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Salivary gland epithelial myoepithelial carcinoma

MedGen UID:
234769
•Concept ID:
C1335900
•
Neoplastic Process
Synonyms: Salivary Gland Epithelial Myoepithelial Carcinoma; salivary gland epithelial myoepithelial carcinoma; Salivary Gland Epithelial-Myoepithelial Carcinoma
 
Monarch Initiative: MONDO:0020694

Definition

A carcinoma that arises from the salivary glands, most often the parotid gland. It presents as a slow growing and painless mass. It is characterized by the presence of duct-like structures lined by two layers of cells, an inner layer composed of epithelial-type cells and an outer layer composed of clear, myoepithelial-type cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland epithelial myoepithelial carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Epithelial-myoepithelial carcinoma of the maxillofacial and sinonasal region: a systematic review of presenting characteristics, treatment modalities, and associated outcomes.
Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947
The Decline of Salivary Adenocarcinoma Not Otherwise Specified as a Tumor Entity: Reclassification Using Contemporary Immunohistochemical Profiling and Diagnostic Criteria.
Rooper LM, Mansour M, Yonescu R, Oliai BR, Bishop JA, Westra WH
Am J Surg Pathol 2021 Jun 1;45(6):753-764. doi: 10.1097/PAS.0000000000001636. PMID: 33284193

Recent clinical studies

Etiology

Clinical and pathological analysis of 10 cases of salivary gland epithelial-myoepithelial carcinoma.
Wang F, Li B, Wang Y, Shen Y, Yang H
Medicine (Baltimore) 2020 Oct 9;99(41):e22671. doi: 10.1097/MD.0000000000022671. PMID: 33031333Free PMC Article
Adenomyoepitheliomas of the Breast Frequently Harbor Recurrent Hotspot Mutations in PIK3-AKT Pathway-related Genes and a Subset Show Genetic Similarity to Salivary Gland Epithelial-Myoepithelial Carcinoma.
Lubin D, Toorens E, Zhang PJ, Jaffer S, Baraban E, Bleiweiss IJ, Nayak A
Am J Surg Pathol 2019 Jul;43(7):1005-1013. doi: 10.1097/PAS.0000000000001275. PMID: 31094929
Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate.
Teppo H, Paronen I
J Craniofac Surg 2008 Nov;19(6):1689-91. doi: 10.1097/SCS.0b013e318189723a. PMID: 19098583

Diagnosis

Clinical and pathological analysis of 10 cases of salivary gland epithelial-myoepithelial carcinoma.
Wang F, Li B, Wang Y, Shen Y, Yang H
Medicine (Baltimore) 2020 Oct 9;99(41):e22671. doi: 10.1097/MD.0000000000022671. PMID: 33031333Free PMC Article
Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate.
Teppo H, Paronen I
J Craniofac Surg 2008 Nov;19(6):1689-91. doi: 10.1097/SCS.0b013e318189723a. PMID: 19098583
Salivary Gland Epithelial- Myoepithelial Carcinoma: behaviour, diagnosis and treatment.
Senis-Segarra L, Sahuquillo-Arce E, Davo R, Hamad-Arcis P, Floria-Garcia LM, Baquero MC
Med Oral 2002 Nov-Dec;7(5):391-5. PMID: 12415223

Prognosis

Clinical and pathological analysis of 10 cases of salivary gland epithelial-myoepithelial carcinoma.
Wang F, Li B, Wang Y, Shen Y, Yang H
Medicine (Baltimore) 2020 Oct 9;99(41):e22671. doi: 10.1097/MD.0000000000022671. PMID: 33031333Free PMC Article
Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate.
Teppo H, Paronen I
J Craniofac Surg 2008 Nov;19(6):1689-91. doi: 10.1097/SCS.0b013e318189723a. PMID: 19098583

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