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Extragastrointestinal Gastrointestinal Stromal Tumor

MedGen UID:
234242
•Concept ID:
C1333500
•
Neoplastic Process
Synonym: Extragastrointestinal Stromal Tumor

Definition

A rare gastrointestinal stromal tumor that presents as a solitary mass outside the gastrointestinal tract. [from NCI]

Professional guidelines

PubMed

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study - a tertiary care center experience.
Patnayak R, Jena A, Parthasarathy S, Prasad PD, Reddy MK, Chowhan AK, Rukamangadha N, Phaneendra BV
Indian J Cancer 2013 Jan-Mar;50(1):41-5. doi: 10.4103/0019-509X.112298. PMID: 23713043
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425

Recent clinical studies

Etiology

Survival analysis of extragastrointestinal stromal tumors based on the SEER database: a population-based study.
Liu L, Feng Y, Ye Y, Wang Z, Xu X
Surg Endosc 2023 Nov;37(11):8498-8510. Epub 2023 Sep 28 doi: 10.1007/s00464-023-10433-y. PMID: 37770606
Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Survival analysis of extragastrointestinal stromal tumors based on the SEER database: a population-based study.
Liu L, Feng Y, Ye Y, Wang Z, Xu X
Surg Endosc 2023 Nov;37(11):8498-8510. Epub 2023 Sep 28 doi: 10.1007/s00464-023-10433-y. PMID: 37770606
Primary prostatic extragastrointestinal stromal tumor: a case report and literature review.
You YH, Zhang Y
J Int Med Res 2018 Oct;46(10):4343-4349. Epub 2018 Aug 28 doi: 10.1177/0300060518791677. PMID: 30152251Free PMC Article
Extragastrointestinal Stromal Tumor (EGIST): A 16-Year Experience of 13 Cases Diagnosed at a Single Center.
Hatipoğlu E
Med Sci Monit 2018 May 19;24:3301-3306. doi: 10.12659/MSM.907654. PMID: 29777611Free PMC Article
Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329

Therapy

Diffuse primary extra-gastrointestinal stromal tumor of the peritoneum: A rare case report.
Lu LJ, Xu XP, Dong F, Min J
Medicine (Baltimore) 2020 Oct 2;99(40):e22493. doi: 10.1097/MD.0000000000022493. PMID: 33019445Free PMC Article
Extra-gastrointestinal stromal tumor arising in the lesser omentum with a platelet-derived growth factor receptor alpha (PDGFRA) mutation: a case report and literature review.
Kanamori K, Yamagata Y, Honma Y, Date K, Wada T, Hayashi T, Otsuki S, Sekine S, Yoshikawa T, Katai H, Nishida T
World J Surg Oncol 2020 Jul 23;18(1):183. doi: 10.1186/s12957-020-01961-1. PMID: 32703220Free PMC Article
Primary Extragastrointestinal Stromal Tumours in the Hepatobiliary Tree and Telocytes.
Padhi S, Nayak HK
Adv Exp Med Biol 2016;913:207-228. doi: 10.1007/978-981-10-1061-3_14. PMID: 27796890
An unexpected but interesting response to a novel therapy for malignant extragastrointestinal stromal tumor of the mesoileum: a case report and review of the literature.
Li H, Li J, Li X, Kang Y, Wei Q
World J Surg Oncol 2013 Aug 5;11(1):174. doi: 10.1186/1477-7819-11-174. PMID: 23915013Free PMC Article
Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature.
Vij M, Agrawal V, Pandey R
JOP 2011 Mar 9;12(2):200-4. PMID: 21386653

Prognosis

Survival analysis of extragastrointestinal stromal tumors based on the SEER database: a population-based study.
Liu L, Feng Y, Ye Y, Wang Z, Xu X
Surg Endosc 2023 Nov;37(11):8498-8510. Epub 2023 Sep 28 doi: 10.1007/s00464-023-10433-y. PMID: 37770606
Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Laparoscopic Resection of An Extragastrointestinal Stromal Tumor in the Presacral Area.
Sezgin B, Camuzcuoğlu A, Camuzcuoğlu H
J Minim Invasive Gynecol 2019 Jul-Aug;26(5):812-813. Epub 2018 Nov 2 doi: 10.1016/j.jmig.2018.10.023. PMID: 30395935
Tumor sites and microscopic indicators are independent prognosis predictors of gastrointestinal stromal tumors.
Qi Y, Zhao W, Wang Z, Li T, Meng X
Tohoku J Exp Med 2014 May;233(1):65-72. doi: 10.1620/tjem.233.65. PMID: 24827382
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820

Clinical prediction guides

Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Retrospective analysis of extra-gastrointestinal stromal tumors.
Yi JH, Park BB, Kang JH, Hwang IG, Shin DB, Sym SJ, Ahn HK, Lee SI, Lim DH, Park KW, Won YW, Lim SH, Park SH
World J Gastroenterol 2015 Feb 14;21(6):1845-50. doi: 10.3748/wjg.v21.i6.1845. PMID: 25684950Free PMC Article
Tumor sites and microscopic indicators are independent prognosis predictors of gastrointestinal stromal tumors.
Qi Y, Zhao W, Wang Z, Li T, Meng X
Tohoku J Exp Med 2014 May;233(1):65-72. doi: 10.1620/tjem.233.65. PMID: 24827382
Androgen receptor expression in gastrointestinal stromal tumor.
Lopes LF, Bacchi CE
Appl Immunohistochem Mol Morphol 2009 Mar;17(2):146-50. doi: 10.1097/PAI.0b013e31818fcfde. PMID: 19077908
c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue).
Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, Saito T, Oshiro Y, Ohta M, Yao T, Tsuneyoshi M
Am J Surg Pathol 2004 Apr;28(4):479-88. doi: 10.1097/00000478-200404000-00007. PMID: 15087667

Recent systematic reviews

Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion: A case report and systematic literature review.
Xu L, Zhang M, Xu M
Medicine (Baltimore) 2019 May;98(20):e15482. doi: 10.1097/MD.0000000000015482. PMID: 31096446Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329

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