HP
Curr Opin Hematol 1994 Jul;1(4):256-60. PMID: 9371291

Therapy

Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Beelen DW, Trenschel R, Stelljes M, Groth C, Masszi T, Reményi P, Wagner-Drouet EM, Hauptrock B, Dreger P, Luft T, Bethge W, Vogel W, Ciceri F, Peccatori J, Stölzel F, Schetelig J, Junghanß C, Grosse-Thie C, Michallet M, Labussiere-Wallet H, Schaefer-Eckart K, Dressler S, Grigoleit GU, Mielke S, Scheid C, Holtick U, Patriarca F, Medeot M, Rambaldi A, Micò MC, Niederwieser D, Franke GN, Hilgendorf I, Winkelmann NR, Russo D, Socié G, Peffault de Latour R, Holler E, Wolff D, Glass B, Casper J, Wulf G, Menzel H, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, Grass S, Iori AP, Finke J, Benedetti F, Pichlmeier U, Hemmelmann C, Tribanek M, Klein A, Mylius HA, Baumgart J, Dzierzak-Mietla M, Markiewicz M
Lancet Haematol 2020 Jan;7(1):e28-e39. Epub 2019 Oct 9 doi: 10.1016/S2352-3026(19)30157-7. PMID: 31606445
Boddu PC, Zeidan AM
Best Pract Res Clin Haematol 2019 Mar;32(1):74-88. Epub 2019 Feb 7 doi: 10.1016/j.beha.2019.02.002. PMID: 30927978Free PMC Article
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article
Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick ED, Fernandez HF, Alyea EP, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Le-Rademacher J, Mendizabal AM, Horowitz MM, Deeg HJ, Horwitz ME
J Clin Oncol 2017 Apr 10;35(11):1154-1161. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7091. PMID: 28380315Free PMC Article

Prognosis

Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article
Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick ED, Fernandez HF, Alyea EP, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Le-Rademacher J, Mendizabal AM, Horowitz MM, Deeg HJ, Horwitz ME
J Clin Oncol 2017 Apr 10;35(11):1154-1161. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7091. PMID: 28380315Free PMC Article
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article

Clinical prediction guides

Boddu PC, Zeidan AM
Best Pract Res Clin Haematol 2019 Mar;32(1):74-88. Epub 2019 Feb 7 doi: 10.1016/j.beha.2019.02.002. PMID: 30927978Free PMC Article
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article
Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH
Leukemia 2008 Feb;22(2):240-8. Epub 2008 Jan 17 doi: 10.1038/sj.leu.2405078. PMID: 18200041
Giles FJ, Koeffler HP
Curr Opin Hematol 1994 Jul;1(4):256-60. PMID: 9371291

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