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Grade 3 Colon Adenocarcinoma

MedGen UID:
234319
Concept ID:
C1333855
Neoplastic Process
Synonyms: Grade III Colon Adenocarcinoma; Poorly Differentiated Colon Adenocarcinoma

Definition

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Colon Adenocarcinoma

Professional guidelines

PubMed

Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A, Saunders BP, Thomas-Gibson S, Tolan DJM, Whyte S, Bonnington S, Scope A, Wong R, Hibbert B, Marsh J, Moores B, Cross A, Sharp L
Gut 2020 Feb;69(2):201-223. Epub 2019 Nov 27 doi: 10.1136/gutjnl-2019-319858. PMID: 31776230Free PMC Article

Recent clinical studies

Etiology

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, Bonetti A, Clingan P, Bridgewater J, Rivera F, de Gramont A
J Clin Oncol 2009 Jul 1;27(19):3109-16. Epub 2009 May 18 doi: 10.1200/JCO.2008.20.6771. PMID: 19451431
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436

Diagnosis

Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Sugarbaker PH
Ann Surg Oncol 2017 Mar;24(3):729-732. Epub 2016 Oct 21 doi: 10.1245/s10434-016-5632-2. PMID: 27770344
Health Quality Ontario
Ont Health Technol Assess Ser 2015;15(14):1-39. Epub 2015 Jul 1 PMID: 26366239Free PMC Article

Therapy

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436

Prognosis

Ma Z, Yang S, Yang Y, Luo J, Zhou Y, Yang H
Front Endocrinol (Lausanne) 2023;14:1073360. Epub 2023 Jul 31 doi: 10.3389/fendo.2023.1073360. PMID: 37583430Free PMC Article
Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
He Y, Chen Y, Dai X, Huang S
Comput Math Methods Med 2022;2022:4957996. Epub 2022 Jul 16 doi: 10.1155/2022/4957996. PMID: 35880088Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article

Clinical prediction guides

Chalabi M, Verschoor YL, Tan PB, Balduzzi S, Van Lent AU, Grootscholten C, Dokter S, Büller NV, Grotenhuis BA, Kuhlmann K, Burger JW, Huibregtse IL, Aukema TS, Hendriks ER, Oosterling SJ, Snaebjornsson P, Voest EE, Wessels LF, Beets-Tan RG, Van Leerdam ME, Schumacher TN, van den Berg JG, Beets GL, Haanen JB
N Engl J Med 2024 Jun 6;390(21):1949-1958. doi: 10.1056/NEJMoa2400634. PMID: 38838311
Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Teijeira A, Migueliz I, Garasa S, Karanikas V, Luri C, Cirella A, Olivera I, Cañamero M, Alvarez M, Ochoa MC, Rouzaut A, Rodriguez-Ruiz ME, Sanmamed MF, Klein C, Umaña P, Ponz M, Bacac M, Melero I
Theranostics 2022;12(3):1373-1387. Epub 2022 Jan 1 doi: 10.7150/thno.63359. PMID: 35154495Free PMC Article
Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article

Recent systematic reviews

Xu J, Mohan HM, Fleming C, Larach JT, Apte SS, Cohen LCL, Miskovic D, Jiang W, Heriot AG, Warrier SK
Tech Coloproctol 2023 Nov;27(11):995-1005. Epub 2023 Jul 7 doi: 10.1007/s10151-023-02838-7. PMID: 37414915
Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Meester RGS, van Herk MMAGC, Lansdorp-Vogelaar I, Ladabaum U
Gastroenterology 2020 Jul;159(1):105-118.e25. Epub 2020 Mar 18 doi: 10.1053/j.gastro.2020.03.025. PMID: 32199884Free PMC Article
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986

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