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Spindle cell neoplasm

MedGen UID:
234806
•Concept ID:
C1336052
•
Neoplastic Process
Synonyms: Spindle Cell Neoplasm; spindle cell neoplasm; Spindle Cell Tumor; spindle cell tumor; spindle cell tumour
 
Monarch Initiative: MONDO:0020664

Definition

A benign or malignant neoplasm characterized by the presence of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell neoplasm

Professional guidelines

PubMed

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis.
Bishop JA, Rekhtman N, Chun J, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2010 Apr 25;118(2):83-9. doi: 10.1002/cncy.20069. PMID: 20209623
Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract.
Turner MS, Goldsmith JD
Arch Pathol Lab Med 2009 Sep;133(9):1370-4. doi: 10.5858/133.9.1370. PMID: 19722741

Recent clinical studies

Etiology

NTRK-rearranged spindle cell neoplasm: Initial observation of imaging appearance and clinicopathologic correlation.
Spano M, Davis-Hayes C, Hameed M, Benayed R, Hwang S
Clin Imaging 2024 Jun;110:110134. Epub 2024 Mar 22 doi: 10.1016/j.clinimag.2024.110134. PMID: 38631176
NTRK-rearranged spindle cell neoplasms: a clinicopathological and molecular study of 13 cases with peculiar characteristics at one of the largest institutions in China.
Yin L, Shi C, He X, Qiu Y, Chen H, Chen M, Zhang Z, Chen Y, Zhou Y, Zhang H
Pathology 2023 Apr;55(3):362-374. Epub 2022 Dec 21 doi: 10.1016/j.pathol.2022.10.003. PMID: 36641377
Intestinal LMNA::NTRK1-fused spindle cell neoplasm with S100 and CD34 coexpression: a new case.
Rahim S, Alkhaldi SS, Alasousi K, Ali RH
BMJ Case Rep 2022 Nov 10;15(11) doi: 10.1136/bcr-2022-251270. PMID: 36357104Free PMC Article
ALK rearrangements in infantile fibrosarcoma-like spindle cell tumours of soft tissue and kidney.
Tan SY, Al-Ibraheemi A, Ahrens WA, Oesterheld JE, Fanburg-Smith JC, Liu YJ, Spunt SL, Rudzinski ER, Coffin C, Davis JL
Histopathology 2022 Mar;80(4):698-707. Epub 2022 Jan 2 doi: 10.1111/his.14603. PMID: 34843129
S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion.
Paton DJW, Wong D, Amanuel B, Cheah K, Ardakani NM
Am J Dermatopathol 2021 Mar 1;43(3):217-220. doi: 10.1097/DAD.0000000000001796. PMID: 33464748

Diagnosis

Primary NTRK -rearranged Spindle Cell Neoplasm of the Gastrointestinal Tract: A Clinicopathological and Molecular Analysis of 8 Cases.
Gao X, Xu S, Zhu P, Lao IW, Yu L, Wang J
Am J Surg Pathol 2024 May 1;48(5):623-631. Epub 2024 Mar 25 doi: 10.1097/PAS.0000000000002202. PMID: 38525823
PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications.
Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Fischer GM, Papke DJ Jr
Semin Diagn Pathol 2023 Jul;40(4):246-257. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.014. PMID: 37156707
Update on Cutaneous Soft Tissue Tumors.
Dermawan JK, Ko JS, Billings SD
Surg Pathol Clin 2021 Jun;14(2):195-207. doi: 10.1016/j.path.2021.03.002. PMID: 34023100
Follicular Dendritic Cell Sarcoma.
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378

Therapy

Cutaneous solitary fibrous tumor: Report of three cases with review of histopathological mimics.
Vincek V, Kallis P, Vause A, Vincek E, Ilkovitch D, Motaparthi K
J Cutan Pathol 2022 Feb;49(2):167-171. Epub 2021 Oct 17 doi: 10.1111/cup.14138. PMID: 34569103
A Case of Inv(1)(q23q31) TPR-NTRK1 Fusion-Positive Spindle Cell Neoplasm in an Infant-Uncovered by Next-Generation Sequencing: Diagnostic Challenge, Review, and Therapeutic Implications.
Rekhi B, Shetty O, Bapat P, Gurav M, Qureshi S
Int J Surg Pathol 2021 Feb;29(1):102-108. Epub 2020 Jun 3 doi: 10.1177/1066896920927467. PMID: 32489127
Vascular interventions in head and neck cancer patients as a marker of poor survival.
Krol E, Brandt CT, Blakeslee-Carter J, Ahanchi SS, Dexter DJ, Karakla D, Panneton JM
J Vasc Surg 2019 Jan;69(1):181-189. doi: 10.1016/j.jvs.2018.04.058. PMID: 30579444
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin.
Sigal AC, Keenan M, Lazova R
Am J Dermatopathol 2012 Apr;34(2):145-50. doi: 10.1097/DAD.0b013e318225b596. PMID: 22207443

