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Gastrointestinal stromal tumor of small intestine

MedGen UID:
234790
•Concept ID:
C1335996
•
Neoplastic Process
Synonym: Small Intestinal Gastrointestinal Stromal Tumor
SNOMED CT: Gastrointestinal stromal tumor of small intestine (445737002)

Definition

A gastrointestinal stromal tumor that arises from the small intestine. It usually affects adults over fifty years of age. The majority of cases have spindle cell morphology. The prognosis depends on the tumor size and the mitotic activity. [from NCI]

Professional guidelines

PubMed

Management of Advanced Small Bowel Cancer.
Puccini A, Battaglin F, Lenz HJ
Curr Treat Options Oncol 2018 Nov 5;19(12):69. doi: 10.1007/s11864-018-0592-3. PMID: 30397729Free PMC Article
Small bowel tumors: pathology and management.
Williamson JM, Williamson RC
J Med Assoc Thai 2014 Jan;97(1):126-37. PMID: 24701741
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastrointestinal Stromal Tumors, 2023

Recent clinical studies

Etiology

Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Minimally Invasive Small Bowel Cancer Surgery.
Baiu I, Visser BC
Surg Oncol Clin N Am 2019 Apr;28(2):273-283. Epub 2018 Dec 24 doi: 10.1016/j.soc.2018.11.008. PMID: 30851828
Bowel Imaging in Children: Part 2.
Kandasamy D, Sharma R, Gupta AK
Indian J Pediatr 2019 Sep;86(9):817-829. Epub 2019 Feb 21 doi: 10.1007/s12098-019-02878-8. PMID: 30790185
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Diagnosis

Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Small intestine gastrointestinal stromal tumors.
Grover S, Ashley SW, Raut CP
Curr Opin Gastroenterol 2012 Mar;28(2):113-23. doi: 10.1097/MOG.0b013e32834ec154. PMID: 22157511
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Therapy

Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial.
Subbiah V, Kreitman RJ, Wainberg ZA, Gazzah A, Lassen U, Stein A, Wen PY, Dietrich S, de Jonge MJA, Blay JY, Italiano A, Yonemori K, Cho DC, de Vos FYFL, Moreau P, Fernandez EE, Schellens JHM, Zielinski CC, Redhu S, Boran A, Passos VQ, Ilankumaran P, Bang YJ
Nat Med 2023 May;29(5):1103-1112. Epub 2023 Apr 14 doi: 10.1038/s41591-023-02321-8. PMID: 37059834Free PMC Article
KIT gene mutations in gastrointestinal stromal tumor.
Kang W, Zhu C, Yu J, Ye X, Ma Z
Front Biosci (Landmark Ed) 2015 Jun 1;20(6):919-26. doi: 10.2741/4346. PMID: 25961532
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Small intestine gastrointestinal stromal tumors.
Grover S, Ashley SW, Raut CP
Curr Opin Gastroenterol 2012 Mar;28(2):113-23. doi: 10.1097/MOG.0b013e32834ec154. PMID: 22157511
Combined surgical and molecular therapy: the gastrointestinal stromal tumor model.
Gold JS, Dematteo RP
Ann Surg 2006 Aug;244(2):176-84. doi: 10.1097/01.sla.0000218080.94145.cf. PMID: 16858179Free PMC Article

Prognosis

Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Small intestine gastrointestinal stromal tumors.
Grover S, Ashley SW, Raut CP
Curr Opin Gastroenterol 2012 Mar;28(2):113-23. doi: 10.1097/MOG.0b013e32834ec154. PMID: 22157511
Histopathology of gastrointestinal stromal tumor.
Miettinen M, Lasota J
J Surg Oncol 2011 Dec;104(8):865-73. doi: 10.1002/jso.21945. PMID: 22069171Free PMC Article
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Clinical prediction guides

Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
Diagnosis and Treatment of Duodenal Gastrointestinal Stromal Tumors.
Du H, Ning L, Li S, Lou X, Chen H, Hu F, Shan G, Zhang F, Xu G
Clin Transl Gastroenterol 2020 Mar;11(3):e00156. doi: 10.14309/ctg.0000000000000156. PMID: 32352716Free PMC Article
KIT gene mutations in gastrointestinal stromal tumor.
Kang W, Zhu C, Yu J, Ye X, Ma Z
Front Biosci (Landmark Ed) 2015 Jun 1;20(6):919-26. doi: 10.2741/4346. PMID: 25961532
Small intestine gastrointestinal stromal tumors.
Grover S, Ashley SW, Raut CP
Curr Opin Gastroenterol 2012 Mar;28(2):113-23. doi: 10.1097/MOG.0b013e32834ec154. PMID: 22157511
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Recent systematic reviews

Current treatment and outcomes of pediatric gastrointestinal stromal tumors (GIST): a systematic review of published studies.
Raitio A, Salim A, Mullassery D, Losty PD
Pediatr Surg Int 2021 Sep;37(9):1161-1165. Epub 2021 Jun 3 doi: 10.1007/s00383-021-04931-0. PMID: 34081161Free PMC Article
Gastrointestinal Stromal Tumours (GIST): A Review of Cases from Nigeria.
Ogun GO, Adegoke OO, Rahman A, Egbo OH
J Gastrointest Cancer 2020 Sep;51(3):729-737. doi: 10.1007/s12029-019-00318-6. PMID: 31659675
Pancreaticoduodenectomy versus limited resection for duodenal gastrointestinal stromal tumors: a systematic review and meta-analysis.
Shen Z, Chen P, Du N, Khadaroo PA, Mao D, Gu L
BMC Surg 2019 Aug 28;19(1):121. doi: 10.1186/s12893-019-0587-4. PMID: 31455328Free PMC Article
Stromal tumor of the ampulla of vater: report of a case and systematic review of reported cases.
Jerraya H, Bel Haj Salah R, Ben Mena K, Haouet K, Zaouche A
Tunis Med 2009 Sep;87(9):556-9. PMID: 20180372

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastrointestinal Stromal Tumors, 2023

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