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EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

MedGen UID:
234224
•Concept ID:
C1333429
•
Neoplastic Process
Synonyms: EBV Related Clonal PTLD; EBV-Related Clonal PTLD; Epstein-Barr Virus-Related Clonal Post-Transplant Lymphoproliferative Disorder

Definition

A clonal lymphoproliferative disorder that develops following an organ transplantation and is caused by Epstein-Barr virus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

Recent clinical studies

Etiology

Epstein-Barr Virus-related post-transplant lymphoproliferative disorders: pathogenetic insights for targeted therapy.
Nourse JP, Jones K, Gandhi MK
Am J Transplant 2011 May;11(5):888-95. doi: 10.1111/j.1600-6143.2011.03499.x. PMID: 21521464
Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
Ohta H, Fukushima N, Ozono K
Int J Hematol 2009 Sep;90(2):127-136. Epub 2009 Aug 12 doi: 10.1007/s12185-009-0399-x. PMID: 19669857

Diagnosis

Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
Ohta H, Fukushima N, Ozono K
Int J Hematol 2009 Sep;90(2):127-136. Epub 2009 Aug 12 doi: 10.1007/s12185-009-0399-x. PMID: 19669857
Epstein-Barr virus positive large B-cell lymphoma arising in a patient previously treated with Cladribine for hairy cell leukemia.
Bhargava R, Barbashina V, Filippa DA, Teruya-Feldstein J
Leuk Lymphoma 2004 May;45(5):1043-8. doi: 10.1080/10428190310001625890. PMID: 15291365

Therapy

Epstein-Barr Virus-related post-transplant lymphoproliferative disorders: pathogenetic insights for targeted therapy.
Nourse JP, Jones K, Gandhi MK
Am J Transplant 2011 May;11(5):888-95. doi: 10.1111/j.1600-6143.2011.03499.x. PMID: 21521464
Epstein-Barr virus positive large B-cell lymphoma arising in a patient previously treated with Cladribine for hairy cell leukemia.
Bhargava R, Barbashina V, Filippa DA, Teruya-Feldstein J
Leuk Lymphoma 2004 May;45(5):1043-8. doi: 10.1080/10428190310001625890. PMID: 15291365
Development of a biologically distinct EBV-related lymphoproliferative disorder following autologous bone marrow transplantation for an EBV-negative post-renal allograft Burkitt's lymphoma.
Lohrisch CA, Nevill TJ, Barnett MJ, Hogge DE, Connors JM, Keown PA, Gascoyne RD
Leuk Lymphoma 2000 Sep;39(1-2):195-201. doi: 10.3109/10428190009053554. PMID: 10975399
Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with clonal lymphoproliferative disorders after orthotopic liver transplantation: a report of three cases.
Zompi S, Tulliez M, Conti F, Leblond V, Gaulard P, Blanche P, Durand F, Ghandi D, Dreyfus F, Louvel A, Calmus Y, Bouscary D
J Hepatol 2000 Mar;32(3):521-7. doi: 10.1016/s0168-8278(00)80406-7. PMID: 10735625

Prognosis

Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
Ohta H, Fukushima N, Ozono K
Int J Hematol 2009 Sep;90(2):127-136. Epub 2009 Aug 12 doi: 10.1007/s12185-009-0399-x. PMID: 19669857
Epstein-Barr virus positive large B-cell lymphoma arising in a patient previously treated with Cladribine for hairy cell leukemia.
Bhargava R, Barbashina V, Filippa DA, Teruya-Feldstein J
Leuk Lymphoma 2004 May;45(5):1043-8. doi: 10.1080/10428190310001625890. PMID: 15291365

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