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Fibrous synovial sarcoma

MedGen UID:
234267
•Concept ID:
C1333616
•
Neoplastic Process
Synonyms: fibrous sarcoma of synovium; fibrous sarcoma of the synovium; Fibrous Synovial Sarcoma; fibrous synovial sarcoma
 
Monarch Initiative: MONDO:0003465

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrous synovial sarcoma

Professional guidelines

PubMed

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):178-86. Epub 2015 Mar 26 doi: 10.1177/0394632015575977. PMID: 25816393

Recent clinical studies

Etiology

Reduced expression of SMARCB1/INI1 protein in synovial sarcoma.
Kohashi K, Oda Y, Yamamoto H, Tamiya S, Matono H, Iwamoto Y, Taguchi T, Tsuneyoshi M
Mod Pathol 2010 Jul;23(7):981-90. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.71. PMID: 20305614
Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: a morphologic and immunocytochemical analysis of bcl-2 protein expression.
Viguer JM, Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, Gamallo C
Cancer 1998 Feb 25;84(1):50-6. PMID: 9500652

Diagnosis

Whorling cellular perineurioma: A previously undescribed variant closely mimicking monophasic fibrous synovial sarcoma.
Michal M, Kazakov DV, Agaimy A, Hosova M, Michalova K, Grossmann P, Steiner P, Skenderi F, Vranic S, Michal M
Ann Diagn Pathol 2017 Apr;27:74-78. Epub 2017 Feb 2 doi: 10.1016/j.anndiagpath.2017.02.001. PMID: 28325366
Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma.
Bergman S, Brownlee NA, Geisinger KR, Ward WG, Pettenati MJ, Koty P, Ellis E, Beaty MW, Kilpatrick SE
Diagn Cytopathol 2006 Nov;34(11):761-7. doi: 10.1002/dc.20566. PMID: 17121200
Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues.
Laskin WB, Miettinen M
Arch Pathol Lab Med 2002 Apr;126(4):425-31. doi: 10.5858/2002-126-0425-ETANTC. PMID: 11900566
Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: a morphologic and immunocytochemical analysis of bcl-2 protein expression.
Viguer JM, Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, Gamallo C
Cancer 1998 Feb 25;84(1):50-6. PMID: 9500652
Primary pulmonary sarcoma with morphologic features of monophasic synovial sarcoma and chromosome translocation t(X; 18).
Kaplan MA, Goodman MD, Satish J, Bhagavan BS, Travis WD
Am J Clin Pathol 1996 Feb;105(2):195-9. doi: 10.1093/ajcp/105.2.195. PMID: 8607444

Prognosis

Expression of the LIM homeobox domain transcription factor ISL1 (Islet-1) is frequent in rhabdomyosarcoma but very limited in other soft tissue sarcoma types.
Erlenbach-Wünsch K, Haller F, Taubert H, Würl P, Hartmann A, Agaimy A
Pathology 2014 Jun;46(4):289-95. doi: 10.1097/PAT.0000000000000091. PMID: 24751901
Reduced expression of SMARCB1/INI1 protein in synovial sarcoma.
Kohashi K, Oda Y, Yamamoto H, Tamiya S, Matono H, Iwamoto Y, Taguchi T, Tsuneyoshi M
Mod Pathol 2010 Jul;23(7):981-90. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.71. PMID: 20305614
Pathologic quiz case 1. Monophasic fibrous synovial sarcoma (SS).
Burton DM, Patow CA
Arch Otolaryngol Head Neck Surg 1990 Nov;116(11):1342-5. PMID: 2173621

Clinical prediction guides

Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues.
Laskin WB, Miettinen M
Arch Pathol Lab Med 2002 Apr;126(4):425-31. doi: 10.5858/2002-126-0425-ETANTC. PMID: 11900566
Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: a morphologic and immunocytochemical analysis of bcl-2 protein expression.
Viguer JM, Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, Gamallo C
Cancer 1998 Feb 25;84(1):50-6. PMID: 9500652

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