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Salivary Gland Cystadenoma

MedGen UID:
234767
Concept ID:
C1335898
Neoplastic Process

Definition

An uncommon benign epithelial tumor, characterized by predominantly unicystic or multicystic growth; there is focal intraluminal papillary proliferation of the lining epithelium. Nearly half occur in the parotid gland. In the minor salivary glands, women are affected more than men. In the major salivary glands, cystadenomas present as slowly enlarging, asymptomatic masses that may be slightly compressible. Cystadenocarcinoma is the malignant counterpart. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Cystadenoma

Professional guidelines

PubMed

Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033
Healey WV, Perzin KH, Smith L
Cancer 1970 Aug;26(2):368-88. doi: 10.1002/1097-0142(197008)26:2<368::aid-cncr2820260219>3.0.co;2-k. PMID: 5451215
ABBISS JW, PIERSON JC
Del State Med J 1954 Oct;26(10):257-60. PMID: 13210035

Recent clinical studies

Etiology

Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678Free PMC Article
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN
Head Neck Pathol 2020 Dec;14(4):1013-1020. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01190-8. PMID: 32506376Free PMC Article
Israel Y, Rachmiel A, Ziv G, Nagler R
Anticancer Res 2016 Aug;36(8):4151-4. PMID: 27466524
Faur A, Lazăr E, Cornianu M, Dema A, Vidita CG, Găluşcan A
Rom J Morphol Embryol 2009;50(2):269-73. PMID: 19434322

Diagnosis

Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Israel Y, Rachmiel A, Ziv G, Nagler R
Anticancer Res 2016 Aug;36(8):4151-4. PMID: 27466524
Kuo YJ, Weinreb I, Perez-Ordonez B
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S59-67. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0460-1. PMID: 23821212Free PMC Article
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Mantsopoulos K, Koch M, Goncalves M, Iro H
Oral Oncol 2018 Jul;82:176-180. Epub 2018 Jun 1 doi: 10.1016/j.oraloncology.2018.05.022. PMID: 29909894
Halbritter SA, Altermatt HJ, Caversaccio M, Bornstein MM
Quintessence Int 2009 Feb;40(2):167-9. PMID: 19169449
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566
Martins C, Fonseca I, Félix A, Roque L, Soares J
J Surg Oncol 1995 Dec;60(4):232-7. doi: 10.1002/jso.2930600404. PMID: 8551731
Yoshimura Y, Tawara K, Yoshigi J, Nagaoka S
J Oral Maxillofac Surg 1995 Apr;53(4):448-53. doi: 10.1016/0278-2391(95)90722-x. PMID: 7699501

Prognosis

Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN
Head Neck Pathol 2020 Dec;14(4):1013-1020. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01190-8. PMID: 32506376Free PMC Article
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Clinical prediction guides

Malik V, Dixit M, Sharma S, Jain A, Dhankad A, Mohanty SK
Pathol Res Pract 2023 Nov;251:154884. Epub 2023 Oct 11 doi: 10.1016/j.prp.2023.154884. PMID: 37913638
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Morley DJ, Hodes JE, Calland J, Hodes ME
Hum Pathol 1983 Nov;14(11):969-73. doi: 10.1016/s0046-8177(83)80176-2. PMID: 6195082

Recent systematic reviews

Stewart KE, Bannon R, Bannister M
Ann R Coll Surg Engl 2021 Jan;103(1):47-52. Epub 2020 Sep 24 doi: 10.1308/rcsann.2020.0194. PMID: 32969265Free PMC Article

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