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Hepatitis C Virus-Related Hepatocellular Carcinoma

MedGen UID:
234341
•Concept ID:
C1333978
•
Neoplastic Process
Synonym: Hepatitis C Virus Related Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis C Virus-Related Hepatocellular Carcinoma

Professional guidelines

PubMed

Prior antiviral treatment and mortality among patients with hepatitis C virus-related hepatocellular carcinoma: A national cohort study.
Sinn DH, Kang D, Hong YS, Koh KC, Guallar E, Cho J, Gwak GY
PLoS One 2021;16(8):e0255624. Epub 2021 Aug 3 doi: 10.1371/journal.pone.0255624. PMID: 34343200Free PMC Article
Direct-Acting Antivirals Improve Treatment Outcomes in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: A Nationwide, Multi-center, Retrospective Cohort Study.
Hyun HK, Cho EJ, Park SY, Hong YM, Kim SS, Kim HY, Heo NY, Park JG, Sinn DH, Kang W, Jeong SW, Song MJ, Park H, Lee D, Lee YS, Cho SB, An CS, Rhee HJ, Lee HW, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Lee JH, Yu SJ, Kim YJ, Yoon JH, Tak WY, Kweon YO, Yoon KT, Cho M, Cheong JY, Park SH, Kim SU; Korean TACE Study Group
Dig Dis Sci 2021 Jul;66(7):2427-2438. Epub 2020 Aug 28 doi: 10.1007/s10620-020-06533-7. PMID: 32856240
The influence of direct-acting antivirals in hepatitis C virus related hepatocellular carcinoma after curative treatment.
Kuo YH, Wang JH, Chang KC, Hung CH, Lu SN, Hu TH, Yen YH, Kee KM, Chen CH
Invest New Drugs 2020 Feb;38(1):202-210. Epub 2019 Nov 8 doi: 10.1007/s10637-019-00870-9. PMID: 31701431

Recent clinical studies

Etiology

Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma.
Huang DQ, Hoang JK, Kamal R, Tsai PC, Toyoda H, Yeh ML, Yasuda S, Leong J, Maeda M, Huang CF, Won Jun D, Ishigami M, Tanaka Y, Uojima H, Ogawa E, Abe H, Hsu YC, Tseng CH, Alsudaney M, Yang JD, Yoshimaru Y, Suzuki T, Liu JK, Landis C, Dai CY, Huang JF, Chuang WL, Schwartz M, Dan YY, Esquivel C, Bonham A, Yu ML, Nguyen MH
J Clin Oncol 2024 Mar 1;42(7):790-799. Epub 2024 Jan 4 doi: 10.1200/JCO.23.00757. PMID: 38175991
Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response.
Park JE, Nguyen VH, Tsai PC, Toyoda H, Leong J, Guy JE, Yeh ML, Huang CF, Yasuda S, Abe H, Hsu YC, Tseng CH, Liu J, Chen YL, Lin PY, Jun DW, Yoshimaru Y, Ogawa E, Ishigami M, Enomoto M, Tamori A, Uojima H, Wang XZ, Xu Q, Takahashi H, Eguchi Y, Inoue K, Huang DQ, Zhao WJ, Chuang WL, Dai CY, Huang JF, Barnett S, Maeda M, Cheung R, Landis C, Tanaka Y, Roberts LR, Schwartz ME, Kumada T, Yu ML, Nguyen MH
Aliment Pharmacol Ther 2024 Mar;59(6):742-751. Epub 2024 Jan 3 doi: 10.1111/apt.17863. PMID: 38173278
Prevalence and characteristics of hepatitis C virus-related hepatocellular carcinoma in a Spanish university hospital.
Canillas L, Parcerisa M, Coll S, García-Retortillo M, Macià F, Bessa X, Castells X, Puigvehí M, Posso M
Cancer Epidemiol 2022 Jun;78:102142. Epub 2022 Mar 19 doi: 10.1016/j.canep.2022.102142. PMID: 35316642
Prevention of hepatitis C virus-related hepatocellular carcinoma.
Heathcote EJ
Gastroenterology 2004 Nov;127(5 Suppl 1):S294-302. doi: 10.1053/j.gastro.2004.09.044. PMID: 15508097
Natural history and pathogenesis of hepatitis C virus related hepatocellular carcinoma.
Colombo M
J Hepatol 1999;31 Suppl 1:25-30. doi: 10.1016/s0168-8278(99)80370-5. PMID: 10622556

