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Rectal Undifferentiated Carcinoma

MedGen UID:: 234451
•Concept ID:: C1336864
•: Neoplastic Process

Synonyms:

Anaplastic Carcinoma of Rectum; Anaplastic Carcinoma of the Rectum; Carcinoma Simplex of the Rectum.; Rectal Anaplastic Carcinoma; Undifferentiated Carcinoma of Rectum; Undifferentiated Carcinoma of the Rectum; Undifferentiated Rectal Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRectal Undifferentiated Carcinoma

Disorder of intestine
- Intestinal neoplasm
  - Intestinal cancer
    - Colorectal cancer
      - Colorectal carcinoma
        Colorectal Undifferentiated Carcinoma
        Rectal Undifferentiated Carcinoma

Professional guidelines

PubMed

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer.

You YN, Hardiman KM, Bafford A, Poylin V, Francone TD, Davis K, Paquette IM, Steele SR, Feingold DL; On Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2020 Sep;63(9):1191-1222. doi: 10.1097/DCR.0000000000001762. PMID: 33216491

Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.

Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190

Guidelines for the management of iron deficiency anaemia.

Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

See all (976)

Recent clinical studies

Etiology

Survival and prognostic factors in patients with rectal squamous cell carcinoma.

Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124

Fistula-associated anal carcinoma in Crohn's disease.

Yamamoto T, Kotze PG, Spinelli A, Panaccione R
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):917-925. Epub 2018 Jul 24 doi: 10.1080/17474124.2018.1500175. PMID: 29999429

Comparison of outcomes between rectal squamous cell carcinoma and adenocarcinoma.

Chiu MS, Verma V, Bennion NR, Bhirud AR, Li J, Charlton ME, Are C, Lin C
Cancer Med 2016 Dec;5(12):3394-3402. Epub 2016 Oct 26 doi: 10.1002/cam4.927. PMID: 27781400 Free PMC Article

Thromboembolism during neoadjuvant therapy for rectal cancer: a systematic review.

Smart PJ, Burbury KL, Lynch AC, Mackay JR, Heriot AG
Colorectal Dis 2013 Sep;15(9):e496-502. doi: 10.1111/codi.12332. PMID: 23910015

Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04.

Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, Ackland SP, Schache D, McClure B, McLachlan SA, McKendrick J, Leong T, Hartopeanu C, Zalcberg J, Mackay J
J Clin Oncol 2012 Nov 1;30(31):3827-33. Epub 2012 Sep 24 doi: 10.1200/JCO.2012.42.9597. PMID: 23008301

See all (7997)

Diagnosis

Fistula-associated anal carcinoma in Crohn's disease.

Yamamoto T, Kotze PG, Spinelli A, Panaccione R
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):917-925. Epub 2018 Jul 24 doi: 10.1080/17474124.2018.1500175. PMID: 29999429

Treatment of Locally Recurrent Rectal Carcinoma in Previously (Chemo)Irradiated Patients: A Review.

van der Meij W, Rombouts AJ, Rütten H, Bremers AJ, de Wilt JH
Dis Colon Rectum 2016 Feb;59(2):148-56. doi: 10.1097/DCR.0000000000000547. PMID: 26734974

Colorectal cancer in young adults.

Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403

Anal neoplasms.

Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Cancer cellulitis.

Graham BS, Wong SW
South Med J 1984 Feb;77(2):277-8. doi: 10.1097/00007611-198402000-00044. PMID: 6701607

See all (5868)

Therapy

Surgical steps for standard laparoscopic low anterior resection.

Allen SK, Schwab KE, Rockall TA
Minerva Chir 2018 Apr;73(2):227-238. Epub 2018 Feb 21 doi: 10.23736/S0026-4733.18.07572-7. PMID: 29471614

Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial.

Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751 Free PMC Article

The neoadjuvant treatment of rectal cancer: a review.

Nussbaum N, Altomare I
Curr Oncol Rep 2015 Mar;17(3):434. doi: 10.1007/s11912-014-0434-9. PMID: 25691086

Neoadjuvant and adjuvant therapy for rectal cancer.

Arnoletti JP, Bland KI
Surg Oncol Clin N Am 2006 Jan;15(1):147-57. doi: 10.1016/j.soc.2005.08.001. PMID: 16389155

See all (4696)

Prognosis

Survival and prognostic factors in patients with rectal squamous cell carcinoma.

Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124

Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial.

Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
Lancet Oncol 2017 Mar;18(3):336-346. Epub 2017 Feb 10 doi: 10.1016/S1470-2045(17)30086-4. PMID: 28190762

Anal Dysplasia.

Messick CA, Rodriguez-Bigas MA
Surg Oncol Clin N Am 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. PMID: 27889035

Colorectal cancer in young adults.

Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403

See all (6813)

Clinical prediction guides

Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.

Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557

Survival and prognostic factors in patients with rectal squamous cell carcinoma.

Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124

Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy.

Pai RK, Pai RK
Mod Pathol 2018 Jan;31(1):4-23. Epub 2017 Aug 4 doi: 10.1038/modpathol.2017.87. PMID: 28776577

Rectal cancer: An evidence-based update for primary care providers.

Gaertner WB, Kwaan MR, Madoff RD, Melton GB
World J Gastroenterol 2015 Jul 7;21(25):7659-71. doi: 10.3748/wjg.v21.i25.7659. PMID: 26167068 Free PMC Article

Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma.

Lehmann FS, Trapani F, Fueglistaler I, Terracciano LM, von Flüe M, Cathomas G, Zettl A, Benkert P, Oertli D, Beglinger C
World J Gastroenterol 2014 May 7;20(17):4994-9. doi: 10.3748/wjg.v20.i17.4994. PMID: 24803811 Free PMC Article

See all (4506)

Recent systematic reviews

Health effects of milk consumption: phenome-wide Mendelian randomization study.

Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608 Free PMC Article

Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.

Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931 Free PMC Article

Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.

Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534

Systematic review and meta-analysis of rectal washout on risk of local recurrence for cancer.

Zhou C, Ren Y, Li J, Li X, He J, Liu P
J Surg Res 2014 Jun 1;189(1):7-16. Epub 2014 Jan 24 doi: 10.1016/j.jss.2014.01.030. PMID: 24630520

Rectal carcinoids: a systematic review.

McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

See all (108)

MedGen

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Rectal Undifferentiated Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Recent activity