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Anal Canal Intraepithelial Neoplasia

MedGen UID:
233978
Concept ID:
C1332260
Neoplastic Process
Synonyms: Anal Canal Dysplasia; Anal Canal Squamous Dysplasia; Anal Canal Squamous Intraepithelial Neoplasia; Anal Squamous Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process involving the anal canal. When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules. Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures. It may be classified as low or high grade. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Roelandt P, De Looze D, De Schepper H, Ledouble V, Surmont M, Cuming T
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):625-631. doi: 10.51821/85.4.10820. PMID: 36566372
Knight K, Al-Wahid M, Choong JX, Burton K, Lindsay R, McKee RF, Anderson JH, Roxburgh CS
Eur J Surg Oncol 2021 Feb;47(2):304-310. Epub 2020 Aug 19 doi: 10.1016/j.ejso.2020.08.011. PMID: 32873453

Recent clinical studies

Etiology

Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, Barton SE, Bower M
AIDS 2010 Sep 24;24(15):2331-5. doi: 10.1097/QAD.0b013e32833d466c. PMID: 20729710

Diagnosis

Fenger C, Nielsen VT
Acta Pathol Microbiol Immunol Scand A 1986 Sep;94(5):343-9. doi: 10.1111/j.1699-0463.1986.tb03003.x. PMID: 3766143

Therapy

Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, Barton SE, Bower M
AIDS 2010 Sep 24;24(15):2331-5. doi: 10.1097/QAD.0b013e32833d466c. PMID: 20729710

Recent systematic reviews

Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article

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