U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spindle cell neoplasm

MedGen UID:
234806
•Concept ID:
C1336052
•
Neoplastic Process
Synonyms: Spindle Cell Neoplasm; spindle cell neoplasm; Spindle Cell Tumor; spindle cell tumor
 
Monarch Initiative: MONDO:0020664

Definition

A benign or malignant neoplasm characterized by the presence of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell neoplasm

Professional guidelines

PubMed

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Myxofibrosarcoma: cytomorphologic findings and differential diagnosis on fine needle aspiration.
Olson MT, Ali SZ
Acta Cytol 2012;56(1):15-24. Epub 2012 Jan 4 doi: 10.1159/000333134. PMID: 22236741
Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract.
Turner MS, Goldsmith JD
Arch Pathol Lab Med 2009 Sep;133(9):1370-4. doi: 10.5858/133.9.1370. PMID: 19722741

Recent clinical studies

Etiology

NTRK-rearranged spindle cell neoplasms: a clinicopathological and molecular study of 13 cases with peculiar characteristics at one of the largest institutions in China.
Yin L, Shi C, He X, Qiu Y, Chen H, Chen M, Zhang Z, Chen Y, Zhou Y, Zhang H
Pathology 2023 Apr;55(3):362-374. Epub 2022 Dec 21 doi: 10.1016/j.pathol.2022.10.003. PMID: 36641377
Intestinal LMNA::NTRK1-fused spindle cell neoplasm with S100 and CD34 coexpression: a new case.
Rahim S, Alkhaldi SS, Alasousi K, Ali RH
BMJ Case Rep 2022 Nov 10;15(11) doi: 10.1136/bcr-2022-251270. PMID: 36357104Free PMC Article
Infantile Fibrosarcoma and Other Spindle Cell Neoplasms of Infancy. A Review of Morphologically Overlapping yet Molecularly Distinctive Entities.
Jabbari S, Salari B, He M, Dehner LP
Fetal Pediatr Pathol 2022 Dec;41(6):996-1014. Epub 2022 Jan 19 doi: 10.1080/15513815.2021.2024631. PMID: 35044292
ALK rearrangements in infantile fibrosarcoma-like spindle cell tumours of soft tissue and kidney.
Tan SY, Al-Ibraheemi A, Ahrens WA, Oesterheld JE, Fanburg-Smith JC, Liu YJ, Spunt SL, Rudzinski ER, Coffin C, Davis JL
Histopathology 2022 Mar;80(4):698-707. Epub 2022 Jan 2 doi: 10.1111/his.14603. PMID: 34843129
Testicular Myofibroma in Children: A Case Report and Review of the Literature.
Koh SS, Kim SJ, Seghers VJ, Patel KR, Koh CJ, Lee DG
Urology 2021 Oct;156:e150-e153. Epub 2021 Mar 23 doi: 10.1016/j.urology.2021.03.006. PMID: 33766714

Diagnosis

Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Fischer GM, Papke DJ Jr
Semin Diagn Pathol 2023 Jul;40(4):246-257. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.014. PMID: 37156707
Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Update on Cutaneous Soft Tissue Tumors.
Dermawan JK, Ko JS, Billings SD
Surg Pathol Clin 2021 Jun;14(2):195-207. doi: 10.1016/j.path.2021.03.002. PMID: 34023100
A basic immunohistochemical panel for the diagnosis of soft tissue tumors.
Michal M
Cesk Patol 2021 Spring;57(1):12-18. PMID: 33910344
Follicular Dendritic Cell Sarcoma.
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378