Diagnosis

Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma.
Huang DQ, Hoang JK, Kamal R, Tsai PC, Toyoda H, Yeh ML, Yasuda S, Leong J, Maeda M, Huang CF, Won Jun D, Ishigami M, Tanaka Y, Uojima H, Ogawa E, Abe H, Hsu YC, Tseng CH, Alsudaney M, Yang JD, Yoshimaru Y, Suzuki T, Liu JK, Landis C, Dai CY, Huang JF, Chuang WL, Schwartz M, Dan YY, Esquivel C, Bonham A, Yu ML, Nguyen MH
J Clin Oncol 2024 Mar 1;42(7):790-799. Epub 2024 Jan 4 doi: 10.1200/JCO.23.00757. PMID: 38175991
Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response.
Park JE, Nguyen VH, Tsai PC, Toyoda H, Leong J, Guy JE, Yeh ML, Huang CF, Yasuda S, Abe H, Hsu YC, Tseng CH, Liu J, Chen YL, Lin PY, Jun DW, Yoshimaru Y, Ogawa E, Ishigami M, Enomoto M, Tamori A, Uojima H, Wang XZ, Xu Q, Takahashi H, Eguchi Y, Inoue K, Huang DQ, Zhao WJ, Chuang WL, Dai CY, Huang JF, Barnett S, Maeda M, Cheung R, Landis C, Tanaka Y, Roberts LR, Schwartz ME, Kumada T, Yu ML, Nguyen MH
Aliment Pharmacol Ther 2024 Mar;59(6):742-751. Epub 2024 Jan 3 doi: 10.1111/apt.17863. PMID: 38173278
Diagnosis and monitoring of hepatocellular carcinoma in Hepatitis C virus patients using attenuated total reflection Fourier transform infrared spectroscopy.
Ali S, Naveed A, Hussain I, Qazi J
Photodiagnosis Photodyn Ther 2023 Sep;43:103677. Epub 2023 Jun 29 doi: 10.1016/j.pdpdt.2023.103677. PMID: 37390855
Prevalence and characteristics of hepatitis C virus-related hepatocellular carcinoma in a Spanish university hospital.
Canillas L, Parcerisa M, Coll S, García-Retortillo M, Macià F, Bessa X, Castells X, Puigvehí M, Posso M
Cancer Epidemiol 2022 Jun;78:102142. Epub 2022 Mar 19 doi: 10.1016/j.canep.2022.102142. PMID: 35316642
Natural history and pathogenesis of hepatitis C virus related hepatocellular carcinoma.
Colombo M
J Hepatol 1999;31 Suppl 1:25-30. doi: 10.1016/s0168-8278(99)80370-5. PMID: 10622556

Therapy

Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma.
Huang DQ, Hoang JK, Kamal R, Tsai PC, Toyoda H, Yeh ML, Yasuda S, Leong J, Maeda M, Huang CF, Won Jun D, Ishigami M, Tanaka Y, Uojima H, Ogawa E, Abe H, Hsu YC, Tseng CH, Alsudaney M, Yang JD, Yoshimaru Y, Suzuki T, Liu JK, Landis C, Dai CY, Huang JF, Chuang WL, Schwartz M, Dan YY, Esquivel C, Bonham A, Yu ML, Nguyen MH
J Clin Oncol 2024 Mar 1;42(7):790-799. Epub 2024 Jan 4 doi: 10.1200/JCO.23.00757. PMID: 38175991
Racial and ethnic disparities in untreated patients with hepatitis C virus-related hepatocellular carcinoma but not in those with sustained virologic response.
Park JE, Nguyen VH, Tsai PC, Toyoda H, Leong J, Guy JE, Yeh ML, Huang CF, Yasuda S, Abe H, Hsu YC, Tseng CH, Liu J, Chen YL, Lin PY, Jun DW, Yoshimaru Y, Ogawa E, Ishigami M, Enomoto M, Tamori A, Uojima H, Wang XZ, Xu Q, Takahashi H, Eguchi Y, Inoue K, Huang DQ, Zhao WJ, Chuang WL, Dai CY, Huang JF, Barnett S, Maeda M, Cheung R, Landis C, Tanaka Y, Roberts LR, Schwartz ME, Kumada T, Yu ML, Nguyen MH
Aliment Pharmacol Ther 2024 Mar;59(6):742-751. Epub 2024 Jan 3 doi: 10.1111/apt.17863. PMID: 38173278
Impact of Interferon on the Prognosis of Hepatitis C Virus-Related Hepatocellular Carcinoma Patients with a Sustained Virological Response -An Additional Comparison Between Preoperative and Postoperative Sustained Virological Response.
Muroya D, Nishimura T, Kanno H, Kojima S, Fukutomi S, Akashi M, Nomura Y, Goto Y, Sato T, Sakai H, Hisaka T, Akagi Y, Okuda K
Kurume Med J 2023 Apr 4;68(1):9-18. Epub 2023 Feb 8 doi: 10.2739/kurumemedj.MS681001. PMID: 36754382
Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma.
Lithy RM, Omar Abdelaziz A, Awad A, Ibrahim Shousha H, Omran D, Mahmoud Nabil M, Hosni Abdelmaksoud A, Mahmoud Elbaz T, Mabrouk M
Arab J Gastroenterol 2022 Nov;23(4):230-234. Epub 2022 Nov 15 doi: 10.1016/j.ajg.2022.10.008. PMID: 36400702
Prevention of hepatitis C virus-related hepatocellular carcinoma.
Heathcote EJ
Gastroenterology 2004 Nov;127(5 Suppl 1):S294-302. doi: 10.1053/j.gastro.2004.09.044. PMID: 15508097