Prognosis

NTRK-rearranged spindle cell neoplasm: Initial observation of imaging appearance and clinicopathologic correlation.
Spano M, Davis-Hayes C, Hameed M, Benayed R, Hwang S
Clin Imaging 2024 Jun;110:110134. Epub 2024 Mar 22 doi: 10.1016/j.clinimag.2024.110134. PMID: 38631176
An unusual case of extra-nodal interdigitating dendritic cell neoplasm: sarcoma or not?
Mainardi F, Lombardi M, Covello R, Saponaro A, Costarelli L, Giordano M, Monardo F
Acta Chir Belg 2023 Dec;123(6):687-690. Epub 2022 Jul 20 doi: 10.1080/00015458.2022.2102358. PMID: 35833666
Follicular Dendritic Cell Sarcoma.
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378
Submucosal neoplasms of the laryngeal introitus.
Friedman AD, Burns JA, Lutch MJ, Zeitels SM
J Laryngol Otol 2012 Jul;126(7):706-13. Epub 2012 May 25 doi: 10.1017/S0022215112000928. PMID: 22624973
Cutaneous Rosai-Dorfman disease.
Rubenstein MA, Farnsworth NN, Pielop JA, Orengo IF, Curry JL, Drucker CR, Hsu S
Dermatol Online J 2006 Jan 27;12(1):8. PMID: 16638376

Clinical prediction guides

NTRK-rearranged spindle cell neoplasm: Initial observation of imaging appearance and clinicopathologic correlation.
Spano M, Davis-Hayes C, Hameed M, Benayed R, Hwang S
Clin Imaging 2024 Jun;110:110134. Epub 2024 Mar 22 doi: 10.1016/j.clinimag.2024.110134. PMID: 38631176
Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT): A report of three FNA cases and comparison with spindle cell/pleomorphic lipoma cytopathology.
Wakely PE Jr
Cytopathology 2023 Jul;34(4):346-352. Epub 2023 Mar 17 doi: 10.1111/cyt.13227. PMID: 36856555
NTRK-Rearranged soft tissue neoplasms: A review of evolving diagnostic entities and algorithmic detection methods.
Surrey LF, Davis JL
Cancer Genet 2022 Jan;260-261:6-13. Epub 2021 Nov 3 doi: 10.1016/j.cancergen.2021.10.007. PMID: 34794069
Clinicopathological and genomic characterization of BCORL1-driven high-grade endometrial stromal sarcomas.
Lin DI, Huang RSP, Mata DA, Decker B, Danziger N, Lechpammer M, Hiemenz M, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 Dec;34(12):2200-2210. Epub 2021 Jul 23 doi: 10.1038/s41379-021-00873-z. PMID: 34302054
Syndrome in question.
Rosmaninho A, Carvalho S, Oujo E, Horta M
An Bras Dermatol 2016 Apr;91(2):245-7. doi: 10.1590/abd1806-4841.20164231. PMID: 27192531Free PMC Article

Recent systematic reviews

Gnathic Schwannomas: A Report of Two Cases and Systematic Review of the Literature.
Peraza Labrador AJ, Valdez LHM, Marin NRG, Ibazetta KAR, Villacis M, Chacon JL, Huaman HO, Pariahuamán HC, Angulo HB, Woo V
Head Neck Pathol 2023 Dec;17(4):984-999. Epub 2023 Dec 6 doi: 10.1007/s12105-023-01595-1. PMID: 38055108Free PMC Article
Clinicopathological and Molecular Characteristics of Intraosseous Rhabdomyosarcoma Involving Head and Neck Region: A Systematic Review and Meta-Analysis.
Sivakumar N, Sharma P, Chandra S, Gupta S, Samadi FM, Baghel S
Pediatr Dev Pathol 2023 May-Jun;26(3):299-309. Epub 2023 Apr 21 doi: 10.1177/10935266231165636. PMID: 37082926
Synovial sarcoma of the stomach: case report and systematic review of the literature.
Kurpińska M, Kaznowska E, Kruczak A, Mularz K, Adamczyk A, Długosz J, Gancarz J, Ryś J
Pol J Pathol 2020;71(2):181-193. doi: 10.5114/pjp.2020.97024. PMID: 32729309
Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature.
Prablek M, Srinivasan VM, Srivatsan A, Holdener S, Oneissi M, Heck KA, Jalali A, Mandel J, Viswanathan A, Patel AJ
BMC Cancer 2019 Nov 15;19(1):1119. doi: 10.1186/s12885-019-6316-7. PMID: 31730471Free PMC Article

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