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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma

MedGen UID:
234323
Concept ID:
C1333878
Neoplastic Process
Synonyms: B-cell lymphoma unclassifiable with features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma; B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma; B-cell lymphoma, unclassifiable, with features Intermediate between diffuse large B-cell lymphoma and Classic Hodgkin lymphoma; B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma; B-cell lymphoma, unclassifiable, with features Intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma; Gray Zone Lymphoma; Gray zone lymphoma; Grey zone lymphoma; Hodgkin-Like Anaplastic Large Cell Lymphoma; Hodgkin-like anaplastic large cell lymphoma; Large B-Cell Lymphoma with Hodgkin Features; large B-cell lymphoma with Hodgkin features
SNOMED CT: B-cell lymphoma unclassifiable with features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma (722954005)
 
Monarch Initiative: MONDO:0003658

Definition

A group of lymphomas displaying molecular, morphologic, immunophenotypic, and clinical overlap between classic Hodgkin lymphoma and diffuse large B-cell lymphoma. This term particularly applies to mediastinal lymphomas with overlapping features of mediastinal (thymic) large B-cell lymphoma and classic Hodgkin lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma

Professional guidelines

Recent clinical studies

Etiology

Kim HJ, Kim HK, Park G, Min SK, Cha HJ, Lee H, Choi SJ, Na HY, Choe JY, Kim JE
Diagn Pathol 2019 Dec 12;14(1):133. doi: 10.1186/s13000-019-0918-x. PMID: 31831043Free PMC Article
Laušević M, Markovic-Lipkovski J, Terzić T, Jovanović N, Milinković M, Naumović R
Srp Arh Celok Lek 2016 May-Jun;144(5-6):325-8. PMID: 29648755
O'Malley DP, Fedoriw Y, Weiss LM
Appl Immunohistochem Mol Morphol 2016 Sep;24(8):535-40. doi: 10.1097/PAI.0000000000000236. PMID: 26447896
Mohamedbhai SG, Sibson K, Marafioti T, Kayani I, Lowry L, Goldstone AH, Linch DC, Ardeshna KM
Br J Haematol 2011 Jan;152(2):175-81. Epub 2010 Nov 24 doi: 10.1111/j.1365-2141.2010.08447.x. PMID: 21092025
Carbone A, Gloghini A, Aiello A, Testi A, Cabras A
Hum Pathol 2010 May;41(5):621-31. doi: 10.1016/j.humpath.2009.10.027. PMID: 20398809

Diagnosis

Gibson SE, Dojcinov S, Dotlic S, Hartmann S, Hsi ED, Klimkowska M, Melle F, Pileri SA, Ramsower CA, Rech K, Rimsza LM, Rodriguez-Pinilla SM, Tousseyn TA, de Jong D, Sabattini E
Virchows Arch 2023 Dec;483(6):733-749. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03550-5. PMID: 37530791Free PMC Article
Tousseyn TA, King RL, Fend F, Feldman AL, Brousset P, Jaffe ES
Virchows Arch 2023 Jan;482(1):207-226. Epub 2022 Oct 24 doi: 10.1007/s00428-022-03427-z. PMID: 36274093
Hernández Martínez M, Lizán Tudela C, Saus Carreres A
BMJ Case Rep 2021 Feb 24;14(2) doi: 10.1136/bcr-2020-239462. PMID: 33627347Free PMC Article
O'Malley DP, Fedoriw Y, Weiss LM
Appl Immunohistochem Mol Morphol 2016 Sep;24(8):535-40. doi: 10.1097/PAI.0000000000000236. PMID: 26447896
Carbone A, Gloghini A, Aiello A, Testi A, Cabras A
Hum Pathol 2010 May;41(5):621-31. doi: 10.1016/j.humpath.2009.10.027. PMID: 20398809

Therapy

Hernández Martínez M, Lizán Tudela C, Saus Carreres A
BMJ Case Rep 2021 Feb 24;14(2) doi: 10.1136/bcr-2020-239462. PMID: 33627347Free PMC Article
Kritharis A, Pilichowska M, Evens AM
Br J Haematol 2016 Aug;174(3):345-50. Epub 2016 Jun 15 doi: 10.1111/bjh.14174. PMID: 27301470
Rentas Torres Y, Rodríguez-López JL, Valentin M, Silva H
Bol Asoc Med P R 2015 Jul-Sep;107(3):98-101. PMID: 26742206
Dunleavy K, Grant C, Eberle FC, Pittaluga S, Jaffe ES, Wilson WH
Curr Hematol Malig Rep 2012 Sep;7(3):241-7. doi: 10.1007/s11899-012-0130-5. PMID: 22833351Free PMC Article
Gualco G, Natkunam Y, Bacchi CE
Mod Pathol 2012 May;25(5):661-74. Epub 2012 Jan 6 doi: 10.1038/modpathol.2011.200. PMID: 22222636

Prognosis

Van Slambrouck C, Huh J, Suh C, Song JY, Menon MP, Sohani AR, Duffield AS, Goldberg RC, Dama P, Kiyotani K, Godfrey J, Fitzpatrick C, Kline J, Smith SM, Jaffe ES, Hartmann S, Venkataraman G
Mod Pathol 2020 May;33(5):834-845. Epub 2019 Dec 10 doi: 10.1038/s41379-019-0428-0. PMID: 31822802Free PMC Article
Parker K, Venkataraman G
Surg Pathol Clin 2019 Sep;12(3):709-718. Epub 2019 May 23 doi: 10.1016/j.path.2019.03.014. PMID: 31352983
Misyurina AE, Kravchenko SK, Mangasarova YK, Magomedova AU, Kovrigina AM, Shimanovskaya LT, Fastova EA, Misyurin VA, Model SV, Chebotarev DI, Kostina IE, Savchenko VG
Ter Arkh 2019 May 16;91(4):107-113. doi: 10.26442/00403660.2019.04.000071. PMID: 31094484
Moore EM, Swerdlow SH, Gibson SE
Hum Pathol 2017 Oct;68:47-53. Epub 2017 Aug 26 doi: 10.1016/j.humpath.2017.08.015. PMID: 28851661
Kritharis A, Pilichowska M, Evens AM
Br J Haematol 2016 Aug;174(3):345-50. Epub 2016 Jun 15 doi: 10.1111/bjh.14174. PMID: 27301470

Clinical prediction guides

Van Slambrouck C, Huh J, Suh C, Song JY, Menon MP, Sohani AR, Duffield AS, Goldberg RC, Dama P, Kiyotani K, Godfrey J, Fitzpatrick C, Kline J, Smith SM, Jaffe ES, Hartmann S, Venkataraman G
Mod Pathol 2020 May;33(5):834-845. Epub 2019 Dec 10 doi: 10.1038/s41379-019-0428-0. PMID: 31822802Free PMC Article
Moore EM, Swerdlow SH, Gibson SE
Hum Pathol 2017 Oct;68:47-53. Epub 2017 Aug 26 doi: 10.1016/j.humpath.2017.08.015. PMID: 28851661
O'Malley DP, Fedoriw Y, Weiss LM
Appl Immunohistochem Mol Morphol 2016 Sep;24(8):535-40. doi: 10.1097/PAI.0000000000000236. PMID: 26447896
Hoeller S, Zihler D, Zlobec I, Obermann EC, Pileri SA, Dirnhofer S, Tzankov A
Histopathology 2010 Jan;56(2):217-28. doi: 10.1111/j.1365-2559.2009.03462.x. PMID: 20102401

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