Prognosis

Impact of Interferon on the Prognosis of Hepatitis C Virus-Related Hepatocellular Carcinoma Patients with a Sustained Virological Response -An Additional Comparison Between Preoperative and Postoperative Sustained Virological Response.
Muroya D, Nishimura T, Kanno H, Kojima S, Fukutomi S, Akashi M, Nomura Y, Goto Y, Sato T, Sakai H, Hisaka T, Akagi Y, Okuda K
Kurume Med J 2023 Apr 4;68(1):9-18. Epub 2023 Feb 8 doi: 10.2739/kurumemedj.MS681001. PMID: 36754382
Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma.
Lithy RM, Omar Abdelaziz A, Awad A, Ibrahim Shousha H, Omran D, Mahmoud Nabil M, Hosni Abdelmaksoud A, Mahmoud Elbaz T, Mabrouk M
Arab J Gastroenterol 2022 Nov;23(4):230-234. Epub 2022 Nov 15 doi: 10.1016/j.ajg.2022.10.008. PMID: 36400702
Prevalence and characteristics of hepatitis C virus-related hepatocellular carcinoma in a Spanish university hospital.
Canillas L, Parcerisa M, Coll S, García-Retortillo M, Macià F, Bessa X, Castells X, Puigvehí M, Posso M
Cancer Epidemiol 2022 Jun;78:102142. Epub 2022 Mar 19 doi: 10.1016/j.canep.2022.102142. PMID: 35316642
Increased DNA damage in hepatitis C virus-related hepatocellular carcinoma.
Shawki SM, Meshaal SS, El Dash AS, Zayed NA, Hanna MO
DNA Cell Biol 2014 Dec;33(12):884-90. doi: 10.1089/dna.2014.2417. PMID: 25211328
Natural history and pathogenesis of hepatitis C virus related hepatocellular carcinoma.
Colombo M
J Hepatol 1999;31 Suppl 1:25-30. doi: 10.1016/s0168-8278(99)80370-5. PMID: 10622556

Clinical prediction guides

Diagnosis and monitoring of hepatocellular carcinoma in Hepatitis C virus patients using attenuated total reflection Fourier transform infrared spectroscopy.
Ali S, Naveed A, Hussain I, Qazi J
Photodiagnosis Photodyn Ther 2023 Sep;43:103677. Epub 2023 Jun 29 doi: 10.1016/j.pdpdt.2023.103677. PMID: 37390855
Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma.
Lithy RM, Omar Abdelaziz A, Awad A, Ibrahim Shousha H, Omran D, Mahmoud Nabil M, Hosni Abdelmaksoud A, Mahmoud Elbaz T, Mabrouk M
Arab J Gastroenterol 2022 Nov;23(4):230-234. Epub 2022 Nov 15 doi: 10.1016/j.ajg.2022.10.008. PMID: 36400702
Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis.
Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R
World J Gastroenterol 2017 Oct 7;23(37):6802-6816. doi: 10.3748/wjg.v23.i37.6802. PMID: 29085224Free PMC Article
Comparison between alcohol- and hepatitis C virus-related hepatocellular carcinoma: clinical presentation, treatment and outcome.
Bucci L, Garuti F, Camelli V, Lenzi B, Farinati F, Giannini EG, Ciccarese F, Piscaglia F, Rapaccini GL, Di Marco M, Caturelli E, Zoli M, Borzio F, Sacco R, Maida M, Felder M, Morisco F, Gasbarrini A, Gemini S, Foschi FG, Missale G, Masotto A, Affronti A, Bernardi M, Trevisani F; Italian Liver Cancer (ITA.LI.CA) Group; Italian Liver Cancer ITA LI CA Group
Aliment Pharmacol Ther 2016 Feb;43(3):385-99. Epub 2015 Dec 14 doi: 10.1111/apt.13485. PMID: 26662476
Increased DNA damage in hepatitis C virus-related hepatocellular carcinoma.
Shawki SM, Meshaal SS, El Dash AS, Zayed NA, Hanna MO
DNA Cell Biol 2014 Dec;33(12):884-90. doi: 10.1089/dna.2014.2417. PMID: 25211328

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