U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bone leiomyosarcoma

MedGen UID:
234043
•Concept ID:
C1332579
•
Neoplastic Process
Synonyms: Bone Leiomyosarcoma; bone leiomyosarcoma; bone tissue leiomyosarcoma; Leiomyosarcoma of Bone; leiomyosarcoma of bone; leiomyosarcoma of bone tissue
 
Monarch Initiative: MONDO:0002624

Definition

A rare aggressive malignant smooth muscle neoplasm, arising from the bone. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone leiomyosarcoma

Professional guidelines

PubMed

Presentation, Management, and Outcome of Primary Leiomyosarcoma of the Spine: A Systematic Review.
Townsend DC, Purohit N, Giannoulis K, Shtaya A
World Neurosurg 2022 Jul;163:25-35. Epub 2022 Apr 5 doi: 10.1016/j.wneu.2022.03.138. PMID: 35390494
Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first-line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.
D'Ambrosio L, Touati N, Blay JY, Grignani G, Flippot R, Czarnecka AM, Piperno-Neumann S, Martin-Broto J, Sanfilippo R, Katz D, Duffaud F, Vincenzi B, Stark DP, Mazzeo F, Tuchscherer A, Chevreau C, Sherriff J, Estival A, Litière S, Sents W, Ray-Coquard I, Tolomeo F, Le Cesne A, Rutkowski P, Stacchiotti S, Kasper B, Gelderblom H, Gronchi A; European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Cancer 2020 Jun 1;126(11):2637-2647. Epub 2020 Mar 4 doi: 10.1002/cncr.32795. PMID: 32129883
Efficacy of trabectedin for the treatment of liposarcoma.
Zijoo R, von Mehren M
Expert Opin Pharmacother 2016 Oct;17(14):1953-62. Epub 2016 Sep 15 doi: 10.1080/14656566.2016.1229304. PMID: 27615729

Recent clinical studies

Etiology

Subperiosteal leiomyosarcoma of the tibia.
Narváez JA, De Lama E, Portabella F, Ortega R, Condom E
Skeletal Radiol 2005 Jan;34(1):42-6. Epub 2004 Oct 2 doi: 10.1007/s00256-004-0838-y. PMID: 15635482

Diagnosis

Primary bone leiomyosarcoma of distal femur: case report and literature review.
Georgeanu VA, Pletosu RI, Vlădescu TC, Bondari S, Crăciunescu A, Russu OM
Rom J Morphol Embryol 2022 Jul-Sep;63(3):569-574. doi: 10.47162/RJME.63.3.12. PMID: 36588496Free PMC Article
Choroidal metastasis from primary bone leiomyosarcoma.
Cristina NG, Francisco ED, Vanesa RG, Fernando CG, Luis CM, Emiliano HG
Int Ophthalmol 2015 Oct;35(5):721-5. Epub 2015 Jun 25 doi: 10.1007/s10792-015-0096-0. PMID: 26109142
Including MIR of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor.
Sirikulchayanonta V, Jaovisidh S
J Med Assoc Thai 2008 Feb;91(2):244-8. PMID: 18389991
Subperiosteal leiomyosarcoma of the tibia.
Narváez JA, De Lama E, Portabella F, Ortega R, Condom E
Skeletal Radiol 2005 Jan;34(1):42-6. Epub 2004 Oct 2 doi: 10.1007/s00256-004-0838-y. PMID: 15635482

Prognosis

Lower gastrointestinal bleeding due to small bowel metastasis from leiomyosarcoma in the tibia.
Chiang KC, Yeh CN, Shih HN, Jan YY, Chen MF
Chang Gung Med J 2006 Jul-Aug;29(4):430-4. PMID: 17051843
Subperiosteal leiomyosarcoma of the tibia.
Narváez JA, De Lama E, Portabella F, Ortega R, Condom E
Skeletal Radiol 2005 Jan;34(1):42-6. Epub 2004 Oct 2 doi: 10.1007/s00256-004-0838-y. PMID: 15635482

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...