Therapy

Cutaneous solitary fibrous tumor: Report of three cases with review of histopathological mimics.
Vincek V, Kallis P, Vause A, Vincek E, Ilkovitch D, Motaparthi K
J Cutan Pathol 2022 Feb;49(2):167-171. Epub 2021 Oct 17 doi: 10.1111/cup.14138. PMID: 34569103
A Case of Inv(1)(q23q31) TPR-NTRK1 Fusion-Positive Spindle Cell Neoplasm in an Infant-Uncovered by Next-Generation Sequencing: Diagnostic Challenge, Review, and Therapeutic Implications.
Rekhi B, Shetty O, Bapat P, Gurav M, Qureshi S
Int J Surg Pathol 2021 Feb;29(1):102-108. Epub 2020 Jun 3 doi: 10.1177/1066896920927467. PMID: 32489127
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein.
Subbiah V, Westin SN, Wang K, Araujo D, Wang WL, Miller VA, Ross JS, Stephens PJ, Palmer GA, Ali SM
J Hematol Oncol 2014 Jan 14;7:8. doi: 10.1186/1756-8722-7-8. PMID: 24422672Free PMC Article
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin.
Sigal AC, Keenan M, Lazova R
Am J Dermatopathol 2012 Apr;34(2):145-50. doi: 10.1097/DAD.0b013e318225b596. PMID: 22207443

Prognosis

Follicular Dendritic Cell Sarcoma.
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature.
Gavino AC, Spears MD, Peng Y
Int J Surg Pathol 2010 Oct;18(5):394-7. Epub 2008 Nov 17 doi: 10.1177/1066896908327166. PMID: 19017660
Cutaneous Rosai-Dorfman disease.
Rubenstein MA, Farnsworth NN, Pielop JA, Orengo IF, Curry JL, Drucker CR, Hsu S
Dermatol Online J 2006 Jan 27;12(1):8. PMID: 16638376
A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma.
Spencer L, Jukic D
Dermatol Online J 2004 Jul 15;10(1):8. PMID: 15347490

Clinical prediction guides

Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT): A report of three FNA cases and comparison with spindle cell/pleomorphic lipoma cytopathology.
Wakely PE Jr
Cytopathology 2023 Jul;34(4):346-352. Epub 2023 Mar 17 doi: 10.1111/cyt.13227. PMID: 36856555
Clinicopathological and genomic characterization of BCORL1-driven high-grade endometrial stromal sarcomas.
Lin DI, Huang RSP, Mata DA, Decker B, Danziger N, Lechpammer M, Hiemenz M, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 Dec;34(12):2200-2210. Epub 2021 Jul 23 doi: 10.1038/s41379-021-00873-z. PMID: 34302054
A rare case of malignant solitary fibrous tumor in prostate with review of the literature.
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
Diagn Pathol 2017 Jul 7;12(1):50. doi: 10.1186/s13000-017-0640-5. PMID: 28687087Free PMC Article
Syndrome in question.
Rosmaninho A, Carvalho S, Oujo E, Horta M
An Bras Dermatol 2016 Apr;91(2):245-7. doi: 10.1590/abd1806-4841.20164231. PMID: 27192531Free PMC Article
A solitary fibrous tumor of the kidney in a 26-year-old man.
Constantinidis C, Koutalellis G, Liapis G, Stravodimos C, Alexandrou P, Adamakis I
Can J Urol 2007 Jun;14(3):3583-7. PMID: 17594751

Recent systematic reviews

Clinicopathological and Molecular Characteristics of Intraosseous Rhabdomyosarcoma Involving Head and Neck Region: A Systematic Review and Meta-Analysis.
Sivakumar N, Sharma P, Chandra S, Gupta S, Samadi FM, Baghel S
Pediatr Dev Pathol 2023 May-Jun;26(3):299-309. Epub 2023 Apr 21 doi: 10.1177/10935266231165636. PMID: 37082926
Synovial sarcoma of the stomach: case report and systematic review of the literature.
Kurpińska M, Kaznowska E, Kruczak A, Mularz K, Adamczyk A, Długosz J, Gancarz J, Ryś J
Pol J Pathol 2020;71(2):181-193. doi: 10.5114/pjp.2020.97024. PMID: 32729309
Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature.
Prablek M, Srinivasan VM, Srivatsan A, Holdener S, Oneissi M, Heck KA, Jalali A, Mandel J, Viswanathan A, Patel AJ
BMC Cancer 2019 Nov 15;19(1):1119. doi: 10.1186/s12885-019-6316-7. PMID: 31730471Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...