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Childhood Diffuse Large B-Cell Lymphoma

MedGen UID:
234127
•Concept ID:
C1332967
•
Neoplastic Process
Synonym: Pediatric Diffuse Large B Cell Lymphoma

Definition

A diffuse large B-cell lymphoma that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study.
Yasuda T, Sanada M, Nishijima D, Kanamori T, Iijima Y, Hattori H, Saito A, Miyoshi H, Ishikawa Y, Asou N, Usuki K, Hirabayashi S, Kato M, Ri M, Handa H, Ishida T, Shibayama H, Abe M, Iriyama C, Karube K, Nishikori M, Ohshima K, Kataoka K, Yoshida K, Shiraishi Y, Goto H, Adachi S, Kobayashi R, Kiyoi H, Miyazaki Y, Ogawa S, Kurahashi H, Yokoyama H, Manabe A, Iida S, Tomita A, Horibe K
Cancer Sci 2020 Sep;111(9):3367-3378. Epub 2020 Jul 17 doi: 10.1111/cas.14552. PMID: 32619037Free PMC Article
Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma.
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481
Treatment of Burkitt lymphoma in children and adults: Lessons from Africa.
Magrath IT
Curr Hematol Malig Rep 2006 Dec;1(4):230-40. doi: 10.1007/s11899-006-0004-9. PMID: 20425318

Recent clinical studies

Etiology

Cutaneous EBV-related lymphoproliferative disorders.
Gru AA, Jaffe ES
Semin Diagn Pathol 2017 Jan;34(1):60-75. Epub 2016 Dec 7 doi: 10.1053/j.semdp.2016.11.003. PMID: 27988064Free PMC Article
Non-Hodgkin Lymphoma in Children.
Sandlund JT
Curr Hematol Malig Rep 2015 Sep;10(3):237-43. doi: 10.1007/s11899-015-0277-y. PMID: 26174528
CNS prophylaxis in diffuse large B-cell lymphoma: if, when, how and for whom?
Siegal T, Goldschmidt N
Blood Rev 2012 May;26(3):97-106. Epub 2012 Jan 13 doi: 10.1016/j.blre.2011.12.001. PMID: 22244544
Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: state of the science.
Hochberg J, Waxman IM, Kelly KM, Morris E, Cairo MS
Br J Haematol 2009 Jan;144(1):24-40. doi: 10.1111/j.1365-2141.2008.07393.x. PMID: 19087093
Recent advances in the understanding and management of diffuse large B-cell lymphoma in children.
Reiter A, Klapper W
Br J Haematol 2008 Jul;142(3):329-47. Epub 2008 Jun 3 doi: 10.1111/j.1365-2141.2008.06988.x. PMID: 18537979

Diagnosis

Non-Hodgkin Lymphoma in Children.
Sandlund JT
Curr Hematol Malig Rep 2015 Sep;10(3):237-43. doi: 10.1007/s11899-015-0277-y. PMID: 26174528
Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma.
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481
Pediatric lymphomas and histiocytic disorders of childhood.
Allen CE, Kelly KM, Bollard CM
Pediatr Clin North Am 2015 Feb;62(1):139-65. doi: 10.1016/j.pcl.2014.09.010. PMID: 25435117Free PMC Article
CNS prophylaxis in diffuse large B-cell lymphoma: if, when, how and for whom?
Siegal T, Goldschmidt N
Blood Rev 2012 May;26(3):97-106. Epub 2012 Jan 13 doi: 10.1016/j.blre.2011.12.001. PMID: 22244544
Recent advances in the understanding and management of diffuse large B-cell lymphoma in children.
Reiter A, Klapper W
Br J Haematol 2008 Jul;142(3):329-47. Epub 2008 Jun 3 doi: 10.1111/j.1365-2141.2008.06988.x. PMID: 18537979

