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Bone Schwannoma

MedGen UID:
234024
•Concept ID:
C1332476
•
Neoplastic Process
Synonyms: Benign Bone Neurilemmoma; Benign Bone Schwannoma; Benign Neurilemmoma of Bone; Benign Neurilemmoma of the Bone; Benign Schwannoma of Bone; Benign Schwannoma of the Bone

Definition

A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Schwannoma

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Orbital Schwannoma-Management and Clinical Outcomes.
Yong KL, Beckman TJ, Cranstoun M, Sullivan TJ
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):590-595. doi: 10.1097/IOP.0000000000001657. PMID: 32282644
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649

Recent clinical studies

Etiology

Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
Primary Benign Tumors of the Spinal Canal.
Carlos-Escalante JA, Paz-López ÁA, Cacho-Díaz B, Pacheco-Cuellar G, Reyes-Soto G, Wegman-Ostrosky T
World Neurosurg 2022 Aug;164:178-198. Epub 2022 May 10 doi: 10.1016/j.wneu.2022.04.135. PMID: 35552036
Orbital Schwannoma-Management and Clinical Outcomes.
Yong KL, Beckman TJ, Cranstoun M, Sullivan TJ
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):590-595. doi: 10.1097/IOP.0000000000001657. PMID: 32282644
Surgery of the lateral skull base: a 50-year endeavour.
Zanoletti E, Mazzoni A, Martini A, Abbritti RV, Albertini R, Alexandre E, Baro V, Bartolini S, Bernardeschi D, Bivona R, Bonali M, Borghesi I, Borsetto D, Bovo R, Breun M, Calbucci F, Carlson ML, Caruso A, Cayé-Thomasen P, Cazzador D, Champagne PO, Colangeli R, Conte G, D'Avella D, Danesi G, Deantonio L, Denaro L, Di Berardino F, Draghi R, Ebner FH, Favaretto N, Ferri G, Fioravanti A, Froelich S, Giannuzzi A, Girasoli L, Grossardt BR, Guidi M, Hagen R, Hanakita S, Hardy DG, Iglesias VC, Jefferies S, Jia H, Kalamarides M, Kanaan IN, Krengli M, Landi A, Lauda L, Lepera D, Lieber S, Lloyd SLK, Lovato A, Maccarrone F, Macfarlane R, Magnan J, Magnoni L, Marchioni D, Marinelli JP, Marioni G, Mastronardi V, Matthies C, Moffat DA, Munari S, Nardone M, Pareschi R, Pavone C, Piccirillo E, Piras G, Presutti L, Restivo G, Reznitsky M, Roca E, Russo A, Sanna M, Sartori L, Scheich M, Shehata-Dieler W, Soloperto D, Sorrentino F, Sterkers O, Taibah A, Tatagiba M, Tealdo G, Vlad D, Wu H, Zanetti D
Acta Otorhinolaryngol Ital 2019 Jun;39(SUPPL. 1):S1-S146. doi: 10.14639/0392-100X-suppl.1-39-2019. PMID: 31130732Free PMC Article
Intracranial Melanotic Schwannomas.
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291

Diagnosis

Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
Orbital Schwannoma-Management and Clinical Outcomes.
Yong KL, Beckman TJ, Cranstoun M, Sullivan TJ
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):590-595. doi: 10.1097/IOP.0000000000001657. PMID: 32282644
Orbital Frontal Nerve Schwannoma-Distinctive Radiological Features.
Young SM, Kim YD, Jeon GS, Woo KI
Am J Ophthalmol 2018 Feb;186:41-46. Epub 2017 Dec 2 doi: 10.1016/j.ajo.2017.11.012. PMID: 29197538
Intracranial Melanotic Schwannomas.
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291
Olfactory schwannoma.
Amador AR, Santonja C, Del Pozo JM, Ortiz L
Eur Radiol 2002 Apr;12(4):742-4. Epub 2001 Dec 18 doi: 10.1007/s003300101059. PMID: 11960220

