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Grade 3 Invasive Breast Carcinoma

MedGen UID:
234317
Concept ID:
C1333843
Neoplastic Process
Synonyms: Grade 3 Infiltrating Breast Carcinoma; High Combined Histologic Grade Infiltrating Breast Carcinoma; Poorly Differentiated Infiltrating Breast Carcinoma; Poorly Differentiated Invasive Breast Carcinoma; Unfavorable Infiltrating Breast Carcinoma

Definition

A poorly differentiated invasive breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Invasive Breast Carcinoma

Professional guidelines

PubMed

Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Conte P, Ascierto PA, Patelli G, Danesi R, Vanzulli A, Sandomenico F, Tarsia P, Cattelan A, Comes A, De Laurentiis M, Falcone A, Regge D, Richeldi L, Siena S
ESMO Open 2022 Apr;7(2):100404. Epub 2022 Feb 24 doi: 10.1016/j.esmoop.2022.100404. PMID: 35219244Free PMC Article
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Etiology

Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Akkus G, Koyuturk LC, Yilmaz M, Hancer S, Ozercan IH, Kuloglu T
Tissue Cell 2022 Aug;77:101855. Epub 2022 Jun 17 doi: 10.1016/j.tice.2022.101855. PMID: 35749857
Astuti A, Miskad UA, Arsyadi G, Zainuddin AA, Wahid S, Nelwan BJ
Asian Pac J Cancer Prev 2022 May 1;23(5):1813-1816. doi: 10.31557/APJCP.2022.23.5.1813. PMID: 35633568Free PMC Article
Rakha EA, Varga Z, Elsheik S, Ellis IO
Histopathology 2015 Apr;66(5):740-6. Epub 2014 Dec 22 doi: 10.1111/his.12591. PMID: 25382726

Diagnosis

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Ma T, Semsarian CR, Barratt A, Parker L, Pathmanathan N, Nickel B, Bell KJL
Breast Cancer Res Treat 2023 Jun;199(3):415-433. Epub 2023 Apr 19 doi: 10.1007/s10549-023-06934-y. PMID: 37074481Free PMC Article
Henna N, Rehman A, Niazi FB, Sami W, Aslam U
Asian Pac J Cancer Prev 2022 Mar 1;23(3):971-975. doi: 10.31557/APJCP.2022.23.3.971. PMID: 35345370Free PMC Article
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418

Therapy

Amgad M, Hodge JM, Elsebaie MAT, Bodelon C, Puvanesarajah S, Gutman DA, Siziopikou KP, Goldstein JA, Gaudet MM, Teras LR, Cooper LAD
Nat Med 2024 Jan;30(1):85-97. Epub 2023 Nov 27 doi: 10.1038/s41591-023-02643-7. PMID: 38012314
Toi M, Imoto S, Ishida T, Ito Y, Iwata H, Masuda N, Mukai H, Saji S, Shimizu A, Ikeda T, Haga H, Saeki T, Aogi K, Sugie T, Ueno T, Kinoshita T, Kai Y, Kitada M, Sato Y, Jimbo K, Sato N, Ishiguro H, Takada M, Ohashi Y, Ohno S
Lancet Oncol 2021 Jan;22(1):74-84. doi: 10.1016/S1470-2045(20)30534-9. PMID: 33387497
Murray Brunt A, Haviland JS, Wheatley DA, Sydenham MA, Alhasso A, Bloomfield DJ, Chan C, Churn M, Cleator S, Coles CE, Goodman A, Harnett A, Hopwood P, Kirby AM, Kirwan CC, Morris C, Nabi Z, Sawyer E, Somaiah N, Stones L, Syndikus I, Bliss JM, Yarnold JR; FAST-Forward Trial Management Group
Lancet 2020 May 23;395(10237):1613-1626. Epub 2020 Apr 28 doi: 10.1016/S0140-6736(20)30932-6. PMID: 32580883Free PMC Article
Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA, Kuske RR, Ganz PA, Parda DS, Scheier MF, Winter KA, Paik S, Kuerer HM, Vallow LA, Pierce LJ, Mamounas EP, McCormick B, Costantino JP, Bear HD, Germain I, Gustafson G, Grossheim L, Petersen IA, Hudes RS, Curran WJ Jr, Bryant JL, Wolmark N
Lancet 2019 Dec 14;394(10215):2155-2164. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)32514-0. PMID: 31813636Free PMC Article
Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM; PRIME II investigators
Lancet Oncol 2015 Mar;16(3):266-73. Epub 2015 Jan 28 doi: 10.1016/S1470-2045(14)71221-5. PMID: 25637340

Prognosis

Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Astuti A, Miskad UA, Arsyadi G, Zainuddin AA, Wahid S, Nelwan BJ
Asian Pac J Cancer Prev 2022 May 1;23(5):1813-1816. doi: 10.31557/APJCP.2022.23.5.1813. PMID: 35633568Free PMC Article
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Zhang YW, Ma J, Shi CT, Han W, Gao XJ, Zhou MH, Ding HZ, Wang HN
Curr Probl Cancer 2020 Oct;44(5):100559. Epub 2020 Feb 21 doi: 10.1016/j.currproblcancer.2020.100559. PMID: 32115254
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418

Clinical prediction guides

McMurtry V, Cleary AS, Ruano AL, Lomo L, Gulbahce HE
Am J Clin Oncol 2023 Dec 1;46(12):559-566. Epub 2023 Sep 14 doi: 10.1097/COC.0000000000001041. PMID: 37705411
Schandiz H, Park D, Kaiser YL, Lyngra M, Talleraas IS, Geisler J, Sauer T
Breast Cancer Res Treat 2023 Sep;201(2):329-338. Epub 2023 Jul 15 doi: 10.1007/s10549-023-07016-9. PMID: 37453021Free PMC Article
Henna N, Rehman A, Niazi FB, Sami W, Aslam U
Asian Pac J Cancer Prev 2022 Mar 1;23(3):971-975. doi: 10.31557/APJCP.2022.23.3.971. PMID: 35345370Free PMC Article
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

Recent systematic reviews

Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Zhang M, Song J, Guo S, Jin F, Zheng A
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jul 11 doi: 10.1530/ERC-22-0365. PMID: 37283514
Afzal F, Aiman W, Zahoor H, Bajwa AR, Kazmi SH, Anwar A, Anwar MY, Rashid S, Zubair H, Kashif T, Ashar Ali M
Breast Dis 2023;42(1):121-136. doi: 10.3233/BD-220052. PMID: 37125539
Qi R, Lin J, Chen S, Jiang J, Zhang X, Yao B, Zheng H, Jin Z, Yuan Y, Hou W, Hua B, Guo Q
BMJ Support Palliat Care 2022 Dec;12(e6):e893-e905. Epub 2020 Sep 17 doi: 10.1136/bmjspcare-2020-002204. PMID: 32943470
Lodi M, Scheer L, Reix N, Heitz D, Carin AJ, Thiébaut N, Neuberger K, Tomasetto C, Mathelin C
Breast Cancer Res Treat 2017 Dec;166(3):657-668. Epub 2017 Aug 12 doi: 10.1007/s10549-017-4448-5. PMID: 28803352

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