Therapy

Tisagenlecleucel immunogenicity in relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
Thudium Mueller K, Grupp SA, Maude SL, Levine JE, Pulsipher MA, Boyer MW, August KJ, Myers GD, Tam CS, Jaeger U, Foley SR, Borchmann P, Schuster SJ, Waller EK, Awasthi R, Potthoff B, Warren A, Waldron ER, McBlane F, Chassot-Agostinho A, Laetsch TW
Blood Adv 2021 Dec 14;5(23):4980-4991. doi: 10.1182/bloodadvances.2020003844. PMID: 34432863Free PMC Article
Childhood de novo CD5+ Diffuse Large B-cell Lymphoma: a Separate Entity?
Coffey A, Allen A, Thomsen MB, Sulis ML, Murty V, Hoehn D
Ann Clin Lab Sci 2015 Fall;45(5):574-81. PMID: 26586711
Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma.
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481
CNS prophylaxis in diffuse large B-cell lymphoma: if, when, how and for whom?
Siegal T, Goldschmidt N
Blood Rev 2012 May;26(3):97-106. Epub 2012 Jan 13 doi: 10.1016/j.blre.2011.12.001. PMID: 22244544
Recent advances in the understanding and management of diffuse large B-cell lymphoma in children.
Reiter A, Klapper W
Br J Haematol 2008 Jul;142(3):329-47. Epub 2008 Jun 3 doi: 10.1111/j.1365-2141.2008.06988.x. PMID: 18537979

Prognosis

Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom.
Singh A, Obiorah IE
Semin Diagn Pathol 2023 Nov;40(6):392-400. Epub 2023 Jun 22 doi: 10.1053/j.semdp.2023.06.002. PMID: 37400280
Primary breast lymphoma of childhood: a case report and review of literature.
Restivo GA, Pillon M, Mussolin L, Mosa C, Guarina A, Trizzino A, Ialuna S, Carraro E, D'Amore ESG, Russo G, Elia C, Mascarin M, Zangara A, D'Angelo P, Farruggia P
BMC Pediatr 2021 Nov 30;21(1):530. doi: 10.1186/s12887-021-03002-6. PMID: 34847896Free PMC Article
Childhood de novo CD5+ Diffuse Large B-cell Lymphoma: a Separate Entity?
Coffey A, Allen A, Thomsen MB, Sulis ML, Murty V, Hoehn D
Ann Clin Lab Sci 2015 Fall;45(5):574-81. PMID: 26586711
Non-Hodgkin Lymphoma in Children.
Sandlund JT
Curr Hematol Malig Rep 2015 Sep;10(3):237-43. doi: 10.1007/s11899-015-0277-y. PMID: 26174528
Childhood and adolescent large-cell lymphoma (LCL): a review of the Children's Cancer Group experience.
Cairo MS, Sposto R, Hoover-Regan M, Meadows AT, Anderson JR, Siegel SE, Kadin ME, Kjeldsberg CR, Wilson JF, Perkins SL, Lones MA, Morris E, Finlay JL
Am J Hematol 2003 Jan;72(1):53-63. doi: 10.1002/ajh.10262. PMID: 12508269

Clinical prediction guides

Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).
Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257
Antitumorigenic action of nelfinavir: Effects on multiple myeloma and hematologic malignancies (Review).
Allegra A, Innao V, Allegra AG, Pulvirenti N, Pugliese M, Musolino C
Oncol Rep 2020 Jun;43(6):1729-1736. Epub 2020 Mar 26 doi: 10.3892/or.2020.7562. PMID: 32236596
Non-Hodgkin's lymphoma by immunohistochemistry.
Akhter A, Saleheen MS, Hussain M, Majid N, Rahman MR, Shermin S, Rajib RC, Huda MM, Haque N
Mymensingh Med J 2015 Jan;24(1):108-14. PMID: 25725676
EBV primary infection in childhood and its relation to B-cell lymphoma development: a mini-review from a developing region.
Chabay PA, Preciado MV
Int J Cancer 2013 Sep 15;133(6):1286-92. Epub 2012 Oct 17 doi: 10.1002/ijc.27858. PMID: 23001576
Childhood and adolescent large-cell lymphoma (LCL): a review of the Children's Cancer Group experience.
Cairo MS, Sposto R, Hoover-Regan M, Meadows AT, Anderson JR, Siegel SE, Kadin ME, Kjeldsberg CR, Wilson JF, Perkins SL, Lones MA, Morris E, Finlay JL
Am J Hematol 2003 Jan;72(1):53-63. doi: 10.1002/ajh.10262. PMID: 12508269

Recent systematic reviews

Body fatness at a young age and risks of eight types of cancer: systematic review and meta-analysis of observational studies.
Hidayat K, Du X, Shi BM
Obes Rev 2018 Oct;19(10):1385-1394. Epub 2018 Jul 25 doi: 10.1111/obr.12705. PMID: 30047231

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