Therapy

Comprehensive review of the extended middle cranial fossa approach.
Lipschitz N, Kohlberg GD, Zuccarello M, Samy RN
Curr Opin Otolaryngol Head Neck Surg 2018 Oct;26(5):286-292. doi: 10.1097/MOO.0000000000000471. PMID: 29957681
Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial.
Gronchi A, Ferrari S, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Basso U, Blay JY, Tendero O, Beveridge RD, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Palmerini E, De Sanctis R, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG
Lancet Oncol 2017 Jun;18(6):812-822. Epub 2017 May 9 doi: 10.1016/S1470-2045(17)30334-0. PMID: 28499583
Habilitation of auditory and vestibular dysfunction.
Snapp HA, Schubert MC
Otolaryngol Clin North Am 2012 Apr;45(2):487-511, x-xi. doi: 10.1016/j.otc.2011.12.014. PMID: 22483829
Middle fossa approach: indications, technique, and results.
Angeli S
Otolaryngol Clin North Am 2012 Apr;45(2):417-38, ix. doi: 10.1016/j.otc.2011.12.010. PMID: 22483825
The value of adjuvant chemotherapy in the management of sarcomas in children.
Donaldson SS
Cancer 1985 May 1;55(9 Suppl):2184-97. doi: 10.1002/1097-0142(19850501)55:9+<2184::aid-cncr2820551422>3.0.co;2-n. PMID: 3884137

Prognosis

Dural-based lesions: is it a meningioma?
Nagai Yamaki V, de Souza Godoy LF, Alencar Bandeira G, Tavares Lucato L, Correa Lordelo G, Fontoura Solla DJ, Santana Neville I, Jacobsen Teixeira M, Silva Paiva W
Neuroradiology 2021 Aug;63(8):1215-1225. Epub 2021 Jan 18 doi: 10.1007/s00234-021-02632-y. PMID: 33459822
Imaging of the temporal bone.
Touska P, Connor SEJ
Clin Radiol 2020 Sep;75(9):658-674. Epub 2020 Jul 18 doi: 10.1016/j.crad.2020.06.013. PMID: 32690241
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Intracranial Melanotic Schwannomas.
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Clinical prediction guides

Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
The trigeminal nerve.
Nemzek WR
Top Magn Reson Imaging 1996 Jun;8(3):132-54. PMID: 8840469

Recent systematic reviews

Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part III: Lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII).
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT, Froelich S, Jouanneau E, Meling TR, Messerer M, Roche PH, Schroeder H, Tatagiba M, Zazpe I, Paraskevopoulos D
Acta Neurochir (Wien) 2022 Feb;164(2):321-329. Epub 2021 Dec 2 doi: 10.1007/s00701-021-05072-y. PMID: 34854994
Comparison of translabyrinthine and retrosigmoid approach for treating vestibular schwannoma: A meta-analysis.
Jun W, Gao YL, Yu HG, Huang QL, Long XQ, Liu GH, Ting X, Zhong XY, Zhou YF
Clin Neurol Neurosurg 2020 Sep;196:105994. Epub 2020 Jun 6 doi: 10.1016/j.clineuro.2020.105994. PMID: 32540713
Surgical Management of Mandibular Intraosseous Schwannomas.
DeLeonibus A, Bassiri Gharb B, Papay F, Zins JE, Rampazzo A
J Craniofac Surg 2017 Jun;28(4):e307-e311. doi: 10.1097/SCS.0000000000003557. PMID: 28212127
Schwannomas of the sinonasal tract and anterior skull base: a systematic review of 94 cases.
Sunaryo PL, Svider PF, Husain Q, Choudhry OJ, Eloy JA, Liu JK
Am J Rhinol Allergy 2014 Jan-Feb;28(1):39-49. doi: 10.2500/ajra.2014.28.3978. PMID: 24717879
Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.
Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468

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