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Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

MedGen UID:
233970
•Concept ID:
C1332234
•
Neoplastic Process
Synonyms: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent; acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent; Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; AML and myelodysplastic syndromes related to alkylating agent
SNOMED CT: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent (766045006)
 
Monarch Initiative: MONDO:0015164
Orphanet: ORPHA102379

Definition

A subgroup of therapy-related myeloid neoplasms (t-MN), associated with a treatment of an unrelated neoplastic or autoimmune disease with cytotoxic agents, like cyclophosphamid, platins, melphalan and others. The neoplastic cells typically harbour unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. It usually presents with multilineage dysplasia and cytopenias 5-10 years after exposure, with symptoms related to the degree of bone marrow failure and the corresponding cytopenia (fatigue, bleeding and bruising, recurrent infections, bone pain). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

Professional guidelines

PubMed

Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Treatment-related myelodysplasia and acute leukemia in non-Hodgkin's lymphoma patients.
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S
J Clin Oncol 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. PMID: 12610191
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial.
Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial.
Beelen DW, Trenschel R, Stelljes M, Groth C, Masszi T, Reményi P, Wagner-Drouet EM, Hauptrock B, Dreger P, Luft T, Bethge W, Vogel W, Ciceri F, Peccatori J, Stölzel F, Schetelig J, Junghanß C, Grosse-Thie C, Michallet M, Labussiere-Wallet H, Schaefer-Eckart K, Dressler S, Grigoleit GU, Mielke S, Scheid C, Holtick U, Patriarca F, Medeot M, Rambaldi A, Micò MC, Niederwieser D, Franke GN, Hilgendorf I, Winkelmann NR, Russo D, Socié G, Peffault de Latour R, Holler E, Wolff D, Glass B, Casper J, Wulf G, Menzel H, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, Grass S, Iori AP, Finke J, Benedetti F, Pichlmeier U, Hemmelmann C, Tribanek M, Klein A, Mylius HA, Baumgart J, Dzierzak-Mietla M, Markiewicz M
Lancet Haematol 2020 Jan;7(1):e28-e39. Epub 2019 Oct 9 doi: 10.1016/S2352-3026(19)30157-7. PMID: 31606445
Myeloid disorders after autoimmune disease.
Boddu PC, Zeidan AM
Best Pract Res Clin Haematol 2019 Mar;32(1):74-88. Epub 2019 Feb 7 doi: 10.1016/j.beha.2019.02.002. PMID: 30927978Free PMC Article
Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Therapy-related myeloid neoplasms: when genetics and environment collide.
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article

Diagnosis

Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Treatment-related myelodysplasia and acute leukemia in non-Hodgkin's lymphoma patients.
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S
J Clin Oncol 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. PMID: 12610191
Secondary myelodysplastic syndromes and leukemias.
Giles FJ, Koeffler HP
Curr Opin Hematol 1994 Jul;1(4):256-60. PMID: 9371291

Therapy

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial.
Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial.
Beelen DW, Trenschel R, Stelljes M, Groth C, Masszi T, Reményi P, Wagner-Drouet EM, Hauptrock B, Dreger P, Luft T, Bethge W, Vogel W, Ciceri F, Peccatori J, Stölzel F, Schetelig J, Junghanß C, Grosse-Thie C, Michallet M, Labussiere-Wallet H, Schaefer-Eckart K, Dressler S, Grigoleit GU, Mielke S, Scheid C, Holtick U, Patriarca F, Medeot M, Rambaldi A, Micò MC, Niederwieser D, Franke GN, Hilgendorf I, Winkelmann NR, Russo D, Socié G, Peffault de Latour R, Holler E, Wolff D, Glass B, Casper J, Wulf G, Menzel H, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, Grass S, Iori AP, Finke J, Benedetti F, Pichlmeier U, Hemmelmann C, Tribanek M, Klein A, Mylius HA, Baumgart J, Dzierzak-Mietla M, Markiewicz M
Lancet Haematol 2020 Jan;7(1):e28-e39. Epub 2019 Oct 9 doi: 10.1016/S2352-3026(19)30157-7. PMID: 31606445
Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Therapy-related myeloid neoplasms: when genetics and environment collide.
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick ED, Fernandez HF, Alyea EP, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Le-Rademacher J, Mendizabal AM, Horowitz MM, Deeg HJ, Horwitz ME
J Clin Oncol 2017 Apr 10;35(11):1154-1161. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7091. PMID: 28380315Free PMC Article

Prognosis

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial.
Geyer CE, Sikov WM, Huober J, Rugo HS, Wolmark N, O'Shaughnessy J, Maag D, Untch M, Golshan M, Lorenzo JP, Metzger O, Dunbar M, Symmans WF, Rastogi P, Sohn JH, Young R, Wright GS, Harkness C, McIntyre K, Yardley D, Loibl S
Ann Oncol 2022 Apr;33(4):384-394. Epub 2022 Jan 31 doi: 10.1016/j.annonc.2022.01.009. PMID: 35093516
Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Therapy-related myeloid neoplasms: when genetics and environment collide.
McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Scott BL, Pasquini MC, Logan BR, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick ED, Fernandez HF, Alyea EP, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Le-Rademacher J, Mendizabal AM, Horowitz MM, Deeg HJ, Horwitz ME
J Clin Oncol 2017 Apr 10;35(11):1154-1161. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7091. PMID: 28380315Free PMC Article
Therapy-related myeloid neoplasms: pathobiology and clinical characteristics.
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article

Clinical prediction guides

Myeloid disorders after autoimmune disease.
Boddu PC, Zeidan AM
Best Pract Res Clin Haematol 2019 Mar;32(1):74-88. Epub 2019 Feb 7 doi: 10.1016/j.beha.2019.02.002. PMID: 30927978Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Therapy-related myeloid neoplasms: pathobiology and clinical characteristics.
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article
Genetics of therapy-related myelodysplasia and acute myeloid leukemia.
Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH
Leukemia 2008 Feb;22(2):240-8. Epub 2008 Jan 17 doi: 10.1038/sj.leu.2405078. PMID: 18200041
Secondary myelodysplastic syndromes and leukemias.
Giles FJ, Koeffler HP
Curr Opin Hematol 1994 Jul;1(4):256-60. PMID: 9371291

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