Phosphoribosylaminoimidazole carboxylase deficiency- MedGen UID:
- 713858
- •Concept ID:
- C1291561
- •
- Disease or Syndrome
Phosphoribosylaminoimidazole carboxylase deficiency (PAICSD) is an autosomal recessive disorder characterized by multiple congenital anomalies and early neonatal death (Pelet et al., 2019).
LADD syndrome 1- MedGen UID:
- 1824096
- •Concept ID:
- C5774323
- •
- Disease or Syndrome
Lacrimoauriculodentodigital syndrome-1 (LADD1) is a multiple congenital anomaly disorder mainly affecting lacrimal glands and ducts, salivary glands and ducts, ears, teeth, and distal limb segments (summary by Rohmann et al., 2006).
Genetic Heterogeneity of Lacrimoauriculodentodigital Syndrome
LADD syndrome-2 (LADD2; 620192) is caused by mutation in the FGFR3 gene (134934) on chromosome 4p16, and LADD syndrome-3 (LADD3; 620193) is caused by mutation in the FGF10 gene, an FGFR ligand, on chromosome 5p12.