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Conjunctival intraepithelial neoplasm

MedGen UID:
234172
•Concept ID:
C1333148
•
Neoplastic Process
Synonyms: CIN - conjunctival intraepithelial neoplasia; Conjunctiva Intraepithelial Neoplasia; conjunctiva intraepithelial neoplasia; Conjunctival Intraepithelial Neoplasia; Conjunctival intraepithelial neoplasia; conjunctival intraepithelial neoplasia; conjunctival intraepithelial neoplasm; Conjunctival Squamous Intraepithelial Neoplasia; Intraepithelial Neoplasia of Conjunctiva; intraepithelial neoplasia of conjunctiva; Intraepithelial Neoplasia of the Conjunctiva; intraepithelial neoplasia of the conjunctiva
SNOMED CT: Conjunctival intraepithelial neoplasia (418134006); CIN - conjunctival intraepithelial neoplasia (418134006)
 
Monarch Initiative: MONDO:0003453

Definition

A precancerous neoplastic intraepithelial process involving the conjunctival squamous epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival intraepithelial neoplasm

Professional guidelines

PubMed

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Conjunctival Squamous Neoplasia: Staging and Initial Treatment.
Bellerive C, Berry JL, Polski A, Singh AD
Cornea 2018 Oct;37(10):1287-1291. doi: 10.1097/ICO.0000000000001651. PMID: 29863543Free PMC Article
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Recent clinical studies

Etiology

Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.
Hung KH, Hsiao CH, Tan HY, Chen HC, Ma DH, Lin HC, Yeh LK
Int Ophthalmol 2020 Jul;40(7):1781-1788. Epub 2020 Mar 20 doi: 10.1007/s10792-020-01347-y. PMID: 32198608
p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
Kobalka PJ, Abboud JP, Liao X, Jones K, Lee BW, Korn BS, Kikkawa DO, Lin JH
Diagn Pathol 2015 Sep 24;10:175. doi: 10.1186/s13000-015-0396-8. PMID: 26400483Free PMC Article
Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion.
Kuo KT, Chang HC, Hsiao CH, Lin MC
Br J Ophthalmol 2006 Jul;90(7):894-9. Epub 2006 Mar 15 doi: 10.1136/bjo.2005.086314. PMID: 16540490Free PMC Article
Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence.
Chen HC, Chang SW, Huang SF
Cornea 2004 Oct;23(7):726-9. doi: 10.1097/01.ico.0000126320.36014.d1. PMID: 15448502

Diagnosis

p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
Kobalka PJ, Abboud JP, Liao X, Jones K, Lee BW, Korn BS, Kikkawa DO, Lin JH
Diagn Pathol 2015 Sep 24;10:175. doi: 10.1186/s13000-015-0396-8. PMID: 26400483Free PMC Article
Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion.
Kuo KT, Chang HC, Hsiao CH, Lin MC
Br J Ophthalmol 2006 Jul;90(7):894-9. Epub 2006 Mar 15 doi: 10.1136/bjo.2005.086314. PMID: 16540490Free PMC Article

Therapy

Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence.
Chen HC, Chang SW, Huang SF
Cornea 2004 Oct;23(7):726-9. doi: 10.1097/01.ico.0000126320.36014.d1. PMID: 15448502

Prognosis

Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.
Hung KH, Hsiao CH, Tan HY, Chen HC, Ma DH, Lin HC, Yeh LK
Int Ophthalmol 2020 Jul;40(7):1781-1788. Epub 2020 Mar 20 doi: 10.1007/s10792-020-01347-y. PMID: 32198608

Clinical prediction guides

p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
Kobalka PJ, Abboud JP, Liao X, Jones K, Lee BW, Korn BS, Kikkawa DO, Lin JH
Diagn Pathol 2015 Sep 24;10:175. doi: 10.1186/s13000-015-0396-8. PMID: 26400483Free PMC Article

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