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Extrahepatic Bile Duct Benign Granular Cell Tumor

MedGen UID:
234028
•Concept ID:
C1332507
•
Neoplastic Process
Synonyms: Benign Extrahepatic Bile Duct Granular Cell Myoblastoma; Benign Granular Cell Myoblastoma of Extrahepatic Bile Duct; Benign Granular Cell Myoblastoma of the Extrahepatic Bile Duct; Benign Granular Cell Tumor of Extrahepatic Bile Ducts

Definition

A granular cell tumor that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Benign Granular Cell Tumor

Professional guidelines

PubMed

Management of carcinoma of the extrahepatic bile ducts.
Black K, Hanna SS, Langer B, Jirsch DW, Rider WD
Can J Surg 1978 Nov;21(6):542-5. PMID: 83901

Recent clinical studies

Etiology

Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas.
Stretch C, Aubin JM, Mickiewicz B, Leugner D, Al-Manasra T, Tobola E, Salazar S, Sutherland FR, Ball CG, Dixon E, Vogel HJ, Damaraju S, Baracos VE, Bathe OF
PLoS One 2018;13(5):e0196235. Epub 2018 May 3 doi: 10.1371/journal.pone.0196235. PMID: 29723245Free PMC Article
Granular cell tumor of the intrapancreatic common bile duct: one case report and review of the literature.
Altavilla G, Brotto M, Busatto G, Boccù C, Ragni L
Ultrastruct Pathol 2004 May-Jun;28(3):171-6. doi: 10.1080/01913120490475752. PMID: 15471431
Pancreas-sparing duodenectomy: classification, indication and procedures.
Nagai H, Hyodo M, Kurihara K, Ohki J, Yasuda T, Kasahara K, Sekiguchi C, Kanazawa K
Hepatogastroenterology 1999 May-Jun;46(27):1953-8. PMID: 10430376
Biliary duct granular cell tumor: a rare but surgically curable benign tumor.
Lewis WD, Buell JF, Jenkins RL, Burke PA
HPB Surg 1993 Aug;6(4):311-7. doi: 10.1155/1993/68037. PMID: 8217927Free PMC Article
Granular cell tumor of the biliary tree. A report of two cases and a review of the literature.
Eisen RN, Kirby WM, O'Quinn JL
Am J Surg Pathol 1991 May;15(5):460-5. doi: 10.1097/00000478-199105000-00006. PMID: 1852131

Diagnosis

Extrahepatic obstructive jaundice due to granular cell tumour: Importance and uniqueness of preoperative diagnosis.
Lama C, Parada C, Alonso S
Gastroenterol Hepatol 2022 Apr;45 Suppl 1:45-46. Epub 2021 Aug 13 doi: 10.1016/j.gastrohep.2021.07.008. PMID: 34400192
Granular cell tumor of the common bile duct: a Japanese case.
Saito J, Kitagawa M, Kusanagi H, Kano N, Ishii E, Nakaji S, Hirata N, Hoshi K
World J Gastroenterol 2012 Nov 21;18(43):6324-7. doi: 10.3748/wjg.v18.i43.6324. PMID: 23180955Free PMC Article
Granular cell tumor of the intrapancreatic common bile duct: one case report and review of the literature.
Altavilla G, Brotto M, Busatto G, Boccù C, Ragni L
Ultrastruct Pathol 2004 May-Jun;28(3):171-6. doi: 10.1080/01913120490475752. PMID: 15471431
Granular cell tumor at the hepatic duct confluence mimicking Klatskin tumor. A report of two cases and a review of the literature.
te Boekhorst DS, Gerhards MF, van Gulik TM, Gouma DJ
Dig Surg 2000;17(3):299-303. doi: 10.1159/000018858. PMID: 10867472
Granular cell tumor of the common bile duct.
Manstein ME, McBrearty FX, Pellechia PE, Paskin DL
Dig Dis Sci 1981 Oct;26(10):938-42. doi: 10.1007/BF01309501. PMID: 7285736

