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Epithelioid cell uveal melanoma

MedGen UID:
234223
•Concept ID:
C1333422
•
Neoplastic Process
Synonyms: epithelioid cell melanoma of uvea; Epithelioid Cell Uveal Melanoma; epithelioid cell uveal melanoma; uvea epithelioid cell melanoma; Uveal Epithelioid Cell Melanoma; uveal epithelioid cell melanoma
 
Monarch Initiative: MONDO:0006200

Definition

A uveal melanoma characterized by the presence of malignant large epithelioid melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid cell uveal melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Update on the management of posterior uveal melanoma.
Zhao DY, Shields CL, Shields JA, Gunduz K
J Ophthalmic Nurs Technol 1998 Mar-Apr;17(2):66-71. PMID: 9677975

Recent clinical studies

Etiology

Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients.
Lin V, Chung IY, Toumi E, McKay D, McKenzie J, McKelvie P, Zabih F, Hoffmeister A, Wright D, Ntzaferi A, Wu IJ, Hesson L, Fung A, Lim LA, Wong S, Field A, Earls P, Giblin M, Conway RM, Cherepanoff S
Clin Exp Ophthalmol 2022 Jan;50(1):50-61. Epub 2021 Nov 14 doi: 10.1111/ceo.14022. PMID: 34714583
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma.
Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689Free PMC Article
GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma.
Liu X, Zhang Q, Fan C, Tian J, Liu X, Li G
PLoS One 2019;14(3):e0214073. Epub 2019 Mar 18 doi: 10.1371/journal.pone.0214073. PMID: 30883611Free PMC Article
Congenital uveal malignant melanoma.
Pukrushpan P, Tulvatana W, Pittayapongpat R
J AAPOS 2014 Apr;18(2):199-201. doi: 10.1016/j.jaapos.2013.11.020. PMID: 24698625
Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.
Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966Free PMC Article

Prognosis

Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article

Clinical prediction guides

Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis.
Marin Lovrić J, Filipović N, Znaor L, Rančić A, Petričević J, Kunac N, Šoljić V, Saraga-Babić M, Vukojević K
Int J Mol Sci 2022 Aug 20;23(16) doi: 10.3390/ijms23169421. PMID: 36012688Free PMC Article
Prognostic relevance of ATM protein in uveal melanoma and its association with clinicopathological factors.
Jha J, Singh MK, Singh L, Pushker N, Bajaj MS, Sen S, Kashyap S
Int J Clin Oncol 2019 Dec;24(12):1526-1535. Epub 2019 Aug 3 doi: 10.1007/s10147-019-01519-6. PMID: 31377937
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Luyten GP, Naus NC, Mooy CM, Hagemeijer A, Kan-Mitchell J, Van Drunen E, Vuzevski V, De Jong PT, Luider TM
Int J Cancer 1996 May 3;66(3):380-7. doi: 10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F. PMID: 8621261

Recent systematic reviews

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

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