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Extragastrointestinal Gastrointestinal Stromal Tumor

MedGen UID:
234242
•Concept ID:
C1333500
•
Neoplastic Process
Synonym: Extragastrointestinal Stromal Tumor

Definition

A rare gastrointestinal stromal tumor that presents as a solitary mass outside the gastrointestinal tract. [from NCI]

Professional guidelines

PubMed

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study - a tertiary care center experience.
Patnayak R, Jena A, Parthasarathy S, Prasad PD, Reddy MK, Chowhan AK, Rukamangadha N, Phaneendra BV
Indian J Cancer 2013 Jan-Mar;50(1):41-5. doi: 10.4103/0019-509X.112298. PMID: 23713043
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425

Recent clinical studies

Etiology

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Recurrent Extra-gastrointestinal Stromal Tumor of the Vagina: A Case Report and Review of the Literature.
Shi J, Fu R, Hec W, Zhao A
Niger J Clin Pract 2020 Dec;23(12):1776-1779. doi: 10.4103/njcp.njcp_139_19. PMID: 33355835
Primary prostatic extragastrointestinal stromal tumor: a case report and literature review.
You YH, Zhang Y
J Int Med Res 2018 Oct;46(10):4343-4349. Epub 2018 Aug 28 doi: 10.1177/0300060518791677. PMID: 30152251Free PMC Article
Extragastrointestinal Stromal Tumor (EGIST): A 16-Year Experience of 13 Cases Diagnosed at a Single Center.
Hatipoğlu E
Med Sci Monit 2018 May 19;24:3301-3306. doi: 10.12659/MSM.907654. PMID: 29777611Free PMC Article
Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329

Therapy

Extra-gastrointestinal stromal tumor arising in the lesser omentum with a platelet-derived growth factor receptor alpha (PDGFRA) mutation: a case report and literature review.
Kanamori K, Yamagata Y, Honma Y, Date K, Wada T, Hayashi T, Otsuki S, Sekine S, Yoshikawa T, Katai H, Nishida T
World J Surg Oncol 2020 Jul 23;18(1):183. doi: 10.1186/s12957-020-01961-1. PMID: 32703220Free PMC Article
Extraintestinal gastrointestinal stromal tumor of undetermined origin: Is the mass resection a wrong approach? A case report and review of the literature.
Yüksel ÖH, Akan S, Yildirim Ç, Ürkmez A, Verit A
Arch Ital Urol Androl 2015 Jul 7;87(2):177-8. doi: 10.4081/aiua.2015.2.177. PMID: 26150044
An unexpected but interesting response to a novel therapy for malignant extragastrointestinal stromal tumor of the mesoileum: a case report and review of the literature.
Li H, Li J, Li X, Kang Y, Wei Q
World J Surg Oncol 2013 Aug 5;11(1):174. doi: 10.1186/1477-7819-11-174. PMID: 23915013Free PMC Article
Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature.
Vij M, Agrawal V, Pandey R
JOP 2011 Mar 9;12(2):200-4. PMID: 21386653
Liver transplantation for metastasized extragastrointestinal stromal tumor: a case report and an overview of literature.
Frilling A, Malago M, Testa G, Schleyer E, Grabellus F, Kronenberger R, Li J, Broelsch CE
Transplant Proc 2010 Nov;42(9):3843-8. doi: 10.1016/j.transproceed.2010.06.016. PMID: 21094867

Prognosis

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Laparoscopic Resection of An Extragastrointestinal Stromal Tumor in the Presacral Area.
Sezgin B, Camuzcuoğlu A, Camuzcuoğlu H
J Minim Invasive Gynecol 2019 Jul-Aug;26(5):812-813. Epub 2018 Nov 2 doi: 10.1016/j.jmig.2018.10.023. PMID: 30395935
The primary extra-gastrointestinal stromal tumor of pleura: a case report and a literature review.
Yi JH, Sim J, Park BB, Lee YY, Jung WS, Jang HJ, Ha TK, Paik SS
Jpn J Clin Oncol 2013 Dec;43(12):1269-72. Epub 2013 Oct 29 doi: 10.1093/jjco/hyt158. PMID: 24168806
Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature.
Vij M, Agrawal V, Pandey R
JOP 2011 Mar 9;12(2):200-4. PMID: 21386653
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820

Clinical prediction guides

Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Extraintestinal gastrointestinal stromal tumor of undetermined origin: Is the mass resection a wrong approach? A case report and review of the literature.
Yüksel ÖH, Akan S, Yildirim Ç, Ürkmez A, Verit A
Arch Ital Urol Androl 2015 Jul 7;87(2):177-8. doi: 10.4081/aiua.2015.2.177. PMID: 26150044
Tumor sites and microscopic indicators are independent prognosis predictors of gastrointestinal stromal tumors.
Qi Y, Zhao W, Wang Z, Li T, Meng X
Tohoku J Exp Med 2014 May;233(1):65-72. doi: 10.1620/tjem.233.65. PMID: 24827382
Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases.
Orosz Z, Tornóczky T, Sápi Z
Pathol Oncol Res 2005;11(1):11-21. Epub 2005 Mar 31 doi: 10.1007/BF03032400. PMID: 15800677
c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue).
Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, Saito T, Oshiro Y, Ohta M, Yao T, Tsuneyoshi M
Am J Surg Pathol 2004 Apr;28(4):479-88. doi: 10.1097/00000478-200404000-00007. PMID: 15087667

Recent systematic reviews

Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion: A case report and systematic literature review.
Xu L, Zhang M, Xu M
Medicine (Baltimore) 2019 May;98(20):e15482. doi: 10.1097/MD.0000000000015482. PMID: 31096446Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329

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