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Epithelioid cell uveal melanoma

MedGen UID:: 234223
•Concept ID:: C1333422
•: Neoplastic Process

Synonyms:	epithelioid cell melanoma of uvea; Epithelioid Cell Uveal Melanoma; epithelioid cell uveal melanoma; uvea epithelioid cell melanoma; Uveal Epithelioid Cell Melanoma; uveal epithelioid cell melanoma

Monarch Initiative:	MONDO:0006200

Definition

A uveal melanoma characterized by the presence of malignant large epithelioid melanocytes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEpithelioid cell uveal melanoma

Pathological process
- Disease
  - Neoplasm
    - Malignant neoplastic disease
      - Melanoma
        Epithelioid cell melanoma
        Epithelioid cell uveal melanoma
        Choroid epithelioid cell melanoma
        Ciliary body epithelioid cell melanoma
        Iris Epithelioid Cell Melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.

Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.

Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

Update on the management of posterior uveal melanoma.

Zhao DY, Shields CL, Shields JA, Gunduz K
J Ophthalmic Nurs Technol 1998 Mar-Apr;17(2):66-71. PMID: 9677975

See all (4)

Recent clinical studies

Etiology

Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients.

Lin V, Chung IY, Toumi E, McKay D, McKenzie J, McKelvie P, Zabih F, Hoffmeister A, Wright D, Ntzaferi A, Wu IJ, Hesson L, Fung A, Lim LA, Wong S, Field A, Earls P, Giblin M, Conway RM, Cherepanoff S
Clin Exp Ophthalmol 2022 Jan;50(1):50-61. Epub 2021 Nov 14 doi: 10.1111/ceo.14022. PMID: 34714583

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.

Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

The pathology of ocular cancer.

Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492 Free PMC Article

Uveal tumour resection.

Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967 Free PMC Article

Eye-wall resection.

Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019 Free PMC Article

See all (99)

Diagnosis

Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients.

Epidemiological trends in uveal melanoma.

Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.

Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

Tumours associated with BAP1 mutations.

Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170

See all (54)

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.

Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035 Free PMC Article

Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma.

Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689 Free PMC Article

GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma.

Liu X, Zhang Q, Fan C, Tian J, Liu X, Li G
PLoS One 2019;14(3):e0214073. Epub 2019 Mar 18 doi: 10.1371/journal.pone.0214073. PMID: 30883611 Free PMC Article

Congenital uveal malignant melanoma.

Pukrushpan P, Tulvatana W, Pittayapongpat R
J AAPOS 2014 Apr;18(2):199-201. doi: 10.1016/j.jaapos.2013.11.020. PMID: 24698625

Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.

Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966 Free PMC Article

See all (12)

Prognosis

Incidence and mortality of uveal melanoma in Australia (1982-2014).

Beasley AB, Preen DB, McLenachan S, Gray ES, Chen FK
Br J Ophthalmol 2023 Mar;107(3):406-411. Epub 2021 Dec 8 doi: 10.1136/bjophthalmol-2021-319700. PMID: 34880052 Free PMC Article

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.

Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

Tumours associated with BAP1 mutations.

Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170

The pathology of ocular cancer.

Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492 Free PMC Article

See all (106)

Clinical prediction guides

Characterisation of the protein expression of the emerging immunotherapy targets VISTA, LAG-3 and PRAME in primary uveal melanoma: insights from a southern French patient cohort.

Lamas NJ, Lassalle S, Martel A, Nahon-Estève S, Macocco A, Zahaf K, Lalvee S, Fayada J, Lespinet-Fabre V, Bordone O, Pedeutour F, Baillif S, Hofman P
Pathology 2023 Dec;55(7):929-944. Epub 2023 Sep 22 doi: 10.1016/j.pathol.2023.08.003. PMID: 37863710

Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis.

Marin Lovrić J, Filipović N, Znaor L, Rančić A, Petričević J, Kunac N, Šoljić V, Saraga-Babić M, Vukojević K
Int J Mol Sci 2022 Aug 20;23(16) doi: 10.3390/ijms23169421. PMID: 36012688 Free PMC Article

Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma.

Kashyap S, Singh MK, Jha J, Singh L, Pushker N, Sen S, Venkatesh P, Meel R, Lomi N
Hum Cell 2020 Oct;33(4):1264-1272. Epub 2020 Jul 19 doi: 10.1007/s13577-020-00397-9. PMID: 32686068

Epidemiological trends in uveal melanoma.

Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

See all (75)