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Ureter Undifferentiated Carcinoma

MedGen UID:
234453
•Concept ID:
C1336866
•
Neoplastic Process
Synonyms: Anaplastic Carcinoma of the Ureter; Anaplastic Carcinoma of Ureter; Anaplastic Ureter Carcinoma; Anaplastic Ureteral Carcinoma; Undifferentiated Carcinoma of the Ureter; Undifferentiated Carcinoma of Ureter; Undifferentiated Ureter Carcinoma; Undifferentiated Ureteral Carcinoma

Definition

Undifferentiated carcinoma that affects the ureter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUreter Undifferentiated Carcinoma

Professional guidelines

PubMed

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment.
Zeng X, Yi S
Int J Gynecol Cancer 2018 Jul;28(6):1085-1089. doi: 10.1097/IGC.0000000000001269. PMID: 29727350
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Recent clinical studies

Etiology

Annular-shaped stenosis in the ureter: Caution should be taken.
Ming J, Wang Y, Su Z, Wang C
Urol Oncol 2022 Jun;40(6):274.e7-274.e14. Epub 2022 Mar 29 doi: 10.1016/j.urolonc.2022.01.015. PMID: 35365415
Robot-Assisted Radical Nephroureterectomy.
Joseph JP, O'Malley P, Su LM
J Endourol 2021 Sep;35(S2):S122-S131. doi: 10.1089/end.2020.1074. PMID: 34499556
Endocavitary treatment for upper tract urothelial carcinoma: A meta-analysis of the current literature.
Foerster B, D'Andrea D, Abufaraj M, Broenimann S, Karakiewicz PI, Rouprêt M, Gontero P, Lerner SP, Shariat SF, Soria F
Urol Oncol 2019 Jul;37(7):430-436. Epub 2019 Mar 4 doi: 10.1016/j.urolonc.2019.02.004. PMID: 30846387
Biological Behavior and Long-Term Outcomes of Carcinoma In Situ in Upper Urinary Tract Managed by Radical Nephroureterectomy.
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Laparoscopic nephroureterectomy: long-term outcomes.
Eng MK, Shalhav AL
Curr Opin Urol 2008 Mar;18(2):157-62. doi: 10.1097/MOU.0b013e3282f4a9ca. PMID: 18303536

Diagnosis

Annular-shaped stenosis in the ureter: Caution should be taken.
Ming J, Wang Y, Su Z, Wang C
Urol Oncol 2022 Jun;40(6):274.e7-274.e14. Epub 2022 Mar 29 doi: 10.1016/j.urolonc.2022.01.015. PMID: 35365415
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Biological Behavior and Long-Term Outcomes of Carcinoma In Situ in Upper Urinary Tract Managed by Radical Nephroureterectomy.
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Therapy

Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment.
Zeng X, Yi S
Int J Gynecol Cancer 2018 Jul;28(6):1085-1089. doi: 10.1097/IGC.0000000000001269. PMID: 29727350
Epidemiology of urothelial carcinoma.
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Prognosis

Annular-shaped stenosis in the ureter: Caution should be taken.
Ming J, Wang Y, Su Z, Wang C
Urol Oncol 2022 Jun;40(6):274.e7-274.e14. Epub 2022 Mar 29 doi: 10.1016/j.urolonc.2022.01.015. PMID: 35365415
Clinicopathologic features of the ureteral neuroendocrine tumors.
Wang H, Ma C, Wu J, Zhao F, Zou Y, Zhang W, Jiang Y
Pathol Res Pract 2020 Feb;216(2):152788. Epub 2019 Dec 13 doi: 10.1016/j.prp.2019.152788. PMID: 31859117
Management of distal ureter and bladder cuff at the time of nephroureterectomy: surgical techniques and predictors of outcome.
Attalla K, Patnaik S, Vellos T, Mehrazin R
Future Oncol 2019 Jul;15(20):2385-2393. Epub 2019 Jun 25 doi: 10.2217/fon-2019-0064. PMID: 31237445
Concurrent renal cell carcinoma and urothelial carcinoma: long-term follow-up study of 27 cases.
Qi N, Chen Y, Gong K, Li H
World J Surg Oncol 2018 Jan 25;16(1):16. doi: 10.1186/s12957-018-1321-x. PMID: 29370814Free PMC Article
Biological Behavior and Long-Term Outcomes of Carcinoma In Situ in Upper Urinary Tract Managed by Radical Nephroureterectomy.
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861

Clinical prediction guides

Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
Lwin AA, Hsu CH, Chipollini J
Clin Genitourin Cancer 2020 Feb;18(1):45-49.e1. Epub 2019 Nov 6 doi: 10.1016/j.clgc.2019.10.023. PMID: 31786118
Management of distal ureter and bladder cuff at the time of nephroureterectomy: surgical techniques and predictors of outcome.
Attalla K, Patnaik S, Vellos T, Mehrazin R
Future Oncol 2019 Jul;15(20):2385-2393. Epub 2019 Jun 25 doi: 10.2217/fon-2019-0064. PMID: 31237445
Endocavitary treatment for upper tract urothelial carcinoma: A meta-analysis of the current literature.
Foerster B, D'Andrea D, Abufaraj M, Broenimann S, Karakiewicz PI, Rouprêt M, Gontero P, Lerner SP, Shariat SF, Soria F
Urol Oncol 2019 Jul;37(7):430-436. Epub 2019 Mar 4 doi: 10.1016/j.urolonc.2019.02.004. PMID: 30846387
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Recent systematic reviews

Adjuvant Radiotherapy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Systematic Review of the Incidence of and Risk Factors for Urothelial Cancers and Renal Cell Carcinoma Among Patients with Haematuria.
Rai BP, Luis Dominguez Escrig J, Vale L, Kuusk T, Capoun O, Soukup V, Bruins HM, Yuan Y, Violette PD, Santesso N, van Rhijn BWG, Hugh Mostafid A, Imran Omar M
Eur Urol 2022 Aug;82(2):182-192. Epub 2022 Apr 5 doi: 10.1016/j.eururo.2022.03.027. PMID: 35393159
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

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