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Soft Tissue Fibrosarcoma

MedGen UID:
234796
•Concept ID:
C1336021
•
Neoplastic Process
Synonyms: Fibrosarcoma of Soft Tissue; Fibrosarcoma of the Soft Tissue

Definition

A usually aggressive malignant neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern. [from NCI]

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Treatment Concepts and Challenges in Nonrhabdomyosarcoma Soft Tissue Sarcomas.
Fuchs J, Schmidt A, Warmann SW, Rodeberg DA
Surg Oncol Clin N Am 2021 Apr;30(2):355-371. Epub 2021 Jan 27 doi: 10.1016/j.soc.2020.11.004. PMID: 33706905
Advances in the Diagnosis and Management of Neonatal Sarcomas.
Rashid T, Noyd DH, Iranzad N, Davis JT, Deel MD
Clin Perinatol 2021 Mar;48(1):117-145. doi: 10.1016/j.clp.2020.11.007. PMID: 33583500

Recent clinical studies

Etiology

Contrast-enhanced right atrial mass: tumour or thrombus?
Calleja AC, Alharthi MS, Khandheria BK, Chaliki HP
Eur J Echocardiogr 2009 Mar;10(2):365-6. Epub 2008 Dec 9 doi: 10.1093/ejechocard/jen310. PMID: 19066263
Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.
Scott SM, Reiman HM, Pritchard DJ, Ilstrup DM
Cancer 1989 Aug 15;64(4):925-31. doi: 10.1002/1097-0142(19890815)64:4<925::aid-cncr2820640427>3.0.co;2-t. PMID: 2545330
Recurrent soft-tissue fibrosarcoma with a long clinical course.
Manneh NA, Urca I
Isr J Med Sci 1971 Oct;7(10):1160-3. PMID: 5143182

Diagnosis

S100 and Pan-Trk Staining to Report NTRK Fusion-Positive Uterine Sarcoma: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting.
Chiang S
Int J Gynecol Pathol 2021 Jan;40(1):24-27. doi: 10.1097/PGP.0000000000000702. PMID: 33290352
Intraoral Soft Tissue Fibrosarcoma in a Four-Year-Old Child: An Unusual Case Report.
Singh A, Singh H, Kumar D, Singh A, Biswal BN
J Clin Pediatr Dent 2019;43(6):408-412. doi: 10.17796/1053-4625-43.6.8. PMID: 31657985
Contrast-enhanced right atrial mass: tumour or thrombus?
Calleja AC, Alharthi MS, Khandheria BK, Chaliki HP
Eur J Echocardiogr 2009 Mar;10(2):365-6. Epub 2008 Dec 9 doi: 10.1093/ejechocard/jen310. PMID: 19066263
Sclerosing epithelioid fibrosarcoma of the pituitary.
Massier A, Scheithauer BW, Taylor HC, Clark C, Llerena L
Endocr Pathol 2007 Winter;18(4):233-8. doi: 10.1007/s12022-007-9010-2. PMID: 18097772
Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.
Scott SM, Reiman HM, Pritchard DJ, Ilstrup DM
Cancer 1989 Aug 15;64(4):925-31. doi: 10.1002/1097-0142(19890815)64:4<925::aid-cncr2820640427>3.0.co;2-t. PMID: 2545330

Therapy

Contrast-enhanced right atrial mass: tumour or thrombus?
Calleja AC, Alharthi MS, Khandheria BK, Chaliki HP
Eur J Echocardiogr 2009 Mar;10(2):365-6. Epub 2008 Dec 9 doi: 10.1093/ejechocard/jen310. PMID: 19066263
Sclerosing epithelioid fibrosarcoma of the pituitary.
Massier A, Scheithauer BW, Taylor HC, Clark C, Llerena L
Endocr Pathol 2007 Winter;18(4):233-8. doi: 10.1007/s12022-007-9010-2. PMID: 18097772

Prognosis

Large left ventricular metastasis causing left ventricular outflow tract obstruction and haemolysis.
Coller JM, Parente P, Esmore D, New G, Murugasu A, Cooke JC
Eur J Echocardiogr 2009 May;10(3):456-8. Epub 2009 Jan 27 doi: 10.1093/ejechocard/jen340. PMID: 19174445
Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.
Scott SM, Reiman HM, Pritchard DJ, Ilstrup DM
Cancer 1989 Aug 15;64(4):925-31. doi: 10.1002/1097-0142(19890815)64:4<925::aid-cncr2820640427>3.0.co;2-t. PMID: 2545330
Radiation-induced soft-tissue fibrosarcoma: surgical therapy and salvage.
O'Neil MB Jr, Cocke W, Mason D, Hurley EJ
Ann Thorac Surg 1982 Jun;33(6):624-8. doi: 10.1016/s0003-4975(10)60824-7. PMID: 6284077
Recurrent soft-tissue fibrosarcoma with a long clinical course.
Manneh NA, Urca I
Isr J Med Sci 1971 Oct;7(10):1160-3. PMID: 5143182

Clinical prediction guides

Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.
Scott SM, Reiman HM, Pritchard DJ, Ilstrup DM
Cancer 1989 Aug 15;64(4):925-31. doi: 10.1002/1097-0142(19890815)64:4<925::aid-cncr2820640427>3.0.co;2-t. PMID: 2545330

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