Therapy

Myosteatosis predicts survival after surgery for periampullary cancer: a novel method using MRI.
van Dijk DPJ, Bakers FCH, Sanduleanu S, Vaes RDW, Rensen SS, Dejong CHC, Beets-Tan RGH, Olde Damink SWM
HPB (Oxford) 2018 Aug;20(8):715-720. Epub 2018 Mar 5 doi: 10.1016/j.hpb.2018.02.378. PMID: 29519644
Impact of the preoperative quantity and quality of skeletal muscle on outcomes after resection of extrahepatic biliary malignancies.
Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Kobayashi A, Iida T, Yagi S, Taura K, Hatano E, Uemoto S
Surgery 2016 Mar;159(3):821-33. Epub 2015 Oct 23 doi: 10.1016/j.surg.2015.08.047. PMID: 26603849
A child with unresectable biliary rhabdomyosarcoma: 48-month disease-free survival after liver transplantation.
Paganelli M, Beaunoyer M, Samson Y, Dal Soglio D, Dubois J, Lallier M, Alvarez F
Pediatr Transplant 2014 Aug;18(5):E146-51. Epub 2014 May 12 doi: 10.1111/petr.12279. PMID: 24815678
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report.
Zampieri N, Camoglio F, Corroppolo M, Cecchetto M, Ornis S, Ottolenghi A
Eur J Cancer Care (Engl) 2006 Dec;15(5):463-6. doi: 10.1111/j.1365-2354.2006.00683.x. PMID: 17177904
Benign tumors and pseudotumors of the gallbladder. Report of 180 cases.
Christensen AH, Ishak KG
Arch Pathol 1970 Nov;90(5):423-32. PMID: 4319984

Prognosis

Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients.
Hong SM, Kim MJ, Pi DY, Jo D, Cho HJ, Yu E, Ro JY
Cancer 2005 Aug 15;104(4):802-10. doi: 10.1002/cncr.21236. PMID: 15959914
Granular cell tumor of the intrapancreatic common bile duct: one case report and review of the literature.
Altavilla G, Brotto M, Busatto G, Boccù C, Ragni L
Ultrastruct Pathol 2004 May-Jun;28(3):171-6. doi: 10.1080/01913120490475752. PMID: 15471431
Granular cell tumor at the hepatic duct confluence mimicking Klatskin tumor. A report of two cases and a review of the literature.
te Boekhorst DS, Gerhards MF, van Gulik TM, Gouma DJ
Dig Surg 2000;17(3):299-303. doi: 10.1159/000018858. PMID: 10867472
Biliary duct granular cell tumor: a rare but surgically curable benign tumor.
Lewis WD, Buell JF, Jenkins RL, Burke PA
HPB Surg 1993 Aug;6(4):311-7. doi: 10.1155/1993/68037. PMID: 8217927Free PMC Article
Biliary granular cell tumor: a little-known curable bile duct neoplasm of young people.
Butterly LF, Schapiro RH, LaMuraglia GM, Warshaw AL
Surgery 1988 Mar;103(3):328-34. PMID: 2830680

Clinical prediction guides

Myosteatosis predicts survival after surgery for periampullary cancer: a novel method using MRI.
van Dijk DPJ, Bakers FCH, Sanduleanu S, Vaes RDW, Rensen SS, Dejong CHC, Beets-Tan RGH, Olde Damink SWM
HPB (Oxford) 2018 Aug;20(8):715-720. Epub 2018 Mar 5 doi: 10.1016/j.hpb.2018.02.378. PMID: 29519644
Impact of the preoperative quantity and quality of skeletal muscle on outcomes after resection of extrahepatic biliary malignancies.
Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Kobayashi A, Iida T, Yagi S, Taura K, Hatano E, Uemoto S
Surgery 2016 Mar;159(3):821-33. Epub 2015 Oct 23 doi: 10.1016/j.surg.2015.08.047. PMID: 26603849
Granular cell tumor of the intrapancreatic common bile duct: one case report and review of the literature.
Altavilla G, Brotto M, Busatto G, Boccù C, Ragni L
Ultrastruct Pathol 2004 May-Jun;28(3):171-6. doi: 10.1080/01913120490475752. PMID: 15471431
Periampullary tumors: high-spatial-resolution MR imaging and histopathologic findings in ampullary region specimens.
Sugita R, Furuta A, Ito K, Fujita N, Ichinohasama R, Takahashi S
Radiology 2004 Jun;231(3):767-74. Epub 2004 Apr 22 doi: 10.1148/radiol.2313030797. PMID: 15105450
Frozen section diagnosis of pancreatic carcinoma: a prospective study of 64 biopsies.
Hyland C, Kheir SM, Kashlan MB
Am J Surg Pathol 1981 Mar;5(2):179-91. doi: 10.1097/00000478-198103000-00007. PMID: 7223929

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