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Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

MedGen UID:
234420
•Concept ID:
C1336717
•
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Teratoma with Seminoma of Testis; Mixed Embryonal Carcinoma and Teratoma with Seminoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Teratoma with Seminoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Clues from natural history and results of treatment supporting the monoclonal origin of germ cell tumours.
Oliver RT
Cancer Surv 1990;9(2):333-68. PMID: 1964626

Recent clinical studies

Etiology

Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253
Cryptorchidism and testicular cancer.
Batata MA, Whitmore WF Jr, Chu FC, Hilaris BS, Loh J, Grabstald H, Golbey R
J Urol 1980 Sep;124(3):382-7. doi: 10.1016/s0022-5347(17)55458-0. PMID: 6107388

Diagnosis

Incidence of testicular tumor subtypes according to the updated WHO classification, North Rhine-Westphalia, Germany, 2008-2013.
Stang A, Rusner C, Trabert B, Oosterhuis JW, McGlynn KA, Heidinger O
Andrology 2019 Jul;7(4):402-407. Epub 2018 Dec 21 doi: 10.1111/andr.12565. PMID: 30578617Free PMC Article
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.
Kao CS, Ulbright TM, Young RH, Idrees MT
Am J Surg Pathol 2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171. PMID: 24503753
Testicular tumors--some new and a few perennial problems.
Young RH
Arch Pathol Lab Med 2008 Apr;132(4):548-64. doi: 10.5858/2008-132-548-TTNAAF. PMID: 18384207
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230

Therapy

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
The management of inferior vena cava obstruction complicating metastatic germ cell tumors.
Hassan B, Tung K, Weeks R, Mead GM
Cancer 1999 Feb 15;85(4):912-8. PMID: 10091770
Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar.
Foster BJ, Javadpour N, Ozols RF
Int J Cell Cloning 1983 Apr;1(1):2-14. doi: 10.1002/stem.5530010103. PMID: 6201566
Testicular cancer in cryptorchids.
Batata MA, Chu FC, Hilaris BS, Whitmore WF, Golbey RB
Cancer 1982 Mar 1;49(5):1023-30. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. PMID: 6120755
Testicular tumors of germ cell origin.
Kaplan JH, Kudish HG, Sacks SA
Postgrad Med 1981 Dec;70(6):125-7, 130-1. doi: 10.1080/00325481.1981.11715938. PMID: 6796949

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
Incidence of testicular tumor subtypes according to the updated WHO classification, North Rhine-Westphalia, Germany, 2008-2013.
Stang A, Rusner C, Trabert B, Oosterhuis JW, McGlynn KA, Heidinger O
Andrology 2019 Jul;7(4):402-407. Epub 2018 Dec 21 doi: 10.1111/andr.12565. PMID: 30578617Free PMC Article
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Cryptorchidism and testicular cancer.
Batata MA, Whitmore WF Jr, Chu FC, Hilaris BS, Loh J, Grabstald H, Golbey R
J Urol 1980 Sep;124(3):382-7. doi: 10.1016/s0022-5347(17)55458-0. PMID: 6107388

Clinical prediction guides

Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.
Zhou Y, Rothrock A, Murugan P, Li F, Bu L
Exp Mol Pathol 2022 Jun;126:104761. Epub 2022 Apr 4 doi: 10.1016/j.yexmp.2022.104761. PMID: 35390309
The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism.
Osterballe L, Clasen-Linde E, Cortes D, Engholm G, Hertzum-Larsen R, Reinhardt S, Thorup J
J Pediatr Surg 2017 Apr;52(4):587-592. Epub 2016 Aug 27 doi: 10.1016/j.jpedsurg.2016.08.006. PMID: 27614808
Primary testicular carcinoid.
Hodzic J, Golka K, Schulze H
Med Sci Monit 2004 Aug;10(8):CS46-8. Epub 2004 Jul 23 PMID: 15278003
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Testicular cancer in cryptorchids.
Batata MA, Chu FC, Hilaris BS, Whitmore WF, Golbey RB
Cancer 1982 Mar 1;49(5):1023-30. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. PMID: 6120755

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