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Rectal Undifferentiated Carcinoma

MedGen UID:
234451
Concept ID:
C1336864
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Rectum; Anaplastic Carcinoma of the Rectum; Carcinoma Simplex of the Rectum.; Rectal Anaplastic Carcinoma; Undifferentiated Carcinoma of Rectum; Undifferentiated Carcinoma of the Rectum; Undifferentiated Rectal Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Undifferentiated Carcinoma

Professional guidelines

PubMed

Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Decanini-Terán CO, González-Acosta J, Obregón-Méndez J, Vega-de Jesús M
Cir Cir 2011 Sep-Oct;79(5):481-7. PMID: 22385771
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Silva DJ, Dos Santos J, Vaz AP, Mesquita A
Medicine (Baltimore) 2021 Oct 8;100(40):e27348. doi: 10.1097/MD.0000000000027348. PMID: 34622834Free PMC Article
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR
JAMA Oncol 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. PMID: 29566109Free PMC Article
Chiu MS, Verma V, Bennion NR, Bhirud AR, Li J, Charlton ME, Are C, Lin C
Cancer Med 2016 Dec;5(12):3394-3402. Epub 2016 Oct 26 doi: 10.1002/cam4.927. PMID: 27781400Free PMC Article
Smart PJ, Burbury KL, Lynch AC, Mackay JR, Heriot AG
Colorectal Dis 2013 Sep;15(9):e496-502. doi: 10.1111/codi.12332. PMID: 23910015

Diagnosis

Congedo A, Mallardi D, Danti G, De Muzio F, Granata V, Miele V
Tomography 2023 Sep 4;9(5):1694-1710. doi: 10.3390/tomography9050135. PMID: 37736988Free PMC Article
Yamamoto T, Kotze PG, Spinelli A, Panaccione R
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):917-925. Epub 2018 Jul 24 doi: 10.1080/17474124.2018.1500175. PMID: 29999429
van der Meij W, Rombouts AJ, Rütten H, Bremers AJ, de Wilt JH
Dis Colon Rectum 2016 Feb;59(2):148-56. doi: 10.1097/DCR.0000000000000547. PMID: 26734974
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Boustani J, Huguet F, Vendrely V
Cancer Radiother 2023 Dec;27(8):768-777. Epub 2023 Oct 26 doi: 10.1016/j.canrad.2023.08.001. PMID: 38415359
Allen SK, Schwab KE, Rockall TA
Minerva Chir 2018 Apr;73(2):227-238. Epub 2018 Feb 21 doi: 10.23736/S0026-4733.18.07572-7. PMID: 29471614
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Nussbaum N, Altomare I
Curr Oncol Rep 2015 Mar;17(3):434. doi: 10.1007/s11912-014-0434-9. PMID: 25691086
Busse PM, Ng A, Recht A
Semin Surg Oncol 1998 Sep;15(2):120-5. doi: 10.1002/(sici)1098-2388(199809)15:2<120::aid-ssu9>3.0.co;2-1. PMID: 9730418

Prognosis

Chen T, Zheng B, Yang P, Zhang Z, Su Y, Chen Y, Luo L, Luo D, Lin Y, Xie R, Zeng L
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):e611-e621. Epub 2023 May 19 doi: 10.1016/j.clon.2023.05.008. PMID: 37263883
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
Lancet Oncol 2017 Mar;18(3):336-346. Epub 2017 Feb 10 doi: 10.1016/S1470-2045(17)30086-4. PMID: 28190762
Messick CA, Rodriguez-Bigas MA
Surg Oncol Clin N Am 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. PMID: 27889035
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403

Clinical prediction guides

Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Pai RK, Pai RK
Mod Pathol 2018 Jan;31(1):4-23. Epub 2017 Aug 4 doi: 10.1038/modpathol.2017.87. PMID: 28776577
Gaertner WB, Kwaan MR, Madoff RD, Melton GB
World J Gastroenterol 2015 Jul 7;21(25):7659-71. doi: 10.3748/wjg.v21.i25.7659. PMID: 26167068Free PMC Article
Lehmann FS, Trapani F, Fueglistaler I, Terracciano LM, von Flüe M, Cathomas G, Zettl A, Benkert P, Oertli D, Beglinger C
World J Gastroenterol 2014 May 7;20(17):4994-9. doi: 10.3748/wjg.v20.i17.4994. PMID: 24803811Free PMC Article

Recent systematic reviews

Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608Free PMC Article
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Zhou C, Ren Y, Li J, Li X, He J, Liu P
J Surg Res 2014 Jun 1;189(1):7-16. Epub 2014 Jan 24 doi: 10.1016/j.jss.2014.01.030. PMID: 24630